ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Recurrence"

  • 2018 American Transplant Congress

    Treatment Outcomes of Recurrent Primary Focal Segmental Glomerulosclerosis (FSGS) after Kidney Transplantation

    R. Aguiar,1 F. Pereira,2 A. Gasparini,3 P. Chowdhury,1 D. Game,1 D. Moutzouris.1

    1Department of Nephrology and Transplantation, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom; 2Department of Renal Medicine, Hospital Dr. Fernando Fonseca, Lisbon, Portugal; 3Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

    Introduction: Primary FSGS can recur in the renal allograft and is associated with poor graft outcomes. There is no established therapeutic intervention to prevent or…
  • 2018 American Transplant Congress

    Outcomes of Antiviral Treatment (AVT) in Hepatitis C Virus (HCV) Liver Transplant (LT) Patients off Immunosuppression (IS) in Direct Acting Antivirals (DAA) Era

    E. Agudelo,1,2 I. Campos-Varela,3 N. Terrault.1,2

    1Medicine, University of California San Francisco, San Francisco, CA; 2Surgery, University of California San Francisco, San Francisco, CA; 3Internal Medicine, Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

    Background: Clearance of HCV under AVT, including DAAs, has been associated with higher risk of rejection, possibly due to the changing immunological environment within the…
  • 2018 American Transplant Congress

    Redo Kidney Transplant in FSGS

    J. Verbesey, A. Javaid, S. Yi, G. Vranic, A. Gilbert, P. Abrams, S. Ghasemian, J. Moore, B. Thomas, M. Cooper, B. Javaid.

    Kidney and Pancreas Transplant Program, MedStar Georgetown Transplant Institute, Washington, DC.

    Objective: Analyze risk of graft failure due to recurrent FSGS in patients with prior failed kidney transplants under consideration for a subsequent transplant.Results: We identified…
  • 2018 American Transplant Congress

    Hepatitis C Recurrence after Liver Transplant: A Comparison of Antibody Induction versus No Antibody Induction

    S. Patel, J. Jin, E. Benedetti, P. West-Thielke.

    University of Illinois Hospital and Health Sciences System, Chicago.

    Background: Hepatitis C virus (HCV) recurrence after orthotopic liver transplant (OLT) is universal and exhibits accelerated progression to cirrhosis. Progression can be mitigated by new…
  • 2018 American Transplant Congress

    Thirty-Six Consecutive Kidney Transplants in Recipients with Atypical Hemolytic Uremic Syndrome: A Single-Centre Experience

    E. Favi,1 G. Ardissino,2 D. Cresseri,3 J. Brocca,1 S. Testa,4 F. Tel,4 A. Giussani,1 C. Colico,1 C. Beretta,1 M. Ferraresso.1

    1Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; 2Centre for HUS Prevention, Control and Management, Fondazione IRCCS Ca' Granda, Milan, Italy; 3Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy; 4Pediatric Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy.

    Background. Due to high recurrence rate, poor kidney transplant (KTx) survival has been reported for recipients with atypical hemolytic uremic syndrome (aHUS). More recently, prophylaxis…
  • 2018 American Transplant Congress

    Impact of Antecedent Malignancy on Kidney Transplant Outcomes: Patient, Graft, and Cancer-Free Survival

    O. Serrano,1 S. Mongin,2 D. Berglund,1 D. Vock,3 S. Chinnakotla,1 T. Dunn,1 E. Finger,1 R. Kandaswamy,1 T. Pruett,1 A. Matas.1

    1Surgery, University of Minnesota, Minneapolis, MN; 2Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, Minneapolis, MN; 3Biostatistics, University of Minnesota, Minneapolis, MN.

    OBJECTIVE: Non-skin pretransplant malignancy (NSPTM) has historically been considered a relative contraindication to kidney transplantation (KT). In addition to the conventional risk factors for cancer,…
  • 2018 American Transplant Congress

    HLA-DR4 Matching and Hepatocellular Carcinoma Recurrence after Liver Transplantation

    M. Xu, S. Garcia-Aroz, N. Vachharajani, Y. Lin, W. Chapman.

    Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO.

    PURPOSE: The phenomenon of graft versus host disease after orthotopic liver transplantation (OLT) is estimated at approximately 1-2%, suggesting that under some circumstances, the graft…
  • 2018 American Transplant Congress

    Recovery of Wild-Type Genotype after Documented Ganciclovir-Resistance in Transplant Recipients with Recurrent CMV Viremia

    J. Fose, M. Jorgenson, Z. Degrave, R. Redfield, J. Smith, D. Mandelbrot.

    University of Wisconsin Hospital, Madison; University of Wisconsin School of Medicine and Public Health, Madison.

    Purpose: Ganciclovir-resistant cytomegalovirus (GR-CMV) is serious complication after transplantation. Recurrence after primary GR-CMV infection is common, with literature defined rates of approximately 20-30%. It is…
  • 2017 American Transplant Congress

    Maribavir for Treatment of Cytomegalovirus Infections Resistant or Refractory to Ganciclovir or Foscarnet in Solid Organ Transplant Recipients: A Phase 2 Study.

    M. Pereira,1 F. Silveira,2 G. Papanicolaou,3 A. Langston,4 R. Avery,5 A. Wijatyk,6 J. Wu,6 M. Boeckh,7 F. Marty,8 S. Villano.9

    1Columbia University Medical Center, New York, NY; 2University of Pittsburgh Medical Center, Pittsburgh, PA; 3Memorial Sloan Kettering Cancer Center, New York, NY; 4Winship Cancer Institute, Atlanta, GA; 5Johns Hopkins University, Baltimore, MD; 6Shire, Lexington, MA; 7Fred Hutchinson Cancer Research Center, Seattle, WA; 8Brigham and Women's Hospital, Boston, MA; 9Shire (At Time of Study), Wayne, PA

    Study NCT01611974 assessed safety, tolerability, and antiviral activity of maribavir (MBV) for treatment of resistant or refractory (R/R) CMV infections among transplant recipients. Those aged…
  • 2017 American Transplant Congress

    Eculizumab Dose Reduction Is Safe by Monitoring Eculizumab Pre-Dose Level and Functional Complement Assays.

    M. Gelens,1 T. Havenith,2 J. Damoiseaux,3 M. Christiaans.1

    1Internal Medicine, MUMC, Maastricht, Netherlands; 2Clinical Pharmacy, MUMC, Maastricht, Netherlands; 3Central Diagnostic Laboratory, MUMC, Maastricht, Netherlands

    Background & aims: Untreated atypical haemolytic syndrome (aHUS) leads to ESRD and may recur after renal transplantation. Eculizumab (Ecu), a humanized antibody inhibiting terminal C5…
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