Articles tagged "Protocol biopsy"

2016 American Transplant Congress
A Systematic Over View of Five Year Results of Serial Protocol Kidney Transplant Biopsies.
A. Geraedts, M. Tavakol, F. Vincenti, S. Chandran, Z. Laszik, B. Lee, J. Roberts, M. Sarwal.
Surgery, UCSF, San Francisco, CA.
Background: Protocol biopsies can detect sub-clinical rejection. With declining rates of clinical acute rejection, a systematic review of protocol biopsies can provide clues about other…
2015 American Transplant Congress
Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection
T. Tsuji,¹ M. Yanai,¹ H. Itami,¹ Y. Ishii,¹ M. Akimoto,¹ N. Fukuzawa,² H. Harada,² Y. Fukasawa.¹
¹Demartment of Pathology, Sapporo City General Hospital, Sapporo, Japan; ²Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan.
Aim:Chronic active antibody-mediated rejection (chronic ABMR) is one important cause of late-stage renal allograft loss. However, few reports have used protocol biopsy to observe changes…
2015 American Transplant Congress
A Clinical Signature Surrogate of Histological Lesions to Avoid Unnecessary One Year Surveillance Biopsy After Renal Transplantation
E. Dantan, K. Renaudin, S. Brouard, A. Huneau, C. Paul, M. Giral.
Biostatitics, Nantes University, Nantes, France; Anatomo Pathology, University Hospital, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Biostatistics, Nantes University, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Nephrology, University Hospital, Nantes, France.
Introduction:Surveillance biopsy remains debated after renal transplantation since the histological diagnostic do not lead to clear therapeutic recommendations. The main objective for this study was…
2015 American Transplant Congress
Correlation Between C3d-Binding De Novo Donor Specific HLA Antibodies and Rejection in Kidney Transplant Recipients
M. Cusick, K. Haarberg, J. Friedewald, A. Tambur.
Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Donor specific antibodies (DSA) directed against HLA arising de novo post-kidney transplant are a major cause of graft loss, termed antibody mediated rejection (AMR). Currently,…
2015 American Transplant Congress
Fibrosis, Not Quantitative NGAL-Staining, in Day-10 Protocol Biopsies Predicts Prolonged Duration of Functional Delayed Graft Function in a Cohort of DCD Kidney Transplant Recipients
J. Bank,¹ M. Reinders,¹ M. Mallat,¹ N. Schlagwein,¹ S. van der Kooij,¹ D. van Gijlswijk,¹ I. Bajema,² C. van Kooten,¹ H. de Fijter.¹
¹Nephrology, LUMC, Leiden, Netherlands; ²Pathology, LUMC, Leiden, Netherlands.
Introduction: Extended criteria deceased kidneys are associated with prolonged delayed graft function and worse patient survival. Therefore it is important to identify factors in marginal…
2015 American Transplant Congress
Validation of a Peripheral Blood Gene Expression Profile for SubClinical Acute Rejection in Kidney Transplant Recipients – Findings from the CTOT 08 Study
J. Friedewald,¹ S. Kurian,² T. Gelbart,² D. Salomon,² M. Abecassis.¹
¹Northwestern University, Chicago; ²Scripps Research Institute, La Jolla.
Background: Sub-clinical acute rejection (SCAR) is histologic acute cellular rejection in the presence of a normal/stable serum creatinine, and is associated with worse graft survival.…
2015 American Transplant Congress
Impact of Subclinical Rejection (SCR) and Acute Clinical (ACR) in Renal Transplant Recipients
R. Mehta, P. Sood, A. Cherukuri, S. Chen, G. Mour, C. Wu, N. Shah, C. Puttarajappa, P. Randhawa, A. Tevar, S. Hariharan.
University of Pittsburgh Medical Center, Pittsburgh, PA.
The importance of diagnosing subclinical rejection and its short and long term impact remains controversial.We prospectively evaluated 296 patients who had a kidney transplant at…