Articles tagged "Preservation"

2018 American Transplant Congress
Assessment of Hepatic Ischemia-Reperfusion Injuries by NRF2-Dependent Transcriptional Activities of Bile Transporters in Rats
J. Kim,¹ A. Martin,¹ J. Yee,¹ L. Fojut,¹ A. Geurts,² K. Oshima,³ M. Zimmerman,¹ J. Hong.¹
¹Surgery, Medical College of Wisconsin, Milwaukee, WI; ²Physiology, Medical College of Wisconsin, Milwaukee, WI; ³Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: The effect of hepatic ischemia and reperfusion injury (IRI) on bile transporter (BT) gene expression and the role of Nrf2 in BT regulation during…
2018 American Transplant Congress
A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture
J. Friedman,¹ M. Samamrco,¹ L. Marrero,¹ B. Bunnell,¹ D. Spyropoulos.²
¹Tulane University, New Orleans; ²MUSC, Charleston.
Backgroud: Only 20% of donor lungs are used for transplant and 10 y survival of recipients is low. Many patients die within 30 d of…
2018 American Transplant Congress
A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia
A. Konvalinka,^1,4 T. Tokar,² S. Reid,⁴ P. Urbanellis,⁴ M. Hamar,⁴ M. Kaths,⁴ I. Jurisica,² L. Robinson,^4,3 M. Selzner.^4,5
¹Medicine/Nephrology, University Health Network, Toronto, ON, Canada; ²Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; ³Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁵Surgery/General Surgery, University Health Network, Toronto, ON, Canada.
Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…
2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ S. Ganesh,¹ R. John,¹ P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,² A. Konvalinka,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹University Health Network, Toronto, ON, Canada; ²SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…
2017 American Transplant Congress
Outcomes from a Multinational Randomised Controlled Trial Comparing Normothermic Machine Perfusion with Static Cold Storage in Human Liver Transplantation.
D. Nasralla,¹ Consortium for Organ Preservation in Europe Liver Research Group,¹ R. Ploeg,¹ C. Coussios,² P. Friend.¹
¹Nuffield Department of Surgical Sciences, Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom; ²Department of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
Introduction:By perfusing a liver with oxygenated blood, medications and nutrients at 37oC, normothermic machine perfusion (NMP) may improve outcomes after liver transplantation when compared with…
2017 American Transplant Congress
Risk Prediction Model for Delayed Graft Function in a Cohort of Brazilian Kidney Transplantation from Deceased Donors: What You See Is Not What You Get.
S. Costa,^1,2 T. Sandes-Freitas,^1,2 E. Daher,² R. Esmeraldo.¹
¹Hospital Geral de Fortaleza, Fortaleza, Brazil; ²Federal University of Ceara, Fortaleza, Brazil
Introduction: The estimated frequency of delayed graft function (DGF) in Brazil ranges from 50 to 70%, despite deceased donor and recipient characteristics similar to those…
2017 American Transplant Congress
Development of an Automatic Regulated Normothermic Kidney Preservation Device for Long-Term Organ Perfusion.
A. Weissenbacher,¹ O. Boubriak,² L. Lo Faro,¹ R. Ploeg,¹ J. Hunter,¹ D. Voyce,³ N. Mikov,³ A. Cook,³ C. Coussios,² P. Friend.¹
¹Nuffield Department of Surgical Sciences, Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom; ²Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom; ³OrganOx Limited, Magdalen Centre, Oxford Science Park, Oxford, United Kingdom
BackgroundNormothermic kidney perfusion for a period of 24 hours or longer would offer significant clinical advantages. It would enable clinicians to investigate the condition of…
2017 American Transplant Congress
Using Scheduled Commercial Flights for Transport of Liver for Transplant.
V. Gupta,¹ A. Chandra,¹ M. Singh,¹ V. Gupta,¹ S. Kumar,¹ P. Joshi,¹ P. Sharma,² H. Hasan,³ P. Srivastava,⁴ M. Khan,¹ Z. Arshad,¹ R. Kant.¹
¹King George's Medical University, Lucknow, Uttar Pradesh, India; ²Uttar Pradesh Chief Minister Office, Lucknow, Uttar Pradesh, India; ³Traffic Directorate, Lucknow, Uttar Pradesh, India; ⁴Airport Director, Amausi Airport, Airports Authority of India, Lucknow, Uttar Pradesh, India
Transport of liver procured from a brain dead donor (BDD) to the receiving hospital by chartered private flight (PF) is a costly endeavour. Also the…
2017 American Transplant Congress
Combined Perfusion of Liver and Kidney Enhances the Protective Effects of Normothermic Perfusion on Donation After Cardiac Death Porcine Livers.
Z. Guo, F. Ji, X. He, G. Chen.
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Aims It has been showed that combined liver-kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether the combined…
2017 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ C. Cassol,² R. John,² P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,³ D. Grant,¹ L. Robinson,⁴ M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ³Departments of Surgery (Urology) and Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁴Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
Background: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could promote improved marginal graft function compared…