ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Prophylaxis"

  • 2022 American Transplant Congress

    Donor-Derived Carbapenem-Resistant Gram-Negative Infections: Risk Mitigation Strategy in Solid Organ Transplant Improves Recipients Safety and Could Expand Donor Pool

    A. Mularoni1, E. Graziano1, M. Campanella1, A. Cervo2, M. Peghin3, F. Barbera1, P. Conaldi1, A. Luca1, P. A. Grossi4

    1ISMETT, Palermo, Italy, 2Department of Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico of Modena, Modena, Italy, 3Division of Infectious Diseases, ASUFC, Udine, Italy, 4Infectious and Tropical Diseases Unit, University of Insubria, Varese, Italy

    *Purpose: We implemented an Active Surveillance System (ASS) to mitigate the risk of unexpected carbapenem-resistant Gram-negative (CRGN) donor-derived infection (DDI) in solid organ transplant recipient…
  • 2022 American Transplant Congress

    Comparison of Perioperative Antibiotic Prophylaxis Regimens on Surgical Site Infections in Pancreas Transplant Recipients

    Z. A. Yetmar1, M. McCord2, B. Lahr3, A. Lemke2, P. G. Dean4, Y. C. Kudva5, M. T. Seville6, W. Bosch7, S. A. Bernard2, E. Beam1

    1Division of Infectious Diseases, Mayo Clinic, Rochester, MN, 2Department of Pharmacy, Mayo Clinic, Rochester, MN, 3Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 4Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, 5Division of Endocrinology, Diabetes, Metabolism & Nutrition, Mayo Clinic, Rochester, MN, 6Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ, 7Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL

    *Purpose: Pancreas transplant recipients are at high risk of surgical site infection (SSI), with rates ranging from 9-45%. Several risk factors for SSI have been…
  • 2022 American Transplant Congress

    Therapeutic Drug Monitoring of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Patients

    S. Sial, K. Cunningham, J. Moore, C. Dagostino, K. Lang, C. Kane

    Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Lung transplant patients are at an increased risk for invasive fungal infections and often require prophylaxis post-transplant, routinely including posaconazole at our institution. These…
  • 2022 American Transplant Congress

    Assessment of Letermovir as Universal Prophylaxis for Cytomegalovirus Infection in Lung Transplant Recipients

    L. F. Borges, T. Sparkman, K. Gutierrez, J. Banbury

    UAB Hospital, Birmingham, AL

    *Purpose: Cytomegalovirus (CMV) poses a significant concern in the post-operative management of lung transplant (LT) recipients. Current recommended prophylactic strategies with ganciclovir (GCV) or valganciclovir…
  • 2022 American Transplant Congress

    Preemptive Therapy in Cytomegalovirus (CMV) Seropositive Donor to Seronegative Recipient Liver Transplants

    J. Revollo, E. Aldag, K. Cooper, B. Noell, V. Casingal, K. Gajurel

    Transplant, Atrium Health's Carolinas Medical Center, Charlotte, NC

    *Purpose: To evaluate if a preemptive therapy strategy can prevent CMV disease and induce CMV seroconversion.*Methods: Observational data collection for CMV D+/R- adult liver transplant…
  • 2022 American Transplant Congress

    Risk for Loss of Hepatitis B Surface Antibody or Hepatitis B Reactivation in Kidney Transplant Recipients Receiving Lymphocyte Depleting Induction

    K. Paplaczyk1, C. Kane1, M. Kapugi1, K. Lang1, K. Cunningham1, C. D'Agostino1, J. Boike2

    1Pharmacy, Northwestern Memorial Hospital, Chicago, IL, 2Transplant Hepatology, Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Although used in over 60% of kidney transplant recipients, the impact of lymphocyte depleting induction on hepatitis B surface antibody (HBsAb) and hepatitis B…
  • 2022 American Transplant Congress

    Letermovir for Prophylaxis of Cytomegalovirus After Solid Organ Transplantation: A Single-Center, Observational Study

    T. N. Bullard1, C. A. Moore2, J. Dasigi2, L. M. Sacha2, C. A. Iasella3, K. A. Shimko2, E. K. McCreary4, F. P. Silveira4

    1Massachusetts General Hospital, Boston, MA, 2UPMC, Pittsburgh, PA, 3Univ of Pittsburgh, Pittsburgh, PA, 4Univ of Pittsburgh and UPMC, Pittsburgh, PA

    *Purpose: Cytomegalovirus (CMV) infections cause significant complications post-transplant; however, prophylactic medications are often limited by toxicities. Letermovir is a novel terminase inhibitor specific to CMV…
  • 2022 American Transplant Congress

    Recurrent Cytomegalovirus and the Role of Secondary Prophylaxis in Heart and Lung Transplant Recipients

    S. N. Finder1, K. Harrison1, M. Morrison1, S. Rega2, I. Feurer2, C. Gorsline3, G. Satyanarayana3, S. Hamel1

    1Department of Pharmaceutical Sciences, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt Transplant Center, Nashville, TN, 3Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN

    *Purpose: This study aimed to describe the incidence of cytomegalovirus (CMV) recurrence in heart and lung transplant recipients and the effect of secondary prophylaxis (SP)…
  • 2022 American Transplant Congress

    Effect of Micafungin Bridging on Prevention of Invasive Candidiasis Post Lung Transplantation

    C. Baladad1, M. Converse1, K. DeSear1, S. Karimi1, E. Rubido1, G. El Helou2, T. Pasley1

    1Pharmacy, University of Florida Health, Shands, Gainesville, FL, 2Infectious Diseases, University of Florida Health, Shands, Gainesville, FL

    *Purpose: This study aims to determine the effect of micafungin, added as a bridging agent to azole antifungal prophylaxis, in lung transplantation patients with positive…
  • 2022 American Transplant Congress

    An Interventional Study Using Cell-Mediated Immunity to Guide Primary Prophylaxis for CMV Infection in Organ Transplant Recipients: A Multi-Center Study

    J. T. Solera1, C. Cervera2, S. Hosseini1, J. Gill3, S. Shalhoub4, J. Zaltzman5, N. Pinzon1, A. Humar1, D. Kumar1

    1UHN, Toronto, ON, Canada, 2UAlberta, Edmonton, AB, Canada, 3UBC, Vancouver, BC, Canada, 4LHSC, London, ON, Canada, 5StMH, Toronto, ON, Canada

    *Purpose: There are limited interventional studies using CMV cell-mediated immunity to guide the duration of antiviral prophylaxis. We aimed to use CMV CMI to guide…
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