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Articles tagged "Prophylaxis"

  • 2019 American Transplant Congress

    Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients

    J. L. Orejas1, F. M. Marty1, A. M. McDonnell2, M. P. Cheng1, E. Arbona-Haddad1, S. P. Hammond1, S. Koo1

    1Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, 2Department of Pharmacy, Brigham and Women's Hospital, Boston, MA

    *Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
  • 2019 American Transplant Congress

    Incidence of Cytomegalovirus in Moderate Risk Kidney Transplant Recipients Receiving Low Dose Valganciclovir

    T. Fallah1, A. Logan2, L. Beltran Garcia3, L. Bowman2

    1Hospital of the University of Pennsylvania, Philadelphia, PA, 2Tampa General Hospital, Tampa, FL, 3Florida Kidney Physicians, Tampa General Hospital, Tampa, FL

    *Purpose: Studies evaluating the efficacy of valganciclovir (VGC) at 450 mg daily versus 900 mg daily for the prevention of cytomegalovirus (CMV) in kidney transplant…
  • 2019 American Transplant Congress

    Target Itraconazole Trough Concentration for Prophylaxis in Lung Transplant

    J. A. Morillas-Rodriguez1, H. Hassouna2, F. Marco-Canosa3, K. D. Brizendine1

    1Infectious disease, Cleveland Clinic, Cleveland, OH, 2Infectious disease, Spectrum health, Grand rapids, MI, 3Cleveland Clinic, Cleveland, OH

    *Purpose: Itraconazole (ITR) therapeutic drug monitoring (TDM) for prophylaxis in lung transplant recipients (LTR) is not well characterized. Our purpose was to evaluate ITR trough…
  • 2019 American Transplant Congress

    Outbreak of Pneumocystis Pneumonia in a Transplant Center Linked to a Single Genotype of Pneumocystis jirovecii: Effects of Cytomegalovirus Infection and Allograft Rejection

    S. Hosseini-Moghaddam1, S. Dufresne2, M. Shokoohi3, G. Singh1, E. HunterGutierrez1, P. Dufresne2, A. House1, P. Luke1, A. Nagpal1, P. Marotta1, A. Humar4, A. Jevnikar1, D. Kumar4

    1Western University,LHSC,University Hospital, London, ON, Canada, 2Maisonneuve-Rosemont Hospital,Université de Montréal, Montreal, QC, Canada, 3Epidemiology and Biostatistics, Western University, London, ON, Canada, 4University of Toronto, University Health Network, Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Although post-transplant pneumocystis pneumonia (PCP) outbreaks have been reported from Asia, Australia and Europe, there are limited data from North America. We investigated transmissibility…
  • 2018 American Transplant Congress

    Itraconazole Prophylaxis, Trough Concentration, and Identification of Fungal Pathogens in Lung Transplant

    H. Hassouna, V. Athans, K. Brizendine.

    Cleveland Clinic Foundation, Cleveland, OH.

    Studies of prophylactic itraconazole (ITR) in lung transplant recipients (LTR) are lacking. Our purpose was to evaluate LTR who received ITR prophylaxis and the association…
  • 2018 American Transplant Congress

    Incidence of Atrial Arrhythmia after Lung Transplantation with a Universal Prophylaxis Strategy

    M. Sullivan,1 J. Lin,2 R. Bag,2 L. Potter.1

    1Department of Pharmacy, The University of Chicago Medicine, Chicago, IL; 2Medicine/Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL.

    PurposePostoperative atrial arrhythmias (AA) occur in 19-39% of patients after lung transplantation and are associated with increased mortality, hospital length of stay, and risk of…
  • 2018 American Transplant Congress

    Evaluation of a Change in CMV Prevention Strategy Following Pediatric SOT

    S. Pangonis, A. Miethke, F. Flores, M. Schecter, S. Kocoshis, D. Lazear, T. Hemmelgam, B. Taylor, G. Paulsen, L. Danziger-Isakov.

    Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    Optimal cytomegalovirus(CMV) prevention strategy following solid organ transplantation(SOT) is uncertain. We report on CMV disease with implementation of prophylaxis-based prevention with intensive monitoring.We retrospectively evaluated…
  • 2018 American Transplant Congress

    Efficacy of Two Valganciclovir Dosing Strategies in Intermediate and High-Risk Liver Transplant Recipients

    K. Belfield,1 M. Malinis,2 E. Cohen.1

    1Department of Pharmacy, Yale New Haven Hospital, New Haven, CT; 2Section of Infectious Diseases, Yale School of Medicine, New Haven, CT.

    Purpose: There is interest in reduced dosing and duration of valganciclovir (VGCV) for cytomegalovirus (CMV) prophylaxis in liver transplant (LT) recipients to minimize side effects…
  • 2018 American Transplant Congress

    Impact of Positive Donor Blood Cultures in Liver Transplant Recipients

    D. Bley, D. Lo, G. Lyon III, R. Subramanian, S. Todd.

    Emory University Hospital, Atlanta, GA.

    The purpose of this study was to describe the bacteremia transmission rate of transplanting livers from donors with positive bacterial blood cultures into liver transplant…
  • 2018 American Transplant Congress

    Early versus Late Cytomegalovirus Prophylaxis after Kidney Transplant

    M. Harris, J. Byrns, J. Gommer, M. Laub, M. Ellis.

    Duke University Hospital, Durham, NC.

    Background: Prophylaxis against cytomegalovirus (CMV) is recommended in high-risk patients (CMV D+/R-) and those who are CMVR+ and getting T-cell depletional therapy. It is unclear…
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