Articles tagged "Rejection"

2022 American Transplant Congress
Time-Dependent Blood Eosinophilia Count Increases the Risk of Kidney Allograft Rejection
L. Colas¹, L. Bui², C. Kerleau³, M. Lemdani⁴, K. Autain-Renaudin⁵, A. Magnan⁶, M. Giral³, S. Brouard¹
¹CRT2I, Université de Nantes, Nantes, France, ²Service de Néphrologie, Centre Hospitalier de Mouscron, Mouscron, Belgium, ³Service de Néphrologie et Immunologie Clinique, CHU de Nantes, Nantes, France, ⁴Département de Biomathématiques, Université de Lilles, Lilles, France, ⁵Service d'Anatomie et Cytologie Pathologique, CHU de Nantes, Nantes, France, ⁶INRAe UMR 0892, Université de Versailles Saint-Quentin Paris-Saclay, Paris, France
*Purpose: There is growing evidence that type 2 immune effectors (immunoglobulin E, eosinophils, mast cells/basophils) play a role in autoimmune disorders and solid organ transplantation.…
2022 American Transplant Congress
Single Kidney Transplantation Using Pediatric Donor Kidneys: Satisfactory Outcomes but Specific Attentions Needed
M. Huang, W. Wu, X. Su, J. Li, C. Wu, H. Zhang, Q. Fu, J. Li, S. Wu, Y. Chen, Q. Zhang, L. Liu, C. Wang
The First Affiliated Hospital Of Sun Yat-sen University, Guangzhou, China
*Purpose: Utilization of pediatric donor in single kidney transplantation (SKT) are popular and can greatly expand the scarce donor pool, whereas potential risk factors remain…
2022 American Transplant Congress
RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection
Y. Shah, E. Varma, S. Rahim, C. Li, C. Snopkowski, C. Hughes, D. M. Dadhania, S. Salvatore, S. V. Seshan, O. Elemento, M. Suthanthiran, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…
2022 American Transplant Congress
Unravelling the Stage-Shift of Acute Rejection by Urine QSant
W. Yazar¹, N. Titzler¹, R. Sarwal¹, M. Sarwal², S. Ghosh¹
¹Nephrosant, Brisbane, CA, ²NephroSant, Brisbane, CA
*Purpose: Suboptimal performance in current methods for allograft monitoring underscores the unmet need for enhanced immunosurveillance accuracy, to uncover the alloimmunity flux. QSant[Yang et al,…
2022 American Transplant Congress
Real-Time Biometric Monitoring Using Wearable Devices for Pediatric Heart Transplant Rejection and Infection Surveillance
D. Gandla¹, J. B. Edelson², E. Mukhtar¹, J. Callanan¹, H. Lad¹, H. Gao¹, J. Cornetta¹, B. Keating¹
¹Department of Surgery, Perelman School of Medicine, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Monitoring for acute rejection (AR) after orthotopic heart transplantation (OHTx) is primarily achieved by evaluating histological endomyocardial biopsies (EMBx). However, this procedure is limited…
2022 American Transplant Congress
Impact of the High Baseline Anti-a/b Antibody Titer on the Clinical Outcomes in ABO-incompatible Living Donor Liver Transplantation
J. Cho, B. Lee, H. Lee
Surgery, Seoul National Bundang Hospital, Seongnam, Korea, Republic of
*Purpose: Recently, advances in desensitization protocol have made ABO-incompatible (ABOi) living donor liver transplantation (LDLT) feasible option in the era of organ shortage. Although, multiple…
2022 American Transplant Congress
M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod
M. Zheng¹, W. Zijie², Z. Gui³, R. Tan¹, M. Gu³
¹Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…
2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
J. Tang¹, A. Vo¹, E. Huang¹, X. Zhang², N. Ammerman¹, A. Peng¹, R. Najjar¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…
2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
X. Lai¹, J. Wang¹, S. Han¹, C. Chunlei¹, L. VanOsdol¹, L. Gallon², J. Leventhal², M. Kandpal¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
2022 American Transplant Congress
Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation
S. Han¹, X. Lai², J. Wang¹, L. VanOsdol³, C. Chen¹, J. Mathew¹, J. R. Leventhal⁴, Z. Zhang⁵
¹Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, ³Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Northwestern University Transplant Surgery, Chicago, IL
*Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…