Articles tagged "Rejection"

2022 American Transplant Congress
Differential Impact of Subclinical Kidney Transplant Rejection in Young Adults
S. Raza¹, G. Agarwal¹, H. Fatima¹, R. Gaston¹, V. Hauptfeld-Dolesjek¹, B. Julian¹, C. Kew¹, V. Kumar¹, S. Mehta¹, S. Ong¹, F. Rosenblum¹, G. Towns¹, R. Mannon², M. Seifert¹
¹School of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²College of Medicine, University of Nebraska, Omaha, NE
*Purpose: Serum creatinine, while an insensitive biomarker of allograft injury, is the current standard for assessing the stability of allograft function and guiding kidney transplant…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA Trends Before and After Rejection Vary Based on Timing of Rejection
C. Rebello¹, K. Guo¹, S. Park², B. Kinsella¹, L. Zhao¹, J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been used for acute rejection detection and trending levels may help predict future rejection and assess the adequacy of…
2022 American Transplant Congress
Detection of Early Graft Injury After Liver Transplantation with Blood-Bile Ratio of Tacrolimus: The TUBE Trial
M. M. Pascale¹, G. Bianco¹, L. Ferri¹, F. Giovinazzo¹, A. Liguori², G. Marrone², A. Grieco², S. Agnes¹
¹General Surgery and Liver Transplant Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy, ²Transplant Hepatology Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy
*Purpose: The aim of the“Tacrolimus in Bile”(TUBE)Trial is the creation of a laboratory parameter for the early detection of hepatic injury after liver transplant.*Methods: TUBE…
2022 American Transplant Congress
Impact of Delayed Graft Function in Donation After Circulatory Death Kidney Transplantation
J. Mello Offerni¹, H. Brar¹, D. Lee¹, M. Levine², M. Mandurah¹, S. Rim¹, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Donation after circulatory death (DCD) has been associated with higher rates of delayed graft function (DGF) when compared to donation after brain death (DBD).…
2022 American Transplant Congress
DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation
C. Testini¹, S. Bose¹, K. Liu¹, S. Kong¹, E. Flynn¹, M. Miovski¹, J. Leyva-Rangel¹, M. Laplante², J. Wedel¹, D. M. Briscoe¹
¹Boston Children's Hospital and Harvard Medical School, Boston, MA, ²Laval University, Quebec, QC, Canada
*Purpose: Recent studies have highlighted a paradigm whereby the maintenance of normal tissue homeostasis and the prevention of chronic inflammation is dependent on the active…
2022 American Transplant Congress
A Single-Center’s Outcomes of Combined Heart-Liver Transplantation
R. W. Lincoln¹, K. Kalvakuri², A. Guha², A. Bhimaraj², E. E. Suarez², A. Saharia³, C. M. Mobley³, F. Amirkhosravi³, J. Krisl¹
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²DeBakey Heart and Vascular Associates, Houston Methodist Hospital, Houston, TX, ³Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: The purpose of this study was to evaluate rejection outcomes in our combined heart-liver transplant (CHLT) recipients at 6 months.*Methods: This is a retrospective,…
2022 American Transplant Congress
Circulating Donor-Derived Cell-Free DNA: A Novel Non-Invasive Biomarker for Immune Surveillance in Vascularized Composite Allotransplantation
W. J. Rifkin¹, J. Trilles¹, P. S. Rabbani¹, O. C. Onuh¹, B. E. Gelb², D. J. Ceradini¹, E. D. Rodriguez¹
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to evaluate whether circulating donor-derived cell-free DNA (dd-cfDNA) could be used as a noninvasive biomarker to detect rejection…
2022 American Transplant Congress
Study Of Matrix Metalloproteinase (mmp) And Tissue Inhibitors Of Metalloproteinase (timp) Gene Polymorphisms In Renal Allograft Outcome
J. P. Tom¹, J. Singh¹, A. Sharma², R. Aggarwal¹, R. Nada³, R. Ramachandran⁴, S. Anand¹, R. Minz¹
¹Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ²Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ³Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ⁴Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
*Purpose: Our study aimed to find a role, if any, of functional gene polymorphisms of MMP and their inhibitors- TIMP in renal allograft outcome.*Methods: The…
2022 American Transplant Congress
Evaluation of Post-Transplant Angiotensin II Type 1 Receptor Antibodies, Donor-Derived Cell-Free DNA, and Rejection in Heart Transplant Recipients
B. Agegnehu¹, S. Sterling¹, R. Winstead¹, I. Tchoukina²
¹Pharmacy, VCU Health System, Richmond, VA, ²Advanced Heart Failure and Transplant Cardiology, VCU Health System, Richmond, VA
*Purpose: There is limited evidence evaluating the relationship between angiotensin II type 1 receptor antibodies (AT1R-Abs), donor-derived cell-free DNA (dd-cfDNA), and rejection in heart transplant…
2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
I. Sayin¹, D. Yin¹, D. Ghosh², M. Clark², A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…

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