2017 American Transplant Congress
Preservation of Musculoskeletal Components in Vascularized Composite Allograft Skin Rejection.
University of Maryland School of Medicine, Baltimore, MD
Background: Severe or chronic rejection of vascularized composite allografts (VCA) has resulted in graft loss and patient deaths. 'Split tolerance' has been defined in patterns…2017 American Transplant Congress
Non-Invasive Detection of Rejection with ImmunoPET Imaging.
Current approaches to detect and diagnose rejection are retrospective and/or invasive. These methods assess the extent of end organ damage by insensitive and non-specific measures…2017 American Transplant Congress
Accelerated De-Novo Donor-Specific Antibody-Mediated Rejection in a Non-Human Primate Model of Renal Transplantation.
Surgery - Division of Transplantation, University of Wisconsin-Madison, Madison, WI
The development of accelerated antibody-mediated rejection (ABMR) is associated with early allograft dysfunction and premature graft loss. In animals, pre-sensitization is usually required in order…2017 American Transplant Congress
Induction of Delayed Renal Allograft Tolerance Using Only Clinically Available Reagents in Non-Human Primates.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: We have previously reported successful induction of renal allograft tolerance following a period of conventional immunosuppression (Delayed tolerance) using nonmyeloablative conditioning that included anti-CD154…2017 American Transplant Congress
Patterns of Monocyte Differentiation and Activation in a Non-Human Primate Model of Brain Death.
Surgery - Division of Transplantation, University of Wisconsin-Madison, Madison, WI
Brain-death (BD) induces a systemic inflammatory response known to impair tissue perfusion and promote graft immunogenicity. Monocytes play a significant role in the regulation of…2017 American Transplant Congress
Induction of Mixed Chimerism to Prolong Liver Allograft Survival in Cynomolgus Monkeys.
CCTI, Columbia University, New York, NY
Purpose: Spontaneous liver tolerance occurs in highly selected patients with stable liver function. There is an unmet need for a safe and reliable regimen allowing…2017 American Transplant Congress
Immune Tolerance Monitoring in Renal Allograft Tolerance Induced by Transient Mixed Chimerism in Nonhuman Primates.
Center for Transplant Science, Massachusetts General Hospital, Boston, MA
Background: We have previously reported donor specific expansion of regulatory T cells (Tregs) in nonhuman primate (NHP) recipients which achieved renal allograft tolerance after induction…2017 American Transplant Congress
Mesenchymal Stem Cells Suppress T Cell Proliferation and Improve Allograft Survival in a Nonhuman Primate Transplant Model.
Emory Transplant Center, Emory University, Atlanta, GA
Background: The clinical implementation of costimulation blockade (CoB) provides long-term benefit to transplant recipients, with the short-term drawback of increased acute rejection. Cellular therapies are…2017 American Transplant Congress
Dual Costimulatory Blockades Failed to Achieve Transplant Tolerance Despite Induction of Mixed Chimerism in NHPs.
Background: Our previous studies showed that substantial deletion of CD8+ memory T cells (TMEM) was necessary to induce mixed chimerism (MC) and allograft tolerance when…2017 American Transplant Congress
Autologous Expanded Tregs and Porcine Hematopoietic Cells to Prolong Xenogeneic Pig Skin Graft Acceptance in Baboons.
Background: Mixed chimerism (MC) has been shown to induce tolerance to allogeneic organs and has shown promise for application to xenotransplants, although long-term tolerance has…
- « Previous Page
- 1
- …
- 4
- 5
- 6
- 7
- 8
- …
- 10
- Next Page »