Articles tagged "Rejection"

2022 American Transplant Congress
Impact of Delayed Graft Function in Donation After Circulatory Death Kidney Transplantation
J. Mello Offerni¹, H. Brar¹, D. Lee¹, M. Levine², M. Mandurah¹, S. Rim¹, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Donation after circulatory death (DCD) has been associated with higher rates of delayed graft function (DGF) when compared to donation after brain death (DBD).…
2022 American Transplant Congress
DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation
C. Testini¹, S. Bose¹, K. Liu¹, S. Kong¹, E. Flynn¹, M. Miovski¹, J. Leyva-Rangel¹, M. Laplante², J. Wedel¹, D. M. Briscoe¹
¹Boston Children's Hospital and Harvard Medical School, Boston, MA, ²Laval University, Quebec, QC, Canada
*Purpose: Recent studies have highlighted a paradigm whereby the maintenance of normal tissue homeostasis and the prevention of chronic inflammation is dependent on the active…
2022 American Transplant Congress
A Single-Center’s Outcomes of Combined Heart-Liver Transplantation
R. W. Lincoln¹, K. Kalvakuri², A. Guha², A. Bhimaraj², E. E. Suarez², A. Saharia³, C. M. Mobley³, F. Amirkhosravi³, J. Krisl¹
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²DeBakey Heart and Vascular Associates, Houston Methodist Hospital, Houston, TX, ³Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: The purpose of this study was to evaluate rejection outcomes in our combined heart-liver transplant (CHLT) recipients at 6 months.*Methods: This is a retrospective,…
2022 American Transplant Congress
Circulating Donor-Derived Cell-Free DNA: A Novel Non-Invasive Biomarker for Immune Surveillance in Vascularized Composite Allotransplantation
W. J. Rifkin¹, J. Trilles¹, P. S. Rabbani¹, O. C. Onuh¹, B. E. Gelb², D. J. Ceradini¹, E. D. Rodriguez¹
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to evaluate whether circulating donor-derived cell-free DNA (dd-cfDNA) could be used as a noninvasive biomarker to detect rejection…
2022 American Transplant Congress
Study Of Matrix Metalloproteinase (mmp) And Tissue Inhibitors Of Metalloproteinase (timp) Gene Polymorphisms In Renal Allograft Outcome
J. P. Tom¹, J. Singh¹, A. Sharma², R. Aggarwal¹, R. Nada³, R. Ramachandran⁴, S. Anand¹, R. Minz¹
¹Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ²Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ³Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ⁴Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
*Purpose: Our study aimed to find a role, if any, of functional gene polymorphisms of MMP and their inhibitors- TIMP in renal allograft outcome.*Methods: The…
2022 American Transplant Congress
Evaluation of Post-Transplant Angiotensin II Type 1 Receptor Antibodies, Donor-Derived Cell-Free DNA, and Rejection in Heart Transplant Recipients
B. Agegnehu¹, S. Sterling¹, R. Winstead¹, I. Tchoukina²
¹Pharmacy, VCU Health System, Richmond, VA, ²Advanced Heart Failure and Transplant Cardiology, VCU Health System, Richmond, VA
*Purpose: There is limited evidence evaluating the relationship between angiotensin II type 1 receptor antibodies (AT1R-Abs), donor-derived cell-free DNA (dd-cfDNA), and rejection in heart transplant…
2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
I. Sayin¹, D. Yin¹, D. Ghosh², M. Clark², A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…
2022 American Transplant Congress
A Sustained Injury Response by Regulatory T Cells (Treg) Contributes to Fibrosis to Promote Chronic Rejection After Heart Transplantation
J. Bou Saba¹, L. Fan¹, X. Zhang¹, T. Li¹, L. R. Mathews¹, G. Dwyer², E. Colon², M. J. Calderon³, K. E. Helfrich³, M. A. Ross³, S. C. Watkins³, H. Turnquist¹
¹Surgery, University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²Immunology, University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ³Cell Biology, University of Pittsburgh, Center for Biologic Imaging, Pittsburgh, PA
*Purpose: Chronic rejection (CR) results from the development of immunosuppressant-resistant allograft vasculopathy and fibrosis and remains a leading cause of recipient death one-year post-heart transplant…
2022 American Transplant Congress
Dd-cfdna Correlates With Acute Rejection In The Setting Of Bk Viremia After Kidney Transplantation
N. M. Ali¹, J. Miles², V. Tatapudi¹, R. Chand¹, R. Montgomery¹
¹NYU Langone Transplant Institute, New York, NY, ²CareDx, Brooklyn, NY
*Purpose: BK virus reactivation is common among kidney transplant recipients (KTRs) and is a risk factor for allograft loss. Currently, there is no clearly established…
2022 American Transplant Congress
Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation
B. Rocque¹, D. Sarode², A. Barbetta³, P. Singh⁴, C. Goldbeck⁴, C. Weaver⁵, O. Akbari⁴, R. Kohli⁵, J. Emamaullee⁶
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Keck School of Medicine of University of Southern California, Pasadena, CA, ³Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, ⁴Keck School of Medicine of USC, Los Angeles, CA, ⁵Childrens Hospital Los Angeles, Los Angeles, CA, ⁶University of Southern California, Los Angeles, CA
*Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…

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