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Articles tagged "Prophylaxis"

  • 2022 American Transplant Congress

    An Interventional Study Using Cell-Mediated Immunity to Guide Primary Prophylaxis for CMV Infection in Organ Transplant Recipients: A Multi-Center Study

    J. T. Solera1, C. Cervera2, S. Hosseini1, J. Gill3, S. Shalhoub4, J. Zaltzman5, N. Pinzon1, A. Humar1, D. Kumar1

    1UHN, Toronto, ON, Canada, 2UAlberta, Edmonton, AB, Canada, 3UBC, Vancouver, BC, Canada, 4LHSC, London, ON, Canada, 5StMH, Toronto, ON, Canada

    *Purpose: There are limited interventional studies using CMV cell-mediated immunity to guide the duration of antiviral prophylaxis. We aimed to use CMV CMI to guide…
  • 2022 American Transplant Congress

    Cmv-Specific Cell-Mediated Immune Reconstitution in High-Risk Hematopoietic Cell Transplant Recipients Receiving Letermovir Prophylaxis

    M. Z. Abidi1, K. Garth1, J. Gutman2, A. Weinberg1

    1Medicine, Infectious Disease, University of Colorado, Aurora, CO, 2Medicine, Hematology and Oncology, University of Colorado, Aurora, CO

    *Purpose: In the absence of antiviral prophylaxis following Hematopoietic Cell Transplant (HCT), the incidence of clinically significant cytomegalovirus reactivation (cCMV) is 30% in CMV seropositive…
  • 2022 American Transplant Congress

    Evaluation of Prophylactic Valganciclovir Dosing in Kidney Transplant Recipients at an Urban Transplant Institution

    E. Foster1, D. Pierce1, T. Cairns1, S. Borgetti2, I. Tzvetanov3, E. Benedetti3, C. Muran1

    1Pharmacy, University of Illinois at Chicago, Chicago, IL, 2Medicine, University of Illinois at Chicago, Chicago, IL, 3Surgery, University of Illinois at Chicago, Chicago, IL

    *Purpose: Dosing and duration of cytomegalovirus (CMV) prophylaxis with valganciclovir (VGC) in kidney transplant (KT) recipients is variable by transplant center. Prior studies have shown…
  • 2022 American Transplant Congress

    Incidence of Urinary Tract Infection or Asymptomatic Bacteriuria in Kidney Transplant Recipients with Sulfamethoxazole-Trimethoprim vs. Pentamidine for Pneumocystis Jiroveci Pneumonia Prophylaxis

    L. Selznick, H. Sweiss, C. Long, S. Bhayana, R. Hall

    University Health, San Antonio, TX

    *Purpose: To compare the incidence of urinary tract infection (UTI) or asymptomatic bacteriuria (ASB) post-kidney transplant (KT) with multiple Pneumocystis jiroveci pneumonia (PJP) prophylaxis regimens*Methods:…
  • 2022 American Transplant Congress

    Does a Second Transplant Increase the Risk for CMV Infection? An Evaluation of the Incidence of CMV Viremia in the Previously Transplanted Kidney Recipient

    J. Byrns1, G. Katz-Greenberg2

    1Pharmacy, Duke University Hospital, Durham, NC, 2Medicine, Duke University Medical Center, Durham, NC

    *Purpose: Cytomegalovirus (CMV) viremia is a common complication of kidney transplant recipients (KTR) with significant morbidity/mortality. Patients who receive multiple transplants are potentially at a…
  • 2022 American Transplant Congress

    Preemptive  Therapy for Cytomegalovirus (CMV) Disease Prevention in High-Risk CMV Donor Seropositive Recipient Seronegative (D+/R-) Liver Transplant Recipients in a Real-World Setting 

    K. M. Doss1, C. Kling1, M. R. Heldman1, N. Singh2, M. Wagener3, C. E. Fisher1, A. Limaye1

    1University of Washington, Seattle, WA, 2University of Pittsburgh, PIttsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose:  Preemptive therapy  (PET)  has  demonstrated superiority to antiviral prophylaxis  for  prevention of  cytomegalovirus (CMV)  disease  in  CMV  donor seropositive/recipient seronegative (D+R-)  liver transplant recipients …
  • 2022 American Transplant Congress

    Comparison of Cephalexin and Ciprofloxacin Prophylaxis for Urinary Tract Infection in Kidney Transplant Recipients

    N. A. Pauley, M. Fitzmaurice, A. Poparad-Stezar, B. Summers, A. Jantz

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    *Purpose: Compare efficacy and safety outcomes of patients (pts) that received alternative agents as prophylaxis (ppx) for urinary tract infection (UTI) after kidney transplant (KT)…
  • 2022 American Transplant Congress

    Early versus Delayed Cytomegalovirus Prophylaxis in High-Risk Kidney Transplant Recipients

    A. Hutchins1, M. Leick2, M. Keck2, J. S. McMullen2

    1Pharmacy, Houston Methodist Hospital, Houston, TX, 2Pharmacy, Nebraska Medicine, Omaha, NE

    *Purpose: The purpose of this study is to determine the effect of delaying cytomegalovirus (CMV) prophylaxis to day of discharge or post-operative day (POD) 7…
  • 2022 American Transplant Congress

    Donor-Derived Carbapenem-Resistant Gram-Negative Infections: Risk Mitigation Strategy in Solid Organ Transplant Improves Recipients Safety and Could Expand Donor Pool

    A. Mularoni1, E. Graziano1, M. Campanella1, A. Cervo2, M. Peghin3, F. Barbera1, P. Conaldi1, A. Luca1, P. A. Grossi4

    1ISMETT, Palermo, Italy, 2Department of Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico of Modena, Modena, Italy, 3Division of Infectious Diseases, ASUFC, Udine, Italy, 4Infectious and Tropical Diseases Unit, University of Insubria, Varese, Italy

    *Purpose: We implemented an Active Surveillance System (ASS) to mitigate the risk of unexpected carbapenem-resistant Gram-negative (CRGN) donor-derived infection (DDI) in solid organ transplant recipient…
  • 2022 American Transplant Congress

    Comparison of Perioperative Antibiotic Prophylaxis Regimens on Surgical Site Infections in Pancreas Transplant Recipients

    Z. A. Yetmar1, M. McCord2, B. Lahr3, A. Lemke2, P. G. Dean4, Y. C. Kudva5, M. T. Seville6, W. Bosch7, S. A. Bernard2, E. Beam1

    1Division of Infectious Diseases, Mayo Clinic, Rochester, MN, 2Department of Pharmacy, Mayo Clinic, Rochester, MN, 3Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 4Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, 5Division of Endocrinology, Diabetes, Metabolism & Nutrition, Mayo Clinic, Rochester, MN, 6Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ, 7Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL

    *Purpose: Pancreas transplant recipients are at high risk of surgical site infection (SSI), with rates ranging from 9-45%. Several risk factors for SSI have been…
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