Articles tagged "Proteinuria"

2016 American Transplant Congress
Impact of Early Calcineurin Inhibitor Withdrawal on Renal Function and Urinary Protein Excretion: 24 Month Analyses of the ELEVATE Study.
J. de Fijter,¹ H. Holdaas,¹ M. Seelen,¹ S. Sundar,¹ F. Bemelman,¹ P. Lopez,² J. Aguilar,² P. Bernhardt,² Z. Wang,³ J. Cruzado,¹ M. van der Giet.¹
¹ELEVATE study group, Leiden, Netherlands; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover, NJ.
Background: Proteinuria is a biomarker which helps in predicting graft outcomes in kidney transplant recipients (KTxRs). The ELEVATE study was designed to determine whether an…
2015 American Transplant Congress
Birth Weight as a Marker of Nephron Mass: Predicting Living Kidney Donor Outcomes
T. Schachtner,^1,2 P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
It has been demonstrated that low birth weights give rise to a reduction in nephron number and low glomerular size in the postnatal kidney. Oligonephropathy…
2015 American Transplant Congress
Early Conversion to Everolimus in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study
J. de Fijter, H. Holdaas, A. Speziale, G. Junge, Z. Wang, J. Cruzado, M. van der Giet.
For the ELEVATE Study, Leiden, Netherlands.
Purpose: Long-term exposure to calcineurin inhibitors (CNIs) contributes to unfavorable long-term outcomes, including inferior renal function and premature graft loss with vascular lesions, glomerulosclerosis and…
2015 American Transplant Congress
Belatacept Based Immunosuppression and Incidence of Proteinuria in Kidney Transplant Recipients
R. Villicana, A. Peng, J. Kahwaji, J. Choi, A. Vo, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Abatacept which is a co-stimulation inhibitor has been suggested to have B7-1 mediated antiproteinuric effects. Belatacept which is another co-stimulation agent has been approved…
2015 American Transplant Congress
Utility of Anti-Phospholipase A2 Receptor (Anti-PLA2R) ELISA Testing in Predicting Post-Transplant Idiopathic Membranous Nephropathy (IMN)
C. VanBeek,¹ D. Thomas,² A. Jimenez,² A. Vo,² S. Jordan,² M. Toyoda.²
¹Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ²Transplant Immunology, Cedars-Sinai Medical Center, Los Angeles, CA.
Backgound: IMN is frequently associated with autoantibodies to the podocyte antigen, PLA2R. Anti-PLA2R associated IMN is diagnosed by detecting PLA2R antigen within glomerular immune complexes…
2015 American Transplant Congress
Excellent Outcomes of Prophylactic Rituximab Administration With Plasmapheresis in Kidney Transplant Recipients With Focal Segmental Glomerulosclerosis
M. Okumi,¹ Y. Miyauchi,² T. Yagisawa,¹ K. Unagami,¹ D. Toki,¹ K. Omoto,¹ H. Ishida,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ²Urology, Ehime University, Matsuyama, Ehime, Japan.
[Background]The estimated recurrence rate of focal segmental glomerulosclerosis (FSGS) after kidney transplantation is approximately 30%. Relapse occurring immediately after transplantation is refractory to treatment and…
2015 American Transplant Congress
Serum Uric Acid Is Associated With Hypertension in Kidney Donors
S. Reule,¹ R. Foley,¹ A. Matas,² H. Ibrahim.¹
¹Department of Medicine, University of Minnesota, Minneapolis, MN; ²Department of Surgery, University of Minnesota, Minneapolis, MN.
Introduction:Uric acid has been linked to the development of hypertension and possibly CKD. Moreover, some preliminary data suggests that lowering uric acid maybe associated with…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…
2015 American Transplant Congress
Proteinuria as Non-Invasive Marker for Renal Allograft Histology and Survival: A Population-Based Study
M. Naesens, E. Lerut, M.-P. Emonds, D. Kuypers.
University Hospitals Leuven, Leuven, Belgium.
Background:Proteinuria is routinely measured for assessment of renal allograft status, but its diagnostic value for transplant pathology and herewith-related prognostic value remain unclear.Methods:We included 1518…
2015 American Transplant Congress
Absence of Low-Grade Proteinuria Is Associated With Improved Outcomes in Patients With Worse 3 Month Graft Function in Renal Transplantation
A. Seitz,¹ A. Cherukuri,² R. Baker.¹
¹Leeds Teaching Hospitals, Leeds, United Kingdom; ²University of Pittsburgh, Pittsburgh.
Low-grade proteinuria has been shown to be associated with adverse outcomes after renal transplantation. However most patients with proteinuria have worse eGFR and this interaction…