ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Protocol biopsy"

  • 2020 American Transplant Congress

    Immunohistochemical and Molecular Detection of NK Cells in Kidney Allografts with Antibody Mediated Rejection

    E. Farkash, J. Barnes, S. Anand

    Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: Molecular signatures specific to Natural Killer (NK) cells are closely associated with antibody mediated rejection (AMR) in transplant biopsies. We have developed an immunohistochemical…
  • 2019 American Transplant Congress

    When to Hold: Apixaban in Renal Transplant Recipients

    V. H. Do1, D. Haakinson2, K. D. Belfield1

    1Yale New Haven Hospital, New Haven, CT, 2Yale School of Medicine, New Haven, CT

    *Purpose: Renal transplant recipients (RTRs) may develop deep venous thrombosis (DVT), pulmonary embolism (PE), or atrial fibrillation requiring treatment with oral anticoagulation. There is limited…
  • 2019 American Transplant Congress

    Impact of Six-Month Surveillance Biopsies and Monitoring on 2-Year Outcomes in Pediatric Renal Transplant Recipients

    J. Lyons1, D. Ranch2, R. Hall1, P. Maxwell1, K. Hitchman2, B. Crowther1

    1University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: Evaluate the utility of surveillance biopsies on post-transplant outcomes.*Methods: A retrospective single center chart review of pediatric renal transplant recipients from 01/2011-10/2015 was conducted.…
  • 2019 American Transplant Congress

    Effect of Race and Antibody-Mediated Injury on Outcomes after Early Subclinical Inflammation

    E. P. Kasik, M. E. Seifert, M. Bernard, G. Agarwal, H. Fatima, R. Gaston, B. Julian, C. Kew, V. Kumar, S. Mehta, S. Ong, F. Rosenblum, G. Towns, R. B. Mannon

    University of Alabama, Birmingham, AL

    *Purpose: The impact of subclinical inflammation (SCI) on transplant outcomes has been variable, based on previous studies in homogeneous cohorts with relatively low immunologic risk.…
  • 2019 American Transplant Congress

    Recurrent Diabetic Nephropathy Despite Intensive Glycemic Control: An Observational Cohort Study

    M. Coemans, E. Van Loon, E. Lerut, D. Kuypers, B. Sprangers, P. Gillard, C. Mathieu, G. Verbeke, M. Naesens

    KU Leuven, Leuven, Belgium

    *Purpose: After kidney transplantation, recurrence of diabetic nephropathy has been reported. The presentation and kinetics of recurrent diabetic nephropathy and its risk factors remain however…
  • 2019 American Transplant Congress

    Humoral Immune Responses to Kidney Associated Non-HLA Antigens is Not Associated with Progression to Chronic Immune Injury in Kidney Transplant Recipients

    S. Sukumaran Nair1, R. Ravichandran2, R. Heilman1, A. Jaramillo1, D. Ramon1, M. Buras1, B. Kaplan1, T. Mohanakumar2

    1Mayo Clinic, Phoenix, AZ, 2St. Joseph’s Hospital, Phoenix, AZ

    *Purpose: Development of donor specific anti-HLA (DSA) although is a known risk factor for Chronic immune injury (CII), it is undetectable in many patients with…
  • 2019 American Transplant Congress

    IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial

    S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Joanes, F. Vincenti

    UCSF, San Francisco, CA

    *Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…
  • 2019 American Transplant Congress

    Impact Of Subclinical Bk Virus-associated Nephropathy In High-risk Recipients

    M. E. Seifert, E. P. Kasik, M. Bernard, G. Agarwal, H. Fatima, R. Gaston, B. Julian, C. Kew, V. Kumar, S. Mehta, S. Ong, F. Rosenblum, G. Towns, R. B. Mannon

    University of Alabama, Birmingham, AL

    *Purpose: BK virus-associated nephropathy (BKVAN) is a major contributor to kidney transplant failure. Surveillance of serum and urine for the BKV genome has been incorporated…
  • 2019 American Transplant Congress

    Surveillance Biopsy Utilization Reported Higher In Transplant Centers Performing Over 100 Kidney Transplants Per Year.

    D. M. Lee1, R. First1, S. Rose1, M. Abecassis2

    1Transplant Genomics Inc, Mansfield, MA, 2Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: To assess the frequency of surveillance biopsies in kidney transplant patients in transplant centers performing greater than 100 transplants per year, and to compare…
  • 2019 American Transplant Congress

    Subclinical Rejection by Biopsy or Gene Expression Profile Predicts Long Term Kidney Function in Patients in the CTOT08 Trial

    R. Heilman1, D. Taber2, K. Guo3, S. Brietigam3, j. charette3, S. Kurian4, M. Abecassis3, J. Friedewald3

    1Mayo Clinic AZ, Scottsdale, AZ, 2MUSC, Charleston, SC, 3Northwestern University, Chicago, IL, 4Scripps, La Jolla, CA

    *Purpose: The CTOT08 trial showed that either histological subAR or positive gene expression profile (GEP) in the blood associated with histological subAR correlated with a…
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