Articles tagged "Preservation"

2018 American Transplant Congress
One-Pump versus Two-Pump Normothermic Ex Vivo Perfusion Machines in Discarded Human Livers
A. Hassan, Q. Liu, D. Pezzati, A. Nassar, B. Soliman, M. Blum, P. Grady, G. Iuppa, T. Uso, J. Fung, K. Abu-Elmagd, C. Quintini.
Transplant Surgery, Cleveland Clinic, Cleveland.
Introduction:Physiologic flows and pressures need to be provided by the ex vivo liver perfusion device. We hypothesized that the 1-pump designed machines would provide the…
2018 American Transplant Congress
Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid
Y. de Vries,^1,2 A. Matton,^1,2 S. Karangwa,^1,2 M. Nijsten,³ R. de Kleine,² A. van den Berg,⁴ V. de Meijer,² P. Meyer,⁵ M. de Boer,² R. Porte.²
¹Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; ²Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; ³Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.
While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation for Fatty Liver Grafts in Human
W. Ju, S. Huang, Z. Guo, G. Chen, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
BACKGROUND&AIMS: Fatty liver diseases have led to a continuous increase of available donor livers containing fat. Fatty liver grafts were identified as an independent risk…
2018 American Transplant Congress
Unraveling the Neuroimmunological Pathways Surrounding Brain Death: Systematic Study of Clinically Relevant Serum Biomarker Changes during Donor Management from Admission to Procurement
K. Bera, M. LoFaro, H. Huang, S. Maslau, R. Ploeg.
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Donation after brain death (BD) remains an important source of transplanted organs worldwide and it has been shown that BD causes a hostile environment with…
2017 American Transplant Congress
36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.
J. Magliocca,¹ J. Markmann,² M. Abouljoud,³ M. Ghobrial,⁴ A. Demetris.⁵
¹Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; ²Department of Surgery Division of Transplantation, Massachusetts General Hospital, Boston, MA; ³Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ⁴Surgery - General, Houston Methodist Hospital, Houston, TX; ⁵Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…
2017 American Transplant Congress
Assessment and Transplantation of Declined Human Kidneys Using Ex-Vivo Normothermic Kidney Perfusion.
S. Hosgood,¹ M. Hamed,¹ A. Sawpaul,² R. Figueiredo,² K. Saeb-Parsy,¹ C. Wilson,² M. Nicholson.¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Transplantation, Transplant Institute, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom
PurposeThe aim of this study was to make more kidneys available for transplantation by using ex-vivo normothermic kidney perfusion (EVKP) technology to assess the quality…
2017 American Transplant Congress
Outcomes from a Multinational Randomised Controlled Trial Comparing Normothermic Machine Perfusion with Static Cold Storage in Human Liver Transplantation.
D. Nasralla,¹ Consortium for Organ Preservation in Europe Liver Research Group,¹ R. Ploeg,¹ C. Coussios,² P. Friend.¹
¹Nuffield Department of Surgical Sciences, Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom; ²Department of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
Introduction:By perfusing a liver with oxygenated blood, medications and nutrients at 37oC, normothermic machine perfusion (NMP) may improve outcomes after liver transplantation when compared with…
2017 American Transplant Congress
Risk Prediction Model for Delayed Graft Function in a Cohort of Brazilian Kidney Transplantation from Deceased Donors: What You See Is Not What You Get.
S. Costa,^1,2 T. Sandes-Freitas,^1,2 E. Daher,² R. Esmeraldo.¹
¹Hospital Geral de Fortaleza, Fortaleza, Brazil; ²Federal University of Ceara, Fortaleza, Brazil
Introduction: The estimated frequency of delayed graft function (DGF) in Brazil ranges from 50 to 70%, despite deceased donor and recipient characteristics similar to those…
2017 American Transplant Congress
Development of an Automatic Regulated Normothermic Kidney Preservation Device for Long-Term Organ Perfusion.
A. Weissenbacher,¹ O. Boubriak,² L. Lo Faro,¹ R. Ploeg,¹ J. Hunter,¹ D. Voyce,³ N. Mikov,³ A. Cook,³ C. Coussios,² P. Friend.¹
¹Nuffield Department of Surgical Sciences, Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom; ²Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom; ³OrganOx Limited, Magdalen Centre, Oxford Science Park, Oxford, United Kingdom
BackgroundNormothermic kidney perfusion for a period of 24 hours or longer would offer significant clinical advantages. It would enable clinicians to investigate the condition of…
2017 American Transplant Congress
Using Scheduled Commercial Flights for Transport of Liver for Transplant.
V. Gupta,¹ A. Chandra,¹ M. Singh,¹ V. Gupta,¹ S. Kumar,¹ P. Joshi,¹ P. Sharma,² H. Hasan,³ P. Srivastava,⁴ M. Khan,¹ Z. Arshad,¹ R. Kant.¹
¹King George's Medical University, Lucknow, Uttar Pradesh, India; ²Uttar Pradesh Chief Minister Office, Lucknow, Uttar Pradesh, India; ³Traffic Directorate, Lucknow, Uttar Pradesh, India; ⁴Airport Director, Amausi Airport, Airports Authority of India, Lucknow, Uttar Pradesh, India
Transport of liver procured from a brain dead donor (BDD) to the receiving hospital by chartered private flight (PF) is a costly endeavour. Also the…