Articles tagged "Rejection"

2022 American Transplant Congress
Concordance of Kidney and Pancreas Rejection on Protocol and for Cause Biopsy in Simultaneous Kidney Pancreas Transplantation
P. Budhiraja, R. Heilman, H. Khamash, A. Jaramillo, D. Ramon, H. Me, J. Ninan, S. Reddy, s. S. Misra, H. Chakkera
Mayo Clinic, Phoenix, AZ
*Purpose: Our aim was to study the concordance rate of kidney and pancreas rejection in patients who received simultaneous kidney-pancreas transplantation (SKP) and its effects…
2022 American Transplant Congress
Single Cell RNA Sequencing Identifies Primarily Terminal Effector and Exhausted CD8⁺T Cells in Chronically Rejected Human Kidney Allografts
S. G. Yi¹, D. Zou¹, Y. Dai², Z. Zhao², W. Chen¹, A. Gaber¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX
*Purpose: Chronic renal allograft rejection often leads to irreversible damage, despite intensification of immunosuppression (ISN). T cell phenotypes in this clinical setting are not well…
2022 American Transplant Congress
The Impact of Soluble Human Leukocyte Antigen (HLA) on Renal Antibody-Mediated Rejection (AMR) After Simultaneous Liver Kidney Transplantation (SLKT)
H. Me¹, A. Jaramillo¹, D. Ramon¹, L. G. Olsen¹, R. Heilman¹, H. Khamash¹, T. Mohanakumar², R. Ravichandran²
¹Mayo Clinic, Phoenix, AZ, ²St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: The lower incidence of AMR and higher incidence of rejection-free grafts survival in SLKT recipients as compared to kidney transplant recipients have been clearly…
2022 American Transplant Congress
Longitudinal Monitoring of Simultaneous Pancreas and Kidney Transplant and Pancreas After Kidney Recipients Using Donor-Derived Cell-Free DNA
N. M. Ali¹, J. Miles², Z. Stewart³
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY, ³Transplant Institute, NYU Langone Health, New York, NM
*Purpose: The utility of dd-cfDNA in patients undergoing pancreas transplantation has not been well studied. Pancreatic rejection remains a major clinical concern. Early identification of…
2022 American Transplant Congress
Microvascular Inflammation without Antibody Mediated Rejection in Renal Transplantation
J. Bou Saba, R. Chowdhury, R. Mehta, K. I. Abou-Daya, S. Hariharan, A. Cherukuri
Thomas E. Starzl Transplantation Institute, UPMC, Pittsburgh, PA
*Purpose: Microvascular inflammation (MVI) defined by glomerulitis (g) and peritubular capillaritis (ptc) is a hallmark of ABMR in renal transplantation. The prevalence and significance of…
2022 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
V. Gorbacheva, R. Fan, S. Miyairi, W. M. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Immune responses to self antigens develop following organ transplantation. Multiple studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome.…
2022 American Transplant Congress
CCR2 Antagonism Blocks Microbiota Pro-Inflammatory Effects on Lymph Node Architecture
S. J. Gavzy¹, R. Lakhan², J. Iyyathurai², V. Saxena², Z. L. Lee², B. Ma², E. Mongodin², J. S. Bromberg²
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland, Baltimore, MD
*Purpose: Fecal microbiota transfer (FMT) of Desulfovibrio desulfuricans (Desulfo) triggers a pro-inflammatory immune state, causing decreased laminin α4:α5 ratios in the lymph node (LN), increased…
2022 American Transplant Congress
Evs from Patients with Amr Induce Tubular Senescence and Endmt Through Horizontal Transfer of Mirnas
R. Franzin¹, A. Stasi¹, F. Sallustio¹, S. Bruno², G. Merlotti³, M. Quaglia³, G. Grandaliano⁴, P. Pontrelli¹, J. Thurman⁵, G. Camussi², G. Stallone⁶, V. Cantaluppi³, L. Gesualdo¹, G. Castellano⁷
¹DETO, University of Bari, Bari, Italy, ²University of Turin, Turin, Italy, ³University of Piemonte Orientale, Novara, Italy, ⁴Università Cattolica Sacro Cuore, Rome, Italy, ⁵University of Colorado School of Medicine, Aurora, CO, ⁶University of Foggia, Foggia, Italy, ⁷University of Milan, Milan, Italy
*Purpose: Extracellular vesicles (EV) are emerging mediators in several diseases; however, their role in antibody-mediated allograft rejection (AMR) has been poorly investigated.*Methods: Plasma EVs from…
2022 American Transplant Congress
Histopathology at Diagnosis and One-Year Outcomes in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Preliminary Findings from the Paramour “Pediatric Renal AMR Outcomes” Study
R. Zahr¹, D. Puliyanda², I. Ashoor³, N. Hayde⁴, S. Solomon⁵, R. Engen⁶, L. Harshman⁷, C. Peterson⁸, S. McEwen⁹, A. Jain¹⁰, R. Garro¹¹, A. Mansuri¹², M. Kallash¹³, K. Twombley¹⁴
¹Pediatrics, University of Tennessee Health Science Center, Memphis, TN, ²Cedars-Sinai Med Ctr, West Hollywood, CA, ³Pediatrics, Lousiana State University, New Orleans, LA, ⁴Montefiore Medical Center, Bronx, NY, ⁵The Children's Hospital at Montefiore, New York, NY, ⁶Pediatrics, University of Wisconsin Madison, Madison, WI, ⁷University of Iowa Children's Hospital, Iowa City, IA, ⁸University of Utah, Salt Lake City, UT, ⁹University of Minnesota, Minneapolis, MN, ¹⁰Pediatrics, Wayne State University, Troy, MI, ¹¹Emory University, Atlanta, GA, ¹²Pediatrics, Augusta University, Augusta, GA, ¹³Pediatrics, The Ohio State Univesrity, Columbus, OH, ¹⁴Medical University of South Carolina, Charleston, SC
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft dysfunction leading to graft loss. There is a paucity of data regarding how…
2022 American Transplant Congress
The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation
K. Evans¹, K. Beermann¹, H. Lee², M. Harris¹, C. W. Frankel³, H. Berry¹, H. Ali³
¹Pharmacy, Duke Health, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC
*Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…