ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2016 American Transplant Congress

    CXCL12 as Innovative Immune Isolating Chemokine for Microencapsulated Allo and Xeno-Transplantation in NHPs.

    M. Sremac,1 A. Saraya,1 O. Clemente,1 M. Penson,1 S. Chavan,3 N. Chronos,3 C. Schuetz,2 J. Lei,2 J. Markmann,2 T. Brauns,1 M. Poznansky.1

    1Infectious Disease/VIC, Massachusetts General Hospital, Boston, MA; 2Division of Transplantation, Massachusetts General Hospital, Boston, MA; 3VICapsys, Inc, Athens, GA.

    Introduction The purpose of this study is to determine whether a clinical-grade alginate-microencapsulant incorporating CXCL12, can protect and sustain the function of allo and/or adult…
  • 2016 American Transplant Congress

    Radiosensitive Cell Population Prolongs Graft Survival of Vascularized Composite Allografts in Non-Human Primates.

    M. Uluer, J. Woodall, W. Hassanein, U. Drhu, B. Bojovic, A. Nam, S. Bartlett, R. Barth.

    University of Maryland School of Medicine, Baltimore, MD.

    Background: Vascularized composite allografts (VCA) containing vascularized bone marrow (VBM) prolong graft survival. To help elucidate this protective immunomodulatory effect, we irradiated donor facial VCA…
  • 2016 American Transplant Congress

    Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?

    L. Cendales,1 M. Levine,2 S. Bartlett,3 J. Cheeseman,1 C. Drachenberg,3 W. Hancock,4 M. Joshi,1 A. Kirk,1 F. Leoopardi,1 S. Levin,2 M. Uluer,3 A. Selim,5 M. Song,1 W. Twaddell,3 L. Wang,4 Z. Wang,2 R. Barth.3

    1Surgery, Duke University, Durham, NC; 2University of Pennsylvania, Philadelphia, PA; 3University of Maryland School of Medicine, Baltimore, MD; 4Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; 5Pathology, Duke University, Durham, NC.

    Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…
  • 2016 American Transplant Congress

    Belatacept Immunotherapy Is Not Augmented by Blockade of Activated LFA-1 in a Nonhuman Primate Renal Transplant Model.

    K. Samy,1 M. Mulvihill,1 B. Collins,1 D. Lo,2 M. Song,1 F. Leopardi,1 A. Kirk.1,2

    1Department of Surgery, Duke University Medical Center, Durham, NC; 2Emory University, Atlanta, GA.

    Purpose: Belatacept specifically targets de novo alloimmune responses without off target side effects. However, resistant alloreactive memory T cells have complicated its use. LFA-1 therapy…
  • 2016 American Transplant Congress

    Combined CD122 and Costimulation Blockade Prolongs Allograft Survival by Controlling Expansion and Effector Function of Memory CD8 T Cells.

    D. Mathews,1 Y. Dong,1 L. Higginbotham,1 S. Kim,1 C. Breeden,1 J. Tso,2 A. Adams.1

    1Emory Transplant Center, Emory University, Atlanta, GA; 2JN Biosciences, Mountain View, CA.

    CD8 memory T cells rely on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. The addition of anti-CD122 to costimulation blockade prolongs graft…
  • 2016 American Transplant Congress

    Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.

    M. Tonsho,1 G. Benichou,1 R. Yu,1 S. Boskovic,1 R. Colvin,1,2 E. Farkash,2 R.-N. Smith,2 J. Allan,1,4 A. Cosimi,1 T. Kawai,1,3 J. Madsen.1,4

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; 2Department of Pathology, Massachusetts General Hospital, Boston, MA; 3Department of Surgery, Massachusetts General Hospital, Boston, MA; 4Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.

    (BACKGROUND)Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the…
  • 2016 American Transplant Congress

    Non-Human Primate Lung Allograft Survival Is Prolonged by IL-6 Inhibition and ATG Treatment Possibly Through Expansion of Peripheral Regulatory T Cells.

    A. Aoyama, M. Tonsho, R.-N. Smith, R. Colvin, A. Dehnadi, J. Madsen, A. Cosimi, G. Benichou, T. Kawai, J. Allan.

    Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    BACKGROUND: Inflammatory responses have been linked to the development of acute and chronic rejection after lung transplantation in various models. Previous studies have demonstrated that…
  • 2016 American Transplant Congress

    Acute Rejection in Non-Human Primates Treated with Belatacept Is Mediated by a Unique CD8 Memory Subset.

    D. Mathews,1 W. Wakwe,1 M. Lowe,1 C. Breeden,1 F. Leopardi,1 A. Farris,1 M. Song,1 E. Strobert,2 J. Jenkins,2 C. Larsen,1 R. Townsend,3 A. Adams.1

    1Emory Transplant Center, Emory University, Atlanta, GA; 2Yerkes National Primate Research Center, Atlanta, GA; 3Bristol Myers-Squibb Pharmaceutical Research Institute, Princeton, NJ.

    Belatacept is a high affinity version of the fusion protein CTLA4-Ig that blocks CD28 mediated T cell costimulation, providing a more targeted/less toxic form of…
  • 2016 American Transplant Congress

    Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.

    M. Ezzelarab,1 H. Zhang,1 L. Lu,1 H. Guo,1 A. Zahorchak,1 R. Wiseman,2 M. Nalesnik,3 J. Bhama,1 D. Cooper,1 A. Thomson.1,4

    1Surgery, University of Pittsburgh, Starzl Institute, Pittsburgh, PA; 2Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI; 3Pathology, University of Pittsburgh, Pittsburgh, PA; 4Immunology, University of Pittsburgh, Pittsburgh, PA.

    Background:The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well-established. Few studies have addressed the…
  • 2015 American Transplant Congress

    Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation

    C. Burghuber,1,2 J. Kwun,1 E. Page,1 A. Gibby,1 F. Leopardi,3 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1,3

    1Emory Translant Center, Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…
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