ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2015 American Transplant Congress

    Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)

    M. Tonsho,1 P. Spencer,1 T. Millington,1 A. Muniappan,1 A. Tena,2 R. Smith,3 R. Colvin,3 J. Allan,1,2 J. Madsen.1,2,4

    1MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 2Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 3Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 4Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

    BACKGROUNDThe role of vascularized thymus on tolerance induction has been well studied in swine recipients of kidney allografts, but not in NHP recipients of heart…
  • 2015 American Transplant Congress

    Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism in Nonhuman Primates

    T. Oura, D. Ko, J. O'Neil, S. Boskovic, O. Nadazdin, K. Hotta, K. Kawai, B. Cosimi, T. Kawai.

    Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

    Background: We have previously reported a successful induction of mixed chimerism and the long-term acceptance of renal allografts in MHC-mismatched nonhuman primates. In this study,…
  • 2015 American Transplant Congress

    Establishment of Diabetes Modeling in Common Marmoset

    W. Yuan,1 S. Fukuda,1 T. Inoue,2 D. Chujo,1 H. Okochi,1 E. Sasaki,2 M. Shimoda.1

    1National Center for Global Health and Medicine, Tokyo, Japan; 2Central Institute for Experimental Animals, Kawasaki, Japan.

    Background:Diabetic nonhuman primates (NHPs) are considered as the good models for both diabetes mellitus research and islet transplantation research safely into clinical applications. However, there…
  • 2015 American Transplant Congress

    T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 F. Leopardi,3 A. Gibby,1 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…
  • 2015 American Transplant Congress

    Eomesodermin Expression By Alloreactive Non-Human Primate CD8+ Memory T Cells: Influence of CTLA4Ig and Regulatory DC Infusion in Renal Allograft Recipients

    M. Ezzelarab,1 L. Lu,1 H. Guo,1 A. Zahorchak,1 W. Shufesky,1 D. Cooper,1 A. Morelli,1,2 A. Thomson.1,2

    1Surgery - Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Immunology, University of Pittsburgh, Pittsburgh, PA.

    Background:Memory T cells (Tmem), particularly those resistant to costimulation blockade (CoSB), are considered a major barrier to transplant tolerance. The T-box transcription factor Eomesodermin (Eomes)…
  • 2015 American Transplant Congress

    CMV prevalence in Mauritian and Indonesian Cynomolgus Macaques: Significance in Transplantation and CMV Disease Models

    K. Premanand,1 E. Szilagyi,1 J. Yu,1 R. Patel,1 A. Antony,1 M. Willman,2 D. Berman-Weinberg,2 D. Han,2 A. Vaidya,3 E. Silva,3 K. McHenry,3 D. Salomon,4 N. Kenyon,2 A. Bartholomew.1

    1University of Illinois, Chicago; 2Univerisity of Miami, Miami; 3University of Illinois, Urbana; 4Scripps, San Diego.

    Despite the finding that most macaques express high serologic titers of anti-CMV antibody, susceptibility to disease appears to be variable post-transplant. This observation led us…
  • 2015 American Transplant Congress

    Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates

    K. Hotta, A. Aoyama, P. Putheti, Y. Yamada, T. Ohura, R. Colvin, B. Cosimi, G. Benichou, T. Strom, T. Kawai.

    Transplant Center, Massachusetts General Hospital, Boston, MA.

    Background: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Although donor specific Th1 and…
  • 2015 American Transplant Congress

    Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 A. Gibby,1 F. Leopardi,3 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1,3

    1Emory Translant Center, Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…
  • 2015 American Transplant Congress

    CD28 Saturation by FR104, a Non-Activating CD28 Antagonist Fab in a Non-Human Primate Cardiac Allograft Model

    W. Sun,1 A. Azimzadeh,1 G. Braileanu,1 T. Zhang,1 D. Amoako,1 L. Burdorf,1 B. Vanhove,2 R. Pierson III.

    1Dept of Surgery, University of Maryland School of Medicine, Baltimore, MD; 2INSERM U643, Nantes, France.

    Background: Targeting CD28 costimulation pathway with a selective antagonist is a promising approach in tolerance induction. The extent to which novel therapeutic antibodies reach their…
  • 2015 American Transplant Congress

    Generation, Cryopreservation, Function and In Vivo Fate of Ex-Vivo Expanded Cynomolgus

    H. Guo,1 H. Zhang,1 L. Lu,1 M. Ezzelarab,1 A. Thomson.1,2

    1Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Background:Foxp3+ regulatory T cells (Treg) function to promote immune tolerance and prevent immunopathogenesis. Preclinical studies have demonstrated that adoptive transfer of Treg prevents rejection of…
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