2017 American Transplant Congress
Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.
Activation of recipient T cells recognizing allogeneic MHC molecules displayed on donor leukocytes is known to trigger acute allograft rejection (direct allorecognition). Recently, we have…2017 American Transplant Congress
Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model.
1Surgery, Duke Transplant Center, Durham, NC; 2Surgery, Samsung Medical Center, Seoul, Korea
[Introduction] The presence of donor-specific antibodies (DSA) leads to antibody-mediated rejection (AMR) and decreased graft survival. Therefore efforts continue to be made to reduce DSA…2017 American Transplant Congress
Measurement of Dissolved Oxygen by 19F MRI of Microcapsules Implanted IP in Non-Human Primates.
Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…2017 American Transplant Congress
Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans.
1U of Cincinnati, Cincinnati; 2Duke, Durham; 3Cincinnati Childrens, Cincinnati
Proteasome inhibitor (PI)-based desensitization (DS) in humans has demonstrated variable reduction in HLA antibody levels that is often associated with variable rebound following treatment cessation.The…2017 American Transplant Congress
Preservation of Musculoskeletal Components in Vascularized Composite Allograft Skin Rejection.
University of Maryland School of Medicine, Baltimore, MD
Background: Severe or chronic rejection of vascularized composite allografts (VCA) has resulted in graft loss and patient deaths. 'Split tolerance' has been defined in patterns…2017 American Transplant Congress
Non-Invasive Detection of Rejection with ImmunoPET Imaging.
Current approaches to detect and diagnose rejection are retrospective and/or invasive. These methods assess the extent of end organ damage by insensitive and non-specific measures…2017 American Transplant Congress
Accelerated De-Novo Donor-Specific Antibody-Mediated Rejection in a Non-Human Primate Model of Renal Transplantation.
Surgery - Division of Transplantation, University of Wisconsin-Madison, Madison, WI
The development of accelerated antibody-mediated rejection (ABMR) is associated with early allograft dysfunction and premature graft loss. In animals, pre-sensitization is usually required in order…2016 American Transplant Congress
Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model.
1Surgery, Duke University, Durham; 2Surgery, Emory University, Atlanta.
Sensitized patients comprise a significant proportion (30%) of candidates on the waiting list for transplantation. With recent evidence that the presence of donor-specific antibodies (DSA)…2016 American Transplant Congress
Late Renal Xenograft Failure Is Antibody-Mediated: Description of the Longest-Reported Survival in Pig-to-Primate Renal Xenotransplantation.
Introduction. Xenotransplantation has the potential to alleviate the organ supply shortage, yet pig-to-primate renal xenotransplant has met limited success due to natural preformed anti-pig antibody.…2016 American Transplant Congress
Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.
[Background] Non-human primate models of sensitization provide great preclinical models to investigate the mechanisms of antibody-mediated rejection or desensitization. Now there a growing interest on…
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