Articles tagged "Rejection"

2018 American Transplant Congress
Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging
T. Liao,¹ Y. Zhang,¹ J. Ren,² H. Zheng,¹ H. Zhang,² X. Liu,¹ T. Yin,² Q. Sun.¹
¹Organ Transplantation Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…
2018 American Transplant Congress
Depletion Resistant Effector Memory T Cells Mediate Thymoglobulin Refractory Allograft Rejection in Human Intestinal Transplant Recipients
O. Aguirre, B. Houlihan, A. Karabala, C. Cosentino, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. This study aimed to determine the mechanisms underlying T cell depletion-resistant moderate to severe acute cellular rejection (ACR) in intestinal transplantation (ITx) patients.B. A…
2018 American Transplant Congress
Precision Medicine for Determining the Efficacy of a Novel Belatacept Regimen
J. Shoji, J. Leung, E. Tavares, Q. Tang, F. Vincenti.
Transplant Nephrology, UCSF, San Francisco, CA.
IntroBelatacept is increasingly used as maintenance immunosuppression to improve long term outcomes in kidney transplant. Since acute rejection in patients on belatacept have been noted…
2018 American Transplant Congress
“Majority Rules”: A Method to Reduce Variability in Diagnosing Antibody Mediated Rejection in Renal Allograft Biopsies Using Banff 2013
B. Smith,¹ L. Cornell,¹ M. Smith,² C. Cortese,³ X. Geiger,³ C. Schinstock,¹ W. Kremers,¹ M. Stegall.¹
¹Mayo Clinic, Rochester, MN; ²Mayo Clinic, Scottsdale, AZ; ³Mayo Clinic, Jacksonville, FL.
Introduction: The Banff 2013 criteria for diagnosing antibody-mediated rejection (ABMR) includes three lesions: glomerulitis (g), peritubularitis (PTC), and chronic glomerulopathy (cg). The poor reproducibility of…
2018 American Transplant Congress
Donor-Specific Antibody Mediates Chronic, but Not Acute, Kidney Allograft Rejection in the Absence of Natural Killer Cells
T. Yagisawa, N. Dvorina, A. Valujskikh, W. Baldwin 3rd, R. Fairchild.
Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice transplanted…
2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
J. Nie,¹ B. Ramaswami,² X. Guo,³ R. Hoffman,² G. Chalasani.³
¹Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA.
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
2018 American Transplant Congress
Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection
M. Weir,¹ D. Hiller,² J. Yee,² A. Matas.³
¹University of Maryland School of Medicine, Baltimore, MD; ²CareDx, Brisbane, CA; ³University of Minnesota School of Medicine, Minneapolis, MN.
Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…
2018 American Transplant Congress
Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation
E. Ko,^1,2 B. Choi,^1,2 C. Park,^1,2 Y. Kim,^1,2 C. Yang,^1,2 B. Chung.^1,2
¹Transplant Research Center, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, College of Medicine, Seoul St.Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Background: Microvascular inflammation (MVI) is considered as a pathological marker for antibody-mediated rejection (AMR) in the presence of donor-specific antibody (DSA). We aimed to investigate…
2018 American Transplant Congress
Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation
C. Pham,¹ B. Pierce,¹ S. Bapat,² S. Kuten,¹ L. Moore,³ A. Gaber.³
¹Department of Pharmacy, Houston Methodist Hospital, Houston; ²College of Pharmacy, University of Houston, Houston; ³Department of Surgery, Houston Methodist Hospital, Houston.
Ubiquitous expression of vitamin D receptors on antigen-presenting cells has sparked interest into its immunomodulatory effects. While previous literature has described the effect of vitamin…
2018 American Transplant Congress
Melatonin Prolongs Heart Allograft Survival by Induction of Foxp3+ Regulatory T Cells
L. Liu, Q. Su, Y. Xiong, Z. Bi, H. Huang, Y. Peng, C. Wang.
The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
Objective: This study was aimed to investigate the effect of melatonin on heart allograft survival and explore the underlying mechanism. Methods and Results: Balb/c and…