Articles tagged "Prophylaxis"

2019 American Transplant Congress
Use of a CMV Specific T Cell Immunity Assay in Late-Onset CMV Infection
O. Beaird¹, M. Carlson¹, P. Gaynor¹, D. Nanayakkara¹, B. Abdalla², S. Bunnapradist², J. Schaenman¹
¹Department of Internal Medicine - Division Infectious Diseases, UCLA, Los Angeles, CA, ²Department of Internal Medicine - Division Nephrology, UCLA, Los Angeles, CA
*Purpose: To describe our clinical experience using a CMV Specific Cell Mediated Immunity (CMI) assay in solid organ transplant (SOT) recipients with late-onset CMV, defined…
2019 American Transplant Congress
Retrospective Evaluation of Optimal Cmv Prophylaxis Regimens in Lung Transplant Patients: Analysis of Patient Outcomes Pre and Post Protocol Dosing Alterations
J. Hunt, A. Nasar, R. Walia, L. Cherrier
St. Joseph Hospital and Medical Center, Phoenix, AZ
*Purpose: Given the heightened risk of cytomegalovirus (CMV) following lung transplantation compared to other solid organ transplants, with minimal evidence based guidance specific to this…
2019 American Transplant Congress
Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients
J. L. Orejas¹, F. M. Marty¹, A. M. McDonnell², M. P. Cheng¹, E. Arbona-Haddad¹, S. P. Hammond¹, S. Koo¹
¹Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, ²Department of Pharmacy, Brigham and Women's Hospital, Boston, MA
*Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
2019 American Transplant Congress
Incidence of Cytomegalovirus in Moderate Risk Kidney Transplant Recipients Receiving Low Dose Valganciclovir
T. Fallah¹, A. Logan², L. Beltran Garcia³, L. Bowman²
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Tampa General Hospital, Tampa, FL, ³Florida Kidney Physicians, Tampa General Hospital, Tampa, FL
*Purpose: Studies evaluating the efficacy of valganciclovir (VGC) at 450 mg daily versus 900 mg daily for the prevention of cytomegalovirus (CMV) in kidney transplant…
2019 American Transplant Congress
Target Itraconazole Trough Concentration for Prophylaxis in Lung Transplant
J. A. Morillas-Rodriguez¹, H. Hassouna², F. Marco-Canosa³, K. D. Brizendine¹
¹Infectious disease, Cleveland Clinic, Cleveland, OH, ²Infectious disease, Spectrum health, Grand rapids, MI, ³Cleveland Clinic, Cleveland, OH
*Purpose: Itraconazole (ITR) therapeutic drug monitoring (TDM) for prophylaxis in lung transplant recipients (LTR) is not well characterized. Our purpose was to evaluate ITR trough…
2019 American Transplant Congress
Outbreak of Pneumocystis Pneumonia in a Transplant Center Linked to a Single Genotype of Pneumocystis jirovecii: Effects of Cytomegalovirus Infection and Allograft Rejection
S. Hosseini-Moghaddam¹, S. Dufresne², M. Shokoohi³, G. Singh¹, E. HunterGutierrez¹, P. Dufresne², A. House¹, P. Luke¹, A. Nagpal¹, P. Marotta¹, A. Humar⁴, A. Jevnikar¹, D. Kumar⁴
¹Western University,LHSC,University Hospital, London, ON, Canada, ²Maisonneuve-Rosemont Hospital,Université de Montréal, Montreal, QC, Canada, ³Epidemiology and Biostatistics, Western University, London, ON, Canada, ⁴University of Toronto, University Health Network, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Although post-transplant pneumocystis pneumonia (PCP) outbreaks have been reported from Asia, Australia and Europe, there are limited data from North America. We investigated transmissibility…
2019 American Transplant Congress
Pneumocystis Prophylaxis in Solid Organ Transplant Recipients at Two Large Transplant Centers from 2015-2016: Why Not Trimethoprim-Sulfamethoxazole?
J. M. Lum¹, V. Athans², I. Echenique³, C. E. Koval¹
¹Infectious Diseases, Cleveland Clinic Floundation, Cleveland, OH, ²Infectious Diseases, University of Pennsylvania, Philadelphia, PA, ³Infectious Diseases, Cleveland Clinic Florida, Weston, FL
*Purpose: Trimethoprim-sulfamethoxazole (T/S) is the drug of choice for Pneumocystis jirovecii pneumonia (PJP) prophylaxis (ppx) after solid organ transplant (SOT). Perceived side effects may lead…
2019 American Transplant Congress
Impact of a Short Duration, Narrow Spectrum Perioperative Antibiotic Prophylaxis Regimen on Multi-Drug Resistant Surgical Site Infections in Adult Orthotopic Liver Transplantation
M. John¹, K. Maguigan¹, D. Schain², E. Thomas³, P. Efron⁴, J. Nelson⁵
¹Pharmacy, UF Health Shands Hospital, Gainesville, FL, ²Infectious Diseases, UF Health Shands Hospital, Gainesville, FL, ³Transplant Surgery, University Health System, San Antonio, TX, ⁴Surgery, UF Health Shands Hospital, Gainesville, FL, ⁵Pharmacy, University Health System, San Antonio, TX
*Purpose: There is a paucity of data defining the optimal agent and timing of peri-operative antimicrobial prophylaxis in orthotopic liver transplantation (OLT). The purpose of…
2019 American Transplant Congress
Retrospective Evaluation of Dapsone Prophylaxis Complications in Kidney Transplant Recipients
S. Hamel¹, V. Johnson², D. Johnson², E. Blumberg³, R. Bloom⁴, J. Trofe-Clark²
¹Pharmacy, Vanderbilt Univ. Medical Center, Nashville, TN, ²Pharmacy, Hospital of the Univ. of Pennsylvania, Philadelphia, PA, ³Infectious Diseases, Univ. of Pennsylvania, Philadelphia, PA, ⁴Renal, Univ. of Pennsylvania, Philadelphia, PA
*Purpose: Secondary options for Pneumocystis Jirovecii pneumonia (PJP) prophylaxis in kidney transplant recipients (KTRs) include atovaquone or dapsone. Atovaquone use may be limited by cost/side…
2019 American Transplant Congress
Low-Dose Valacyclovir Prophylaxis for Cytomegalovirus Infection in Renal Transplant Recipients with Intermediate Risk
A. Velioglu¹, H. Arikan¹, E. Asicioglu¹, S. Alagoz², N. Seyahi², S. Tuglular¹, C. Ozener¹
¹Nephrology, Marmara University School of Medicine, İstanbul, Turkey, ²Nephrology, Istanbul University, Cerrahpasa Medical School, İstanbul, Turkey
*Purpose: According to recent guidelines ganciclovir or valganciclovir chemoprophylaxis is recommended for all kidney transplantation (KT) recipients (except for D-/R- serology) for preventing cytomegalovirus (CMV)…

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