ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Reactive oxygen species"

  • 2019 American Transplant Congress

    Ceria-Zirconia Nanoparticles as an Enhanced Antioxidant Attenuates Apoptosis of Human Kidney Proximal Tubular Epithelial Cells in Hypoxia

    S. Yoon1, K. Yoon2, S. Hong3, S. Yun1, W. Hwang1, J. Moon4, J. Lee1, H. Jeon1

    1Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, 2Hannam University, Daejeon, Korea, Republic of, 3Chemistry, Hannam University, Daejeon, Korea, Republic of, 4General Surgery, Konyang University Hospital, Daejeon, Korea, Republic of

    *Purpose: Ischemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of delayed graft function and graft rejection. Various mechanisms have been…
  • 2019 American Transplant Congress

    The Adapter Protein TSAd Regulates Mitochondrial Lck Activity and is Potent to Enhance Immunoregulation Following Transplantation

    J. Wedel1, M. P. Stack1, T. Seto1, K. Liu1, I. E. Stillman2, D. M. Briscoe1

    1Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 2Department of Pathology, Beth Israel Deaconess Center, Harvard Medical School, Boston, MA

    *Purpose: T cell Specific Adaptor Protein (TSAd, encoded by the SH2D2A gene) is an intracellular adapter molecule that binds Lck and functions to elicit T…
  • 2018 American Transplant Congress

    Klotho Enhances FoxO3-Mediated Manganese Superoxide Dismutase Expression by Negatively Regulating PI3K/AKT Pathway during Tacrolimus-Induced Oxidative Stress

    S. Lim,1 K. Luo,1 J. Il,1 Y. Shin,1 E. Ko,1,2 B. Chung,1,2 C. Yang.1,2

    1Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea; 2Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

    Mammalian members of the forkhead box protein O (FoxO) class of transcription factors are implicated in the regulation of oxidative stress, and FoxO proteins are…
  • 2017 American Transplant Congress

    Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.

    N. Rogers,1,2,3 D. Meijles,3 P. Pagano,3 J. Isenberg.3

    1Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, NSW, Australia; 2Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA; 3Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

    Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
  • 2017 American Transplant Congress

    The Beneficial Effect of Janus Kinase 3 Inhibitor on Transplanted Islet via Protection from Oxidative Stress-Induced β Cell Death.

    S.-J. Kang,1,2,3,4 H. Chung,1,2,3,4 S. Lee,1,2,3,4 J.-S. Shin,1,3,5 H.-J. Kim,1,2,3,4 J.-M. Kim,1,3,5 B.-H. Min,1,3,5 S. Choi,1,2,3,4 C.-G. Park.1,2,3,4,5

    1Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; 2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; 3Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; 4Department of Biomedical Sciences, Seoul National University, Seoul, Korea; 5Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea

    Janus kinase 3 (JAK3) is one of the molecules that make up the JAK-STAT signaling pathway that regulates numerous 40 cytokines. Thus, this cascade can…
  • 2017 American Transplant Congress

    Nox4 and Oxidative Stress Mediate TGF-β1 Induced Human Kidney Proximal Cell Apoptosis in Ischemic Reperfusion Injury.

    S.-H. Yoon,1 S. Cho,1 D.-I. Kim,1 S.-R. Yoon,1 W.-M. Hwang,1 S.-L. Yu,2 J. Kang.2

    1Internal Medicine, Konyang University, Deajeon, Republic of Korea; 2Pharmacology, Konyang University, Daejeon, Republic of Korea

    AimsIschemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of cell death and graft rejection. In this study, we investigated whether…
  • 2017 American Transplant Congress

    The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.

    G. Weber,1 N. Ambrosi,2 F. Caro,2 S. Beltramino,1 A. Fernández,1 I. Cabrera,1 G. Hilchenbach,1 D. Fernandez,1 C. Incardona,3 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; 3Fundación GADOR, Buenos Aires, Argentina

    A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…
  • 2017 American Transplant Congress

    Mitochondrial Dysfunction Is a Common Feature of Injury in Donor Kidneys After Brain and Circulatory Death.

    M. Lo Faro,1 M. Akhtar,1 H. Huang,1 M. Kaisar,1 R. Rebolledo,2 K. Morten,1 L. Heather,1 A. Dona,3 H. Leuvenink,2 S. Fuggle,1 B. Kessler,1 C. Pugh,1 R. Ploeg.1

    1University of Oxford, Oxford, United Kingdom; 2University of Groningen, Groningen, Netherlands; 3University of Sydney, Sydney, Australia

    The pro-coagulatory and pro-inflammatory environment in donors after brain death (DBD) and warm ischemia in donors after circulatory death (DCD) can cause injury to target…
  • 2016 American Transplant Congress

    Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.

    R. Kapoor, N. Sheerin, J. Kirby.

    Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.

    Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…
  • 2016 American Transplant Congress

    Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.

    M. Lo Faro,1 M. Akhtar,1 H. Huang,1 M. Kaisar,1 R. Robolledo,2 K. Morten,1 L. Heather,1 A. Dona,3 H. Leuvenink,2 S. Fuggle,1 B. Kessler,1 C. Pugh,1 R. Ploeg.1

    1University of Oxford, Oxford, United Kingdom; 2University of Groningen, Groningen, Netherlands; 3University of Sydney, Sydney, Australia.

    Donation after brain death (DBD) organ donors remain an important source for kidney transplantation. However, brain death affects donor organs rendering them susceptible to ischemia…
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