2019 American Transplant Congress
The Implications of Donor Proteinuria in Deceased Donor Kidney Transplantation
Dalhousie University, Halifax, NS, Canada
*Purpose: The implications of pre-terminal donor urinalysis findings on post-transplant kidney graft survival has not been previously explored. An abnormal donor urinalysis may reflect donor…2019 American Transplant Congress
Impact Of Rituximab And Maintenance Steroid In The Recurrence Of Focal Segmental Glomerulosclerosis
Transplant, Miami Transplant Institute-University of Miami, Miami, FL
*Purpose: Recurrence of focal segmental glomerulosclerosis (FSGS) has been reported between 20-80% with up to 60% of graft loss. Rituximab has demonstrated to be effective…2019 American Transplant Congress
Renal Pathological Findings in Living Kidney Donor Candidates with Minimal Urinary Abnormalities
*Purpose: With the increasing number of ESRD patients requiring transplantation and stagnant number of deceased-donor organs available, minimizing the exclusion of living donor candidates with…2019 American Transplant Congress
Use of Opioids and NSAIDs in Living Kidney Donors: Clinical Correlates and Early Outcomes
*Purpose: Data are limited regarding pain medication use in living kidney donors (LKD). Concerns relate to opioid use, and to non-steroidal anti-inflammatory (NSAID) use in…2019 American Transplant Congress
An Interesting Case of Proteinuria in Living Kidney Donor
Thomas Jefferson University, Philadelphia, PA
*Purpose: Evaluation for proteinuria is vital to assess suitability for live kidney donation. Living unrelated donor with orthostatic proteinuria was evaluated. This case highlights importance…2019 American Transplant Congress
Sex Specific Regulation of Podocyte-Specific Genes and Proteins Determines Glomerular Response to mTOR Inhibition
*Purpose: mTOR inhibitors are increasingly used in transplantation with high interindividual variation in proteinuric responses. Although males have higher prevalence and faster progression of glomerular…2019 American Transplant Congress
Shroom3 Regulates Glomerular Hypertrophy after Uninephrectomy via mTOR
Mount Sinai School of Medicine, New York, NY
*Purpose: A Shroom3 intronic risk locus & Shroom3 protein have been associated with increased fibrosis but reduced albuminuria in recipients of allografts with the risk…2019 American Transplant Congress
Significance of Histopathologic Features for Predicting Progression in Patients with Transplant Glomerulopathy
National Clinical Research Center of Kidney Diseases, Nanjing, China
*Purpose: Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. We aimed to determine…2019 American Transplant Congress
Assessment of Proteinuria Reported as Adverse Events in De Novo Renal Transplant Recipients Receiving an Everolimus-Based Regimen: 24-Month Results from TRANSFORM
1TRANSFORM Study Group, Basel, Switzerland, 2Novartis Pharma AG, Basel, Switzerland
*Purpose: mTOR inhibitors (eg, everolimus [EVR]), are thought to increase the risk of post-transplant (Tx) proteinuria (PU). Here, we assess PU onset and outcomes in…2018 American Transplant Congress
Everolimus with Reduced-Dose Calcineurin Inhibitor versus Mycophenolate with Standard-Dose Calcineurin Inhibitor in De Novo Kidney Transplant Recipients: Renal Function Results from the TRANSFORM Study
1TRANSFORM Study Group, Barcelona, Spain; 2Novartis Pharma AG, Basel, Switzerland.
Purpose: TRANSFORM (NCT01950819) is the largest study conducted in de novo kidney transplant recipients (KTxRs) to evaluate the benefit of everolimus with reduced-dose calcineurin inhibitor…
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