Articles tagged "Protocol biopsy"

2020 American Transplant Congress
Analysis of 1000 Protocol Kidney Biopsies: Complications, Benefits, and Predictive Potential of Prior Sensitization
M. Eslami¹, J. Patel², S. Karzai¹, D. T. Collins¹, C. Liu¹, J. Jonsson¹, R. Wali¹, J. B. Piper¹
¹Surgery, Inova Fairfax Hospital, Falls Church, VA, ²General Surgery, Pennsylvania State University, State College, PA
*Purpose: Protocol biopsy of kidney transplants can allow for early recognition of treatable findings, both immunologic and non-immunologic. This comes with the risk of biopsy…
2019 American Transplant Congress
Recurrent Diabetic Nephropathy Despite Intensive Glycemic Control: An Observational Cohort Study
M. Coemans, E. Van Loon, E. Lerut, D. Kuypers, B. Sprangers, P. Gillard, C. Mathieu, G. Verbeke, M. Naesens
KU Leuven, Leuven, Belgium
*Purpose: After kidney transplantation, recurrence of diabetic nephropathy has been reported. The presentation and kinetics of recurrent diabetic nephropathy and its risk factors remain however…
2019 American Transplant Congress
Humoral Immune Responses to Kidney Associated Non-HLA Antigens is Not Associated with Progression to Chronic Immune Injury in Kidney Transplant Recipients
S. Sukumaran Nair¹, R. Ravichandran², R. Heilman¹, A. Jaramillo¹, D. Ramon¹, M. Buras¹, B. Kaplan¹, T. Mohanakumar²
¹Mayo Clinic, Phoenix, AZ, ²St. Joseph’s Hospital, Phoenix, AZ
*Purpose: Development of donor specific anti-HLA (DSA) although is a known risk factor for Chronic immune injury (CII), it is undetectable in many patients with…
2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Joanes, F. Vincenti
UCSF, San Francisco, CA
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…
2019 American Transplant Congress
Impact Of Subclinical Bk Virus-associated Nephropathy In High-risk Recipients
M. E. Seifert, E. P. Kasik, M. Bernard, G. Agarwal, H. Fatima, R. Gaston, B. Julian, C. Kew, V. Kumar, S. Mehta, S. Ong, F. Rosenblum, G. Towns, R. B. Mannon
University of Alabama, Birmingham, AL
*Purpose: BK virus-associated nephropathy (BKVAN) is a major contributor to kidney transplant failure. Surveillance of serum and urine for the BKV genome has been incorporated…
2019 American Transplant Congress
Surveillance Biopsy Utilization Reported Higher In Transplant Centers Performing Over 100 Kidney Transplants Per Year.
D. M. Lee¹, R. First¹, S. Rose¹, M. Abecassis²
¹Transplant Genomics Inc, Mansfield, MA, ²Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: To assess the frequency of surveillance biopsies in kidney transplant patients in transplant centers performing greater than 100 transplants per year, and to compare…
2019 American Transplant Congress
Subclinical Rejection by Biopsy or Gene Expression Profile Predicts Long Term Kidney Function in Patients in the CTOT08 Trial
R. Heilman¹, D. Taber², K. Guo³, S. Brietigam³, j. charette³, S. Kurian⁴, M. Abecassis³, J. Friedewald³
¹Mayo Clinic AZ, Scottsdale, AZ, ²MUSC, Charleston, SC, ³Northwestern University, Chicago, IL, ⁴Scripps, La Jolla, CA
*Purpose: The CTOT08 trial showed that either histological subAR or positive gene expression profile (GEP) in the blood associated with histological subAR correlated with a…
2019 American Transplant Congress
Use of TruGraf Serial Testing for Confirming Stability in Kidney Transplant Patients with Stable Renal Function
V. Peddi¹, C. Schieve², S. Rose², M. First²
¹California Pacific Med Ctr, San Francisco, CA, ²Transplant Genomics Inc, Mansfield, MA
*Purpose: The objectives of this study were to model serial TruGraf testing in stable kidney transplant recipients and to demonstrate the potential clinical utility of…
2019 American Transplant Congress
C1q Dominant Deposits in Renal Transplant Biopsies Are Not Associated with Allograft Dysfunction
A. Babu¹, S. Williamson², N. Khoury¹, M. Safwan¹, A. Patel¹
¹Transplant Institute, Henry Ford Hospitals, Detroit, MI, ²Pathology Surgical, Henry Ford Hospitals, Detroit, MI
*Purpose: Complement deposition in renal allograft biopsies and native kidneys may represent an ongoing inflammatory process. We studied the significance of incidental finding of predominant…
2019 American Transplant Congress
Clinical Features of IgA Nephropathy Recurrence after Kidney Transplantation
H. HIGUCHI¹, K. Hotta², H. Harada¹, Y. Wada¹, A. Mitsuke¹, D. Iwami², N. Shinohara²
¹Urology and Kidney transplant surgery, Sapporo General Hospital, Sapporo, Japan, ²Urology, Hokkaido University, Sapporo, Japan
*Purpose: Recurrence of IgA nephropathy (IgAN) is one of the major cause of kidney graft loss. The clinical features of disease recurrence after kidney transplantation…