ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Protocol biopsy"

  • 2020 American Transplant Congress

    Impact of Variation in Histological Assessments and Their Impact on Clinical Trial Enrollment and Endpoints – Preliminary Report of The Gen04 Study

    W. Park1, M. Ryan2, L. Herrera Hernandez3, M. Smith2, X. Geiger4, T. Sandor5, L. Cornell3, M. Stegall1

    1Transplant Center, Mayo Clinic, Rochester, MN, 2Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, 3Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 4Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, 5Pathology, University of Szegad, Szegad, Hungary

    *Purpose: Renal allograft histology is often used as inclusion criteria for clinical trials. This includes Gen04, which is an NIH sponsored multi-center clinical trial involving…
  • 2020 American Transplant Congress

    Cost-Effectiveness of Protocol Biopsies in Kidney Transplantation

    C. M. Puttarajappa, S. Hariharan, K. J. Smith

    Medicine, University of Pittsburgh, Pittsburgh, PA

    *Purpose: To perform an economic evaluation of protocol biopsies in kidney transplantation*Methods: We used a Markov decision analytical model (Figure 1) to compare the following…
  • 2020 American Transplant Congress

    The Impact of DSA Screening in Stable Kidney Transplant Recipients in the 1st Year Post-Transplant

    A. Sharma1, D. Jorgensen2, R. Mehta1, P. Sood1, C. Wu1, C. M. Puttarajappa1, A. Tevar1, S. Hariharan1

    1Thomas E. Starzl Transplant Institute, Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The importance of Donor Specific Antibody (DSA) as a screening tool within the 1st year post kidney transplant in stable patients remains unclear. We…
  • 2020 American Transplant Congress

    Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation

    S. Raza, G. Agarwal, D. Anderson, M. Deierhoi, H. Fatima, M. Hanaway, J. Locke, P. MacLennan, B. Orandi, C. Young, R. Mannon, M. Seifert

    University of Alabama School of Medicine, Birmingham, AL

    *Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…
  • 2020 American Transplant Congress

    Torque Teno Virus Level for Risk Stratification of Subclinical Graft Rejection at 12 Months after Kidney Transplantation – An Prospective Observational Cohort Study

    K. Doberer, E. Puchhammer, G. Böhmig, G. Bond

    Medical University Vienna, Vienna, Austria

    *Purpose: Non-invasive monitoring strategies are insufficient to detect patients at risk for subclinical graft rejection after kidney transplantation. The highly prevalent and non-pathogenic Torque Teno…
  • 2020 American Transplant Congress

    Impact of Focal Cortical Necrosis (CN) in Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation

    S. S. Nair, J. Ninan, R. Heilman, K. Reddy, M. Smith

    Mayo Clinic, Phoenix, AZ

    *Purpose: The data on outcomes of focal CN in PBx after deceased donor transplantation is sparse. We studied the prognostic value of focal CN on…
  • 2020 American Transplant Congress

    1 -Year Protocol Biopsies in Pediatric Kidney Transplant Children: Are Unfavorable Histological Lesions Related to No Adherence?

    M. L. Monteverde1, J. M. Velasco1, V. Solernou2, J. P. Ibanez1, C. Cernadas3, A. B. Chaparro4, Y. L. Marcos5

    1Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 2Pathology, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 3Teaching and Investigation, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 4Nephrology, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 5Hemoteraphy, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina

    *Purpose: In adults with kidney transplantation (KT), histological findings in surveillance biopsies at 1-year post KT are independent correlate to short and long-term graft survival.…
  • 2020 American Transplant Congress

    The 1st Year Posttransplant Course Reliably Predicts Kidney Graft Survival up to 15 Years Using a Machine Learning-Based Modeling Approach

    W. Gwinner, M. Gietzelt, R. Hanna, A. A. Khalifa, M. Hallensleben, M. Marschollek, H. Haller, J. H. Braesen, I. Scheffner

    Hannover Medical School, Hannover, Germany

    *Purpose: Identification of patients at risk for graft failure can improve individual surveillance and early therapeutic interventions. We used a well-documented patient cohort to establish…
  • 2020 American Transplant Congress

    The UCSF Cardiovascular Risk after Kidney Transplantation (CARAKTER) Study

    M. Park1, Y. Gao1, S. Schroeder2, S. Siyahian1, Z. Laszik1, F. Vincenti1

    1UCSF, San Francisco, CA, 2UC Davis, Sacramento, CA

    *Purpose: We established the UCSF CARAKTER (Cardiovascular Risk After Kidney Transplantation) Study in order to evaluate risk factors for cardiac disease onset and progression in…
  • 2020 American Transplant Congress

    Impact of Timing of T Cell Mediated Rejection in the First Year after Kidney Transplantation

    R. Mehta, D. Jorgensen, C. Puttarajappa, S. Hariharan, R. Mehta, P. Sood

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: To evaluate the impact of timing of T-cell mediated rejection (TCMR) occurrence in the first year after kidney transplantation (KT).*Methods: Single center retrospective cohort…
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