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Articles tagged "Prophylaxis"

  • 2022 American Transplant Congress

    Preemptive  Therapy for Cytomegalovirus (CMV) Disease Prevention in High-Risk CMV Donor Seropositive Recipient Seronegative (D+/R-) Liver Transplant Recipients in a Real-World Setting 

    K. M. Doss1, C. Kling1, M. R. Heldman1, N. Singh2, M. Wagener3, C. E. Fisher1, A. Limaye1

    1University of Washington, Seattle, WA, 2University of Pittsburgh, PIttsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose:  Preemptive therapy  (PET)  has  demonstrated superiority to antiviral prophylaxis  for  prevention of  cytomegalovirus (CMV)  disease  in  CMV  donor seropositive/recipient seronegative (D+R-)  liver transplant recipients …
  • 2022 American Transplant Congress

    Comparison of Cephalexin and Ciprofloxacin Prophylaxis for Urinary Tract Infection in Kidney Transplant Recipients

    N. A. Pauley, M. Fitzmaurice, A. Poparad-Stezar, B. Summers, A. Jantz

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    *Purpose: Compare efficacy and safety outcomes of patients (pts) that received alternative agents as prophylaxis (ppx) for urinary tract infection (UTI) after kidney transplant (KT)…
  • 2022 American Transplant Congress

    Early versus Delayed Cytomegalovirus Prophylaxis in High-Risk Kidney Transplant Recipients

    A. Hutchins1, M. Leick2, M. Keck2, J. S. McMullen2

    1Pharmacy, Houston Methodist Hospital, Houston, TX, 2Pharmacy, Nebraska Medicine, Omaha, NE

    *Purpose: The purpose of this study is to determine the effect of delaying cytomegalovirus (CMV) prophylaxis to day of discharge or post-operative day (POD) 7…
  • 2022 American Transplant Congress

    Donor-Derived Carbapenem-Resistant Gram-Negative Infections: Risk Mitigation Strategy in Solid Organ Transplant Improves Recipients Safety and Could Expand Donor Pool

    A. Mularoni1, E. Graziano1, M. Campanella1, A. Cervo2, M. Peghin3, F. Barbera1, P. Conaldi1, A. Luca1, P. A. Grossi4

    1ISMETT, Palermo, Italy, 2Department of Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico of Modena, Modena, Italy, 3Division of Infectious Diseases, ASUFC, Udine, Italy, 4Infectious and Tropical Diseases Unit, University of Insubria, Varese, Italy

    *Purpose: We implemented an Active Surveillance System (ASS) to mitigate the risk of unexpected carbapenem-resistant Gram-negative (CRGN) donor-derived infection (DDI) in solid organ transplant recipient…
  • 2022 American Transplant Congress

    Comparison of Perioperative Antibiotic Prophylaxis Regimens on Surgical Site Infections in Pancreas Transplant Recipients

    Z. A. Yetmar1, M. McCord2, B. Lahr3, A. Lemke2, P. G. Dean4, Y. C. Kudva5, M. T. Seville6, W. Bosch7, S. A. Bernard2, E. Beam1

    1Division of Infectious Diseases, Mayo Clinic, Rochester, MN, 2Department of Pharmacy, Mayo Clinic, Rochester, MN, 3Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 4Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, 5Division of Endocrinology, Diabetes, Metabolism & Nutrition, Mayo Clinic, Rochester, MN, 6Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ, 7Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL

    *Purpose: Pancreas transplant recipients are at high risk of surgical site infection (SSI), with rates ranging from 9-45%. Several risk factors for SSI have been…
  • 2022 American Transplant Congress

    Therapeutic Drug Monitoring of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Patients

    S. Sial, K. Cunningham, J. Moore, C. Dagostino, K. Lang, C. Kane

    Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Lung transplant patients are at an increased risk for invasive fungal infections and often require prophylaxis post-transplant, routinely including posaconazole at our institution. These…
  • 2022 American Transplant Congress

    Assessment of Letermovir as Universal Prophylaxis for Cytomegalovirus Infection in Lung Transplant Recipients

    L. F. Borges, T. Sparkman, K. Gutierrez, J. Banbury

    UAB Hospital, Birmingham, AL

    *Purpose: Cytomegalovirus (CMV) poses a significant concern in the post-operative management of lung transplant (LT) recipients. Current recommended prophylactic strategies with ganciclovir (GCV) or valganciclovir…
  • 2021 American Transplant Congress

    Impact of a Cmv Cell Mediated Immunity Based Protocol on Guiding Cmv Prophylaxis Following Pediatric Liver Transplantation – A Single Center Experience

    G. Kalkan1, S. Ball2, L. McConnell2, D. M. Desai3, A. Aqul3, P. K. Sue1

    1Infectious Disease, University of Texas Southwestern Medical Center, Dallas, TX, 2Solid Organ Transplant Program, Children's Health, Dallas, TX, 3Solid Organ Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX

    *Purpose: Cytomegalovirus (CMV) is an important cause of morbidity following pediatric orthotopic liver transplantation (OLT), especially among high risk (HR) CMV D+/R- recipients. In 2019,…
  • 2021 American Transplant Congress

    Discontinuation of Trimethoprim/sulfamethoxazole Prophylaxis Due to Hyperkalemia in Kidney Transplant Recipients

    D. Pett1, G. Malat2, C. Domenico1, R. Samudralwar1, A. Forte1, D. Sawinski2, J. Hu1, B. Steiner1, J. Rashid1, J. Trofe-Clark2

    1Pharmacy, Hospital of Univ of Pennsylvania, Philadelphia, PA, 2Penn Transplant Institute, Hospital of Univ of Pennsylvania, Philadelphia, PA

    *Purpose: Trimethoprim-sulfamethoxazole (TMP-SMX) is the drug of choice for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in kidney transplant recipients (KTRs), however, it can be complicated by…
  • 2021 American Transplant Congress

    Evaluating Pneumocystis Jiroveci Pneumonia Prophylaxis in Lung Transplant Recipients

    J. Sharkey, K. McMurry, J. Park, C. Carlson, K. Gregg, D. Kaul, D. Lyu, L. Fitzgerald

    Michigan Medicine, Ann Arbor, MI

    *Purpose: The incidence of Pneumocystis jiroveci pneumonia (PJP) in lung transplant recipients (LTRs) on PJP prophylaxis is not well documented yet reported as high as…
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