2015 American Transplant Congress
Donor Specific Expansion of Regulatory T-Cells Was Associated With Allograft Tolerance Induced By Transient Mixed Chimerism in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported successful induction of solid organ allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Since these recipients achieved…2015 American Transplant Congress
Selective CD28 Blockade With or Without CD40-CD154 Blockade Promotes Cardiac Allograft Protection in Non-Human Primates
1Surgery, University of Maryland School of Medicine, Baltimore, MD; 2INSERM, U643, Nants, France.
Aim: Selective targeting CD28:B7 costimulation without interfering with CTLA-4-dependent immune regulation is theoretically an attractive approach to modulate pathogenic T cell-dependent immunity. We previously reported…2015 American Transplant Congress
CD28-Directed Therapy Prolongs Survival in a Non-Human Primate Kidney Transplant Model
Introduction. Costimulation blockade using belatacept has the potential to improve long-term renal function and reduce cardiovascular risk by avoiding calcineurin inhibitors, yet higher rates and…2015 American Transplant Congress
Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft
1INSERM, UMR1064, ITUN, Nantes, France; 2Effimune SAS, Nantes, France.
B7 molecules on antigen-presenting cells interact with CD28 and CTLA4 on T lymphocytes to control TCR-mediated signals. Whereas it is highly efficient to block T…2015 American Transplant Congress
Impact of Human Mutant TGF-β1/Fc Protein On Memory and Regulatory CD4+T Cells Following Lymphodepletion in Rhesus Monkeys
Background:Tolerance to allografts is essential to avoid chronic immunosuppression and to promote long term graft function. Transforming growth factor- β plays a key role in…2015 American Transplant Congress
Immunosuppression With Anti-CD40 mAb and Rapamycin for Islet and Kidney Co-Transplantation in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: For patients with end-stage renal disease secondary to type 1 diabetes mellitus, islet and kidney co-transplantation can be an ideal transplant option. However, a…
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