2016 American Transplant Congress
Effect of Isolated Intraperitoneal Sirolimus Treatment on the Kidneys of C57BL/6 Mice.
Sirolimus, a mammalian target of rapamycin inhibitor, is widely used in transplantation. However, the mechanism by which sirolimus induces adverse effects such as proteinuria and…2015 American Transplant Congress
Early Conversion to Everolimus in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study
For the ELEVATE Study, Leiden, Netherlands.
Purpose: Long-term exposure to calcineurin inhibitors (CNIs) contributes to unfavorable long-term outcomes, including inferior renal function and premature graft loss with vascular lesions, glomerulosclerosis and…2015 American Transplant Congress
Belatacept Based Immunosuppression and Incidence of Proteinuria in Kidney Transplant Recipients
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Abatacept which is a co-stimulation inhibitor has been suggested to have B7-1 mediated antiproteinuric effects. Belatacept which is another co-stimulation agent has been approved…2015 American Transplant Congress
Utility of Anti-Phospholipase A2 Receptor (Anti-PLA2R) ELISA Testing in Predicting Post-Transplant Idiopathic Membranous Nephropathy (IMN)
Backgound: IMN is frequently associated with autoantibodies to the podocyte antigen, PLA2R. Anti-PLA2R associated IMN is diagnosed by detecting PLA2R antigen within glomerular immune complexes…2015 American Transplant Congress
Serum Uric Acid Is Associated With Hypertension in Kidney Donors
Introduction:Uric acid has been linked to the development of hypertension and possibly CKD. Moreover, some preliminary data suggests that lowering uric acid maybe associated with…2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…2015 American Transplant Congress
Proteinuria as Non-Invasive Marker for Renal Allograft Histology and Survival: A Population-Based Study
University Hospitals Leuven, Leuven, Belgium.
Background:Proteinuria is routinely measured for assessment of renal allograft status, but its diagnostic value for transplant pathology and herewith-related prognostic value remain unclear.Methods:We included 1518…2015 American Transplant Congress
Absence of Low-Grade Proteinuria Is Associated With Improved Outcomes in Patients With Worse 3 Month Graft Function in Renal Transplantation
1Leeds Teaching Hospitals, Leeds, United Kingdom; 2University of Pittsburgh, Pittsburgh.
Low-grade proteinuria has been shown to be associated with adverse outcomes after renal transplantation. However most patients with proteinuria have worse eGFR and this interaction…2015 American Transplant Congress
Birth Weight as a Marker of Nephron Mass: Predicting Living Kidney Donor Outcomes
It has been demonstrated that low birth weights give rise to a reduction in nephron number and low glomerular size in the postnatal kidney. Oligonephropathy…2015 American Transplant Congress
Excellent Outcomes of Prophylactic Rituximab Administration With Plasmapheresis in Kidney Transplant Recipients With Focal Segmental Glomerulosclerosis
[Background]The estimated recurrence rate of focal segmental glomerulosclerosis (FSGS) after kidney transplantation is approximately 30%. Relapse occurring immediately after transplantation is refractory to treatment and…
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