ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation"

  • 2018 American Transplant Congress

    Ex-Vivo Subnormothermic Oxygenated Machine Perfusion of Rodent Hindlimb: Feasibility Study to Elongate Preservation Time of Vascularized Composite Allograft

    L. Burlage,1,2 A. Lellouch,3,4 S. Tessier,1 C. Pendexter,1 S. Cronin,1 M. Schol,3 M. Randolph,3 R. Porte,2 L. Lantieri,4 C. Cetrulo,3 K. Uygun.1

    1Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; 2Surgery, University Medical Center Groningen, Groningen, Netherlands; 3Plastic Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; 4Plastic Surgery, European George Pompidou Hospital, Paris, France.

    PURPOSE: A pressing challenge in the field of VCA is adequate tissue preservation. Static cold preservation, successfully used in field of solid organ transplantation, greatly…
  • 2018 American Transplant Congress

    The Superiority of Plasma Enriched Perfusate for Assessment of Donor Kidneys in an Ex-Vivo Normothermic Perfusion (EVNP) Setting

    J. Palma, I. Palma, Y. Smolin, A. Perry, J. Sageshima, R. Perez.

    Surgery, Transplant Division, UC Davis Health System, Sacramento, CA.

    EVNP has been used to assess and repair marginal organs prior to transplantation but the optimal perfusate composition is unknown. We hypothesize that EVNP with…
  • 2018 American Transplant Congress

    The Role of Ex Vivo Normothermic Preservation in Minimizing Postreperfusion Syndrome in Liver Transplantation

    A. Hassan, J. Cywinski, Q. Liu, D. Pezzati, D. Yang, L. Liu, G. Iuppa, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.

    Transplant Surgery, Cleveland Clinic, Cleveland.

    Background:Graft reperfusion holds a major challenge during liver transplantation. NMP may improve post-reperfusion hemodynamics, reduce vasopressor and blood product transfusion.Methods:15 patients with liver transplantation after…
  • 2018 American Transplant Congress

    Ex-Situ Normothermic Human Upper Extremity Perfusion: Preliminary Report

    V. Fahradyan, E. Dalla Pozza, M. Madajka, K. Cho, N. Dawlagala, E. Duraes, H. Shah, S. Al-deen Said, C. Ordenana, F. Papay, A. Rampazzo, B. Bassiri Gharb.

    Plastic Surgery, Cleveland Clinic, Cleveland, OH.

    Purpose: Ischemia time remains a significant limiting factor for successful extremity replantation and transplantation. Normothermic ex-situ perfusion is a novel method of a limb preservation…
  • 2017 American Transplant Congress

    Combined Perfusion of Liver and Kidney Enhances the Protective Effects of Normothermic Perfusion on Donation After Cardiac Death Porcine Livers.

    Z. Guo, F. Ji, X. He, G. Chen.

    The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Aims It has been showed that combined liver-kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether the combined…
  • 2017 American Transplant Congress

    Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.

    P. Urbanellis,1 M. Hamar,1 I. Linares,1 D. Kollmann,1 C. Cassol,2 R. John,2 P. Yip,1 I. Mucsi,1 A. Ghanekar,1 D. Bagli,3 D. Grant,1 L. Robinson,4 M. Selzner.1

    1Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; 2Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; 3Departments of Surgery (Urology) and Physiology, The Hospital for Sick Children, Toronto, ON, Canada; 4Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    Background: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could promote improved marginal graft function compared…
  • 2017 American Transplant Congress

    Proteins in Preservation Fluid Predict Delayed Graft Function of Kidneys from Donors After Circulatory Death.

    B. van Balkom,1 H. Gremmels,1 L. Ooms,4 R. Toorop,2 F. Dor,5 O. de Jong,1 L. Michielsen,1 G. de Borst,2 W. de Jager,3 A. van Zuilen,1 M. Verhaar.1

    1Nephrology and Hypertension, UMC Utrecht, Utrecht, Netherlands; 2Vascular Surgery, UMC Utrecht, Utrecht, Netherlands; 3Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands; 4Surgery, Erasmus MC, Rotterdam, Netherlands; 5Renal and Transplant Services, Imperial College Healthcare NHS Trust, London, United Kingdom

    Background and objectivesKidney transplantation is the preferred treatment for end-stage kidney disease, and donor kidney shortage urges proper donor-recipient matching. Zero-hour biopsies provide predictive value…
  • 2017 American Transplant Congress

    Split Liver Ex-situ Oxygenated Machine Perfusion: A Novel Approach to Organ Preservation and Treatment.

    N. Karimian,1 V. Huang,1 S. Geerts,1 S. Mert,1 I. Beijert,2 F. Fontan,1 M. Aburawi,1 R. Porte,2 K. Uygun,1 J. Markmann,1 H. Yeh.1

    1Division of Transplantation, Massachusetts General Hospital, Boston; 2Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands

    Ex-situ machine perfusion (MP) is a promising method to improve organ viability prior to transplantation and is being used in various clinical trials worldwide. However,…
  • 2017 American Transplant Congress

    Cost-Effectiveness of Renal Machine Perfusion Use After Long Cold Ischemia Time.

    A. Matos,1 D. Malheiro,3 S. Morgado,1 L. Requi[acirc]o-Moura,1 M. Souza-Durão,1,2 E. Tonato,1 M. Nogueira,1 M. Borrelli,1 A. Pacheco-Silva.1,2

    1Renal Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil; 3Health Economics Department, Hospital Israelita Albert Einstein, São Paulo, Brazil

    High cold ischemia time (CIT) and inadequate care of donors in Brazil lead to a high incidence of delayed graft function (DGF), 60%-70%, and as…
  • 2017 American Transplant Congress

    36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.

    J. Magliocca,1 J. Markmann,2 M. Abouljoud,3 M. Ghobrial,4 A. Demetris.5

    1Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; 2Department of Surgery Division of Transplantation, Massachusetts General Hospital, Boston, MA; 3Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 4Surgery - General, Houston Methodist Hospital, Houston, TX; 5Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…
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