2018 American Transplant Congress
Antiproteinuric Effect of Spironolactone in Renal Transplantation: Effectiveness and Clinical Outcomes
University of Campinas, Campinas, Sao Paulo, Brazil.
Background: aldosterone is involved in development of fibrosis in kidney transplantation. Blockade of aldosterone receptor appears to be effective in treatment for chronic allograft dysfunction,…2017 American Transplant Congress
Renal Function, Albuminuria, and the Risk of Death and Graft Loss After Kidney Transplantation.
In 2012, the KDIGO guidelines updated the classification system for chronic kidney disease to include albuminuria. Whether this classification system prognosticates adverse clinical outcomes among…2017 American Transplant Congress
Renal Function Outcomes by HLA Mismatch in De Novo Kidney Transplant Recipients Receiving Everolimus PlusReduced-Dose Cyclosporine versus Mycophenolate Plus Standard-Dose Cyclosporine: 24-Month Subanalysis of A1202 Study.
Purpose: High levels of human leukocyte antigen (HLA) mismatches are a key determinant of kidney allograft survival. Here, we present 24-month (M) subanalysis of the…2017 American Transplant Congress
Determinants of Successful Use of Sirolimus in Renal Transplantation.
Sirolimus (SLR) is an established component in the immunosuppressive treatment after renal transplantation.The side effects of SLR differ from other immunosuppressants and may limit its…2017 American Transplant Congress
Early Introduction of Oral Paricalcitol in Renal Transplant Recipients. An Open-Label Randomized Study.
In stable renal transplant recipients with hyperparathyroidism, the vitamin D agonist paricalcitol reduces level of proteinuria. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. The…2017 American Transplant Congress
Interruption of RAAS in Hypertensive Proteinuric Kidney Donors.
The aim of this analysis was to assess the progression of eGFR between proteinuric hypertensive living kidney donors (HTN-LKDs) receiving ACE inhibitors (ACEinh) or angiotensin…2017 American Transplant Congress
Podocyte-Specific Knockdown of SHROOM3 Causes Albuminuria and Foot-Process Effacement by Interaction with FYN.
Nephrology, Medicine, Icahn School of Medicine, New York, NY
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular SHROOM3 expression correlated with the development of renal fibrosis post-transplant. The SNP…2017 American Transplant Congress
RAS Inhibition Attenuates Urine Angiotensin II-Regulated Proteins Associated with Interstitial Fibrosis and Tubular Atrophy in Kidney Transplant Recipients.
Angiotensin-II (AngII), the main effector of the renin-angiotensin system (RAS), can lead to interstitial fibrosis/ tubular atrophy (IFTA) in kidney transplant recipients, mainly through AT-1R…2017 American Transplant Congress
Acthar in Recurrent Focal Segmental Glomerular Sclerosis After Kidney Transplantation.
1Washington University in St. Louis, St. Louis; 2Johns Hopkins University, Baltimore
Treatment of Recurrent focal segmental glomerular sclerosis (FSGS) after kidney transplantation is challenging with unpredictable outcomes. Conventional therapeutic options include various combinations of plasmapheresis, steroids,…2017 American Transplant Congress
Treatment of Post-Transplant Nephrotic Syndrome with Adrenocorticotropic (ACTH) Gel.
1Medstar Georgetown Transplant Institute, Washington DC; 2Indiana University Health, Indianapolis
Objectives: Post-kidney transplant proteinuria due to recurrent GN is considered to be a significant risk factor negatively affecting kidney transplant survival. In this case series…
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