Articles tagged "Prophylaxis"

2018 American Transplant Congress
Infection Outcomes in Solid Organ Transplant Recipients Receiving Trimethoprim-Sulfamethoxazole as Opposed to Atovaquone for Prophylaxis
A. Drelick,¹ W. Mowrey,² G. Minamoto.³
¹Medicine, Division of Infectious Diseases, Weill Cornell Medical Center, New York, NY; ²Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY; ³Medicine, Division of Infectious Diseases, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY.
Background: Pneumocystis jiroveci pneumonia (PJP) is an important illness amongst solid organ transplant (SOT) recipients. Trimethoprim-sulfamethoxazole (TMP-SMX) is the prophylaxis of choice based on efficacy…
2018 American Transplant Congress
Making Sense of Hepatitis B Reactivation Risk in Anti-HBc Antibody (Ab) Positive Liver Transplant Recipients
S. Leistman,¹ J. Melaragno,¹ M. Dokus,² B. Al-Judaibi,² T. Babu.³
¹Department of Pharmacy, University of Rochester Medical Center, Rochester, NY; ²Division of Transplantation, University of Rochester Medical Center, Rochester, NY; ³Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY.
Background: Limited data exists regarding the rates of reactivation of hepatitis B virus (HBV) in anti-HBc Ab positive orthotopic liver transplant (OLT) recipients. Protocols vary…
2018 American Transplant Congress
Val-Ganciclovir Prophylaxis Delays Onset of EBV Viremia in the First Year Post-Solid Organ Transplantation in High-Risk Patients
S. Albatati,¹ A. Sharma,² S. Gantt,¹ K. Haubrich,¹ A. Wright,¹ T. Blydt-Hansen.¹
¹University of British Columbia, Vancouver, Canada; ²University of Manitoba, Winnipeg, Canada.
Introduction: Donor-derived primary Epstein-Barr virus (EBV) infection poses serious risks to EBV naïve children post-solid organ transplantation, including development of EBV-related PTLD. Currently, there is…
2017 American Transplant Congress
Antibiotic Prophylaxis Against Urinary Tract Infections After Renal Transplant.
P. Klem,¹ J. Gralla,² D. Chang,¹ A. Wiseman,² S. Davis,² J. Cooper.²
¹Pharmacy, University of Colorado, Aurora, CO; ²Nephrology, University of Colorado, Aurora, CO
Urinary tract infections (UTI) are the most common infectious complication after kidney transplant. Previous research at our center showed sulfamethoxazole/trimethoprim (SMX/TMP) use for PCP prophylaxis…
2017 American Transplant Congress
Kidney Allocation Using CMV Matching Optimizes Low and High Risk Profiles for Prevention of CMV Infection in Kidney Transplant Recipients.
J. Lockridge,¹ E. Langewisch,² D. Basuli,¹ A. Olyaei,³ C. Shaut,⁴ D. Norman.¹
¹Division of Nephrology, Department of Medicine, Oregon Health and Science University, Portland, OR; ²Nephrology, University of Nebraska, Omaha, NE; ³Pharmacy, Oregon Health and Sciences University, Portland, OR; ⁴Immunogenetics and Transplant, Oregon Health and Sciences University, Portland, OR
Cytomegalovirus (CMV) confers a major impact on morbidity, mortality, and graft survival in kidney transplant recipients. Efforts to prevent CMV disease and infection have traditionally…
2017 American Transplant Congress
Low-Dose Valganciclovir for Cytomegalovirus Prophylaxis in Intermediate Risk Renal Transplants: A Single Center Experience.
A. Baghban,¹ K. Belfield,² M. Azar,¹ E. Cohen,² M. Malinis.¹
¹Infectious Diseases, Yale University, New Haven, CT; ²Pharmacy, YNHH, New Haven, CT
IntroductionCurrent guidelines on cytomegalovirus (CMV) prophylaxis following organ transplant recommend using valganciclovir (VGCV) 900 mg daily for high (CMV D+/R-) and intermediate (CMV R+) risk…
2017 American Transplant Congress
High-Dose Acyclovir for Cytomegalovirus Prevention in Seropositive Solid Organ Transplant Recipients.
J. Fose,¹ E. McCreary,¹ M. Jorgenson,¹ M. Lucey,² J. Smith.²
¹Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI; ²Medicine, University of Wisconsin Hospital and Clinics, Madison, WI
Purpose: Evaluate the incidence of cytomegalovirus (CMV) infection in seropositive (R+) solid organ transplant recipients (SOT) receiving high-dose acyclovir (HD-A, 800 mg QID) prophylaxis.Methods: Retrospective…
2017 American Transplant Congress
Vancomycin Prophylaxis for Prevention of Clostridium difficile Recurrence in Renal Transplant Patients.
L. Spliner,¹ J. Fose,¹ G. Leverson,² J. Smith,³ C. Saddler,³ M. Jorgenson.¹
¹Pharmacy, UW Health, Madison, WI; ²Surgery, UW Health, Madison, WI; ³Medicine, UW Health, Madison, WI
Purpose: Clostridium difficile infection (CDI) is higher in solid organ transplant recipients. IDSA/SHEA guidelines do not recommend prophylactic (PROPH) vancomycin (VANC) or metronidazole in CDI…
2017 American Transplant Congress
Efficacy of Trimethoprim-Sulfamethoxazole Prophylaxis for Nocardia in Solid Organ Transplant Recipients (SOTRs): Systematic Review and Meta-Analysis.
A. Alsharidi,¹ A. Gonzalez,² C. Rotstein,³ A. Humar,³ D. Kumar,³ S. Husain.³
¹Medicine, Infectious Diseases, McMaster University, Hamilton, ON, Canada; ²Medicine, Infectious Diseases, University of Florida, Gainesville, FL; ³Multi-Organ Transplant, Transplant Infectious Diseases, University of Toronto, Toronto, ON, Canada
Background:There are increasing reports of breakthrough Nocardia infection in patients taking Trimethoprim-Sulfamethoxazole (TMP-SMX) prophylaxis post SOT. We performed a meta-analysis to evaluate the effectiveness of…
2017 American Transplant Congress
Spousal Transmission of Hepatitis B from a Hepatitis B Core Antibody Positive Liver Transplant Recipient – A Case Report.
J. Gripshover, K. Hidalgo, B. Ravichandran.
University of Maryland Medical Center, Baltimore, MD
IntroductionGiven the shortage of donor organs, hepatitis B core antibody positive (HBcAb+) donors have been utilized to increase access to transplantation. It is well established…