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Articles tagged "Proteinuria"

  • 2019 American Transplant Congress

    Assessment of Proteinuria Reported as Adverse Events in De Novo Renal Transplant Recipients Receiving an Everolimus-Based Regimen: 24-Month Results from TRANSFORM

    C. Legendre1, S. Berger1, F. Oppenheimer1, A. Wiseman1, S. Steinberg1, O. Viklicky1, G. Russ1, R. Danguilan1, N. Basic-Jukic1, E. Mor1, P. Narvekar2, M. P. Hernandez Gutierrez2, P. Bernhardt2, C. Sommerer1

    1TRANSFORM Study Group, Basel, Switzerland, 2Novartis Pharma AG, Basel, Switzerland

    *Purpose: mTOR inhibitors (eg, everolimus [EVR]), are thought to increase the risk of post-transplant (Tx) proteinuria (PU). Here, we assess PU onset and outcomes in…
  • 2019 American Transplant Congress

    Monitoring And Management Of Proteinuria Is Often Ignored In Patients Receiving mTOR Therapy Following Orthotopic Liver Transplantation

    R. Kaur1, O. Sadiq2, M. Alimirah1, F. Kumssa1, A. Patel3, S. Jafri2

    1Internal Medicine, Henry Ford Hospital, Detroit, MI, 2Gastroenterology, Henry Ford Hospital, Detroit, MI, 3Nephrology, Henry Ford Hospital, Detroit, MI

    *Purpose: Use of mTOR inhibitors, such as Everolimus (EVL), in liver transplant (LT) patients continues to rise as the side effect profile becomes more evident.…
  • 2019 American Transplant Congress

    Urinary Podocin mRNA as Predictor of Renal Allograft Function Decline

    A. Naik1, J. Aqeel1, D. Cibrik2, M. Samaniego3, L. Wickman1, S. Wang1, M. Chowdhury1, R. Wiggins1

    1University of Michigan, Ann Arbor, MI, 2University of Kansas, Kansas City, KS, 3Henry Ford, Detroit, MI

    *Purpose: Traditional biomarkers (such as proteinuria, 1year eGFR) as well as validated risk prediction tools such as the Birmingham Risk Score predict risk of ESRD.…
  • 2019 American Transplant Congress

    The Implications of Donor Proteinuria in Deceased Donor Kidney Transplantation

    A. Vinson, T. Keough-Ryan, K. West, K. Tennankore

    Dalhousie University, Halifax, NS, Canada

    *Purpose: The implications of pre-terminal donor urinalysis findings on post-transplant kidney graft survival has not been previously explored. An abnormal donor urinalysis may reflect donor…
  • 2019 American Transplant Congress

    Impact Of Rituximab And Maintenance Steroid In The Recurrence Of Focal Segmental Glomerulosclerosis

    L. A. Mendez Castaner

    Transplant, Miami Transplant Institute-University of Miami, Miami, FL

    *Purpose: Recurrence of focal segmental glomerulosclerosis (FSGS) has been reported between 20-80% with up to 60% of graft loss. Rituximab has demonstrated to be effective…
  • 2019 American Transplant Congress

    Renal Pathological Findings in Living Kidney Donor Candidates with Minimal Urinary Abnormalities

    H. Ahmed1, C. Drachenberg2, R. Ugarte1, N. Costa1, C. Cangro1, R. N. Barth3, M. Weir1, A. Harirain1

    1Medicine-Nephrology, University of Maryland Medical Center, Baltimore, MD, 2Pathology, University of Maryland Medical Center, Baltimore, MD, 3Surgery, University of Maryland Medical Center, Baltimore, MD

    *Purpose: With the increasing number of ESRD patients requiring transplantation and stagnant number of deceased-donor organs available, minimizing the exclusion of living donor candidates with…
  • 2019 American Transplant Congress

    Use of Opioids and NSAIDs in Living Kidney Donors: Clinical Correlates and Early Outcomes

    K. Lentine1, L. Vest1, Z. Zhang1, F. Koraishy1, M. Schnitzler1, A. Garg2, D. Axelrod3, B. Kasiske4, G. Hess5, A. Naik6, D. Segev7, M. Henderson7, A. Massie7, N. Lamm8

    1Saint Louis Univ, St. Louis, MO, 2Western Univ, London, ON, Canada, 3Univ of Iowa, Iowa City, IA, 4SRTR, Minneapolis, MN, 5Univ of Pennsylvania, Philadelphia, PA, 6Univ of Michigan, Ann Arbor, MI, 7Johns Hopkins, Baltimore, MD, 8Univ Alberta, Edmonton, AB, Canada

    *Purpose: Data are limited regarding pain medication use in living kidney donors (LKD). Concerns relate to opioid use, and to non-steroidal anti-inflammatory (NSAID) use in…
  • 2019 American Transplant Congress

    An Interesting Case of Proteinuria in Living Kidney Donor

    A. Yadav, W. Maley, P. Singh

    Thomas Jefferson University, Philadelphia, PA

    *Purpose: Evaluation for proteinuria is vital to assess suitability for live kidney donation. Living unrelated donor with orthostatic proteinuria was evaluated. This case highlights importance…
  • 2019 American Transplant Congress

    Sex Specific Regulation of Podocyte-Specific Genes and Proteins Determines Glomerular Response to mTOR Inhibition

    A. Kusch1, O. AlDiab2, D. Gürgen2, C. Sünkel3, F. Grahammer4, M. Rinschen5, T. Huber4, N. Rajewsky3, D. Dragun2

    1Medizinische Klinik m. S. Nephrologie und Internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Medizinische Klinik m. S. Nephrologie und internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, 3Max-Delbrück Center for Molecular Medicine, Berlin, Germany, 4III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg - Eppendorf, Hamburg, Germany, 5CECAD Research Center, Universitätsklinikum Köln, Köln, Germany

    *Purpose: mTOR inhibitors are increasingly used in transplantation with high interindividual variation in proteinuric responses. Although males have higher prevalence and faster progression of glomerular…
  • 2018 American Transplant Congress

    High GFR in Kidney Donors is Associated with Increased Risk of Proteinuria and Diabetes

    D. Keys, S. Riad, V. Vakil, S. Jackson, D. Berglund, A. Matas.

    University of Minnesota, Minneapolis, MN.

    Background: Measured glomerular filtration rate (GFR) has been part of the donor evaluation to rule out low GFR donors from taking undue risk for ESRD.…
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