ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Protocol biopsy"

  • 2016 American Transplant Congress

    Replicative Senescence and Arteriosclerosis After Kidney Transplantation.

    K. De Vusser,1 D. Martens,2 E. Lerut,3 D. Kuypers,1 T. Nawrot,2 M. Naesens.1

    1Department of Nephrology and Renal Transplantation, UZ Leuven, Leuven, Belgium; 2Department of Imaging and Pathology, KULeuven, Leuven, Belgium; 3Centre for Environmental Sciences, U Hasselt, Hasselt, Belgium.

    BackgroundReplicative senescence is associated with telomere shortening. In native kidneys, obtained prior to transplantation, we recently described and validated a significant association between shorter intrarenal…
  • 2015 American Transplant Congress

    Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection

    T. Tsuji,1 M. Yanai,1 H. Itami,1 Y. Ishii,1 M. Akimoto,1 N. Fukuzawa,2 H. Harada,2 Y. Fukasawa.1

    1Demartment of Pathology, Sapporo City General Hospital, Sapporo, Japan; 2Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan.

    Aim:Chronic active antibody-mediated rejection (chronic ABMR) is one important cause of late-stage renal allograft loss. However, few reports have used protocol biopsy to observe changes…
  • 2015 American Transplant Congress

    A Clinical Signature Surrogate of Histological Lesions to Avoid Unnecessary One Year Surveillance Biopsy After Renal Transplantation

    E. Dantan, K. Renaudin, S. Brouard, A. Huneau, C. Paul, M. Giral.

    Biostatitics, Nantes University, Nantes, France; Anatomo Pathology, University Hospital, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Biostatistics, Nantes University, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Nephrology, University Hospital, Nantes, France.

    Introduction:Surveillance biopsy remains debated after renal transplantation since the histological diagnostic do not lead to clear therapeutic recommendations. The main objective for this study was…
  • 2015 American Transplant Congress

    Correlation Between C3d-Binding De Novo Donor Specific HLA Antibodies and Rejection in Kidney Transplant Recipients

    M. Cusick, K. Haarberg, J. Friedewald, A. Tambur.

    Comprehensive Transplant Center, Northwestern University, Chicago, IL.

    Donor specific antibodies (DSA) directed against HLA arising de novo post-kidney transplant are a major cause of graft loss, termed antibody mediated rejection (AMR). Currently,…
  • 2015 American Transplant Congress

    Fibrosis, Not Quantitative NGAL-Staining, in Day-10 Protocol Biopsies Predicts Prolonged Duration of Functional Delayed Graft Function in a Cohort of DCD Kidney Transplant Recipients

    J. Bank,1 M. Reinders,1 M. Mallat,1 N. Schlagwein,1 S. van der Kooij,1 D. van Gijlswijk,1 I. Bajema,2 C. van Kooten,1 H. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2Pathology, LUMC, Leiden, Netherlands.

    Introduction: Extended criteria deceased kidneys are associated with prolonged delayed graft function and worse patient survival. Therefore it is important to identify factors in marginal…
  • 2015 American Transplant Congress

    Validation of a Peripheral Blood Gene Expression Profile for SubClinical Acute Rejection in Kidney Transplant Recipients – Findings from the CTOT 08 Study

    J. Friedewald,1 S. Kurian,2 T. Gelbart,2 D. Salomon,2 M. Abecassis.1

    1Northwestern University, Chicago; 2Scripps Research Institute, La Jolla.

    Background: Sub-clinical acute rejection (SCAR) is histologic acute cellular rejection in the presence of a normal/stable serum creatinine, and is associated with worse graft survival.…
  • 2015 American Transplant Congress

    Impact of Subclinical Rejection (SCR) and Acute Clinical (ACR) in Renal Transplant Recipients

    R. Mehta, P. Sood, A. Cherukuri, S. Chen, G. Mour, C. Wu, N. Shah, C. Puttarajappa, P. Randhawa, A. Tevar, S. Hariharan.

    University of Pittsburgh Medical Center, Pittsburgh, PA.

    The importance of diagnosing subclinical rejection and its short and long term impact remains controversial.We prospectively evaluated 296 patients who had a kidney transplant at…
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