2022 American Transplant Congress
Clinical Significances Of Anti-collagen Type I And Type Iii Antibodies In Antibody-mediated Rejection
*Purpose: It is important to determine the clinical significance of non-human leukocyte antigen (HLA) antibodies and their association with antibody-mediated rejection (ABMR) of kidney allografts.*Methods:…2022 American Transplant Congress
Very Low Frequency of Pathological Findings in One-Year Protocol Biopsies of Low-Risk Kidney Transplant Recipients – Results from the Nordic Protocol Biopsy Study
*Purpose: The clinical usefulness of kidney graft protocol biopsies have been debated. We studied the frequency of borderline and T-cell-mediated rejection (TCMR) in one-year protocol…2022 American Transplant Congress
Hypomethylated Regulatory Regions in Immune Signaling Genes Characterize Rejection Prone Pediatric Liver Transplant (LT) Recipients
*Purpose: Transcriptional regulation of LT rejection may reveal novel predictive and therapeutic targets. To identify signaling pathways which are differentially regulated by DNA methylation in…2022 American Transplant Congress
Use of Everolimus and Reduced Calcineurin Inhibitors in Bk Nephropathy: Insights from Follow-Up and Surveillance Biopsies
Cleveland Clinic, Cleveland, OH
*Purpose: BK virus-associated nephropathy (BKVAN) is a clinically important entity that results in an allograft loss in kidney transplant recipients (KTRs). Mammalian target of rapamycin…2022 American Transplant Congress
Non-HLA Autoantibodies: The Hidden Offenders to Double the Trouble
*Purpose: There is emerging evidence suggesting non-HLA autoantibodies triggered after the graft injury. Here, we report 3 cases where non-HLA autoantibodies were positive after 3…2022 American Transplant Congress
Comprehensive Profiling of Monocytes During Cellular (TCMR) or Mixed Antibody-Mediated Rejection (ABMR) After Kidney Transplantation
*Purpose: Monocytes play an important role in the immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate…2022 American Transplant Congress
Development and Validation of an Integrative DD-CFDNA System to Predict Allograft Rejection: A Population Based Study
Paris Translational Center for Organ Transplantation, Paris, France
*Purpose: Post-transplantation patient care requires development and validation of non-invasive biomarkers to improve allograft monitoring and prevention from unnecessary and costly biopsies. Reports have suggested…2022 American Transplant Congress
Racial Differences in the Predictability of Donor-Derived Cell-Free DNA Among Renal Transplant Recipients
1Rush University Medical Center, Chicago, IL, 2CareDx, Brisbane, CA
*Purpose: Donor-Derived Cell-Free DNA (dd-cfDNA) is used to monitor for allograft rejection following renal transplantation. Baseline dd-cfDNA is higher in African American (AA) patients compared…2022 American Transplant Congress
Steroid-Free Living Donor Liver Transplantation Using Rabbit Antithymocyte Globulin Induction Reduces Incidence of Acute Cellular Rejection
*Purpose: The efficacy of steroid-free immunosuppression protocols using rabbit antithymocyte globulin (RATG) induction with tacrolimus minimization has previously been described in deceased donor liver transplantation.…2022 American Transplant Congress
Peripheral Blood Immune Cell Profiles of Corneal Transplant with and without Acute Rejection
*Purpose: Acute rejection (AR) of allogeneic corneal transplantation (CT) has a profound effect on subsequent graft survival, indicating that immunological damage is often not fully…
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