ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Primates"

  • 2017 American Transplant Congress

    Timing of Mesenchymal Stem Cell Infusions Affects Rejection Free and Overall Islet Allograft Survival.

    N. Kenyon,1 M. Willman,1 D. Han,1 A. Rabassa,1 W. Diaz,1 R. Leeman,1 K. McHenry,2 D. Salomon,3 A. Bartholomew,4 N. Kenyon,1 D. Berman.1

    1Diabetes Research Institute, University of Miami, Miami, FL; 2University of Illinois at Urbana-Champaign, Champaign, IL; 3The Scripps Research Institute, La Jolla, CA; 4University of Illinois at Chicago, Chicago, IL

    We recently demonstrated that autologous, bone marrow-derived mesenchymal stem cells (MSC) promote allogeneic islet engraftment and survival in a streptozotocin induced, cynomolgus monkey model of…
  • 2017 American Transplant Congress

    mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.

    M. Matsunami,1 T. Oura,1 I. Rosales,2 R.-N. Smith,2 B. Adam,3 M. Mengel,3 A. Cosimi,1 R. Colvin,2 T. Kawai.1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 2Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 3Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

    Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…
  • 2017 American Transplant Congress

    D-Dimer Level, in Association with Humoral Responses, Negatively Correlates with Survival of Porcine Islet Grafts in Nonhuman Primates with Immunosuppression.

    H. Kang,1 H. Lee,1 E. Park,1 J. Kim,2 B. Min,2 C.-G. Park.2

    1Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea; 2Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea

    Background: Several immunosuppression (IS) regimens achieve long-term graft survival in nonhuman primates (NHPs) after porcine islet transplantation (PITx), but their success rates vary. To understand…
  • 2017 American Transplant Congress

    Lymphoid Isolation as an Adjuvant Maneuver for Belatacept-Based Immunotherapy.

    M. Mulvihill,1 K. Samy,2 R. Davis,1 F. Leopardi,1 B. Collins,1 A. Kirk.1

    1Surgery, Duke University Medical Center, Durham, NC; 2Surgery, Indianapolis University Medical Center, Indianapolis, IN

    Purpose: Belatacept targets de novo alloimmune responses with minimal off target effects in renal transplantation, though adjuvant therapy is required for control of costimulation-blockade resistant…
  • 2017 American Transplant Congress

    Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.

    J. Marino, K. Robinson, J. Paster, I. Hanekamp, J. Madsen, G. Benichou.

    Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Activation of recipient T cells recognizing allogeneic MHC molecules displayed on donor leukocytes is known to trigger acute allograft rejection (direct allorecognition). Recently, we have…
  • 2017 American Transplant Congress

    Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model.

    J. Kwun,1 B. Ezekian,1 M. Manook,1 E. Branum,1 V. Curfman,1 J. Park,1,2 K. Freishlag,1 J. Yoon,1 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Surgery, Samsung Medical Center, Seoul, Korea

    [Introduction] The presence of donor-specific antibodies (DSA) leads to antibody-mediated rejection (AMR) and decreased graft survival. Therefore efforts continue to be made to reduce DSA…
  • 2017 American Transplant Congress

    Measurement of Dissolved Oxygen by 19F MRI of Microcapsules Implanted IP in Non-Human Primates.

    S. Safley,1 M. Graham,2 M. Garwood,3 K. Papas,5 B. Weegman,3,4 G. Barber,1 E. Lin,1 J. Leisen,7 A. Sambanis,6 B. Hering,2 C. Weber.1

    1Surgery, Emory University, Atlanta, GA; 2Surgery, University of Minnesota, Minneapolis, MN; 3Radiology, University of Minnesota, Minneapolis, MN; 4Sylvatica Biotech, Inc., Charleston, SC; 5Surgery, University of Arizona, Tucson, AZ; 6School of Chemical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 7School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA

    Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…
  • 2017 American Transplant Congress

    Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans.

    J. Driscoll,1 S. Knechtle,2 J. Kwun,2 S. Tremblay,1 N. Salomonis,3 S. Potter,3 B. Aronow,3 M. Manook,2 R. Alloway,1 H. Singh,3 E. Woodle.1

    1U of Cincinnati, Cincinnati; 2Duke, Durham; 3Cincinnati Childrens, Cincinnati

    Proteasome inhibitor (PI)-based desensitization (DS) in humans has demonstrated variable reduction in HLA antibody levels that is often associated with variable rebound following treatment cessation.The…
  • 2017 American Transplant Congress

    Preservation of Musculoskeletal Components in Vascularized Composite Allograft Skin Rejection.

    E. Buckingham, A. Khalifeh, M. Uluer, W. Hassenein, C. Drachenberg, A. Nam, W. Twaddell, S. Bartlett, R. Barth.

    University of Maryland School of Medicine, Baltimore, MD

    Background: Severe or chronic rejection of vascularized composite allografts (VCA) has resulted in graft loss and patient deaths. 'Split tolerance' has been defined in patterns…
  • 2017 American Transplant Congress

    Non-Invasive Detection of Rejection with ImmunoPET Imaging.

    D. Mathews,1 K. Lindsay,2 P. Santangelo,2 Y. Dong,1 J. Tso,3 A. Adams.1

    1Department of Surgery, Emory University, Atlanta, GA; 2Department of Biomedical Engineering, Georgia Tech, Atlanta, GA; 3JN Biosciences LLC, Mountain View, CA

    Current approaches to detect and diagnose rejection are retrospective and/or invasive. These methods assess the extent of end organ damage by insensitive and non-specific measures…
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