Articles tagged "Preservation"

2019 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Preservation Consistently Improves Extreme Marginal Graft Function Compared to Hypothermic Machine Perfusion
P. Urbanellis¹, M. Hamar¹, I. Linares¹, D. Kollmann¹, S. Ganesh¹, F. Oquendo¹, M. Sharma¹, R. John¹, A. Ghanekar¹, I. Mucsi¹, D. Bagli², A. Konvalinka¹, L. Robinson³, M. Selzner¹
¹Multi-Organ Transplantation Program, University Health Network, Toronto, ON, Canada, ²Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP promoted improved marginal graft function compared to…
2019 American Transplant Congress
A Novel Multi-Thermic, Antiseptic, and Anthropomorphic System for Ex-Vivo Face Perfusion
J. W. Etra¹, J. Brassil², F. A. Chang¹, S. A. Fidder¹, D. S. Cooney¹, G. Brandacher¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Functional Circulation LLC, Northbrook, IL
*Purpose: Facial disfigurement is profoundly disabling, and great relief follows resolution by facial transplantation, now a technical reality at multiple centers worldwide. However, distance between…
2019 American Transplant Congress
Protection of the Donor Kidney Vascular Endothelium by Ex-Vivo Perfusion with a Pan-Caspase Inhibitor
R. Plenter¹, S. Jain², T. Nydam¹, A. jani²
¹Transplant Microsurgery Program, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Orthotopic kidney transplantation is a life-saving therapeutic option for patients with end stage organ failure. Pulsatile perfusion (PP) of deceased donor kidneys is increasingly…
2019 American Transplant Congress
Perfluorocarbon (PFC) Solutions for Organ Preservation
N. Battula, T. Parsons, J. Zhu, C. Giordano, A. Esnakula, B. Spiess, M. Johnson, A. Zarrinpar, K. Andreoni
University of Florida, Gainesville, FL
*Purpose: The current status of organ transplantation demands consideration of extended criteria (ECD) brain dead donors (DBD) as well as donation after circulatory death (DCD)…
2019 American Transplant Congress
Pancreatic Extracellular Matrix Improves Human Islet Culture and Function In Vitro
Y. Shindo, R. Pouillot, B. M. Young, P. Link, R. L. Heise, M. F. Levy, M. A. Kanak
Virginia Commonwealth University, Richmond, VA
*Purpose: Islet transplantation is a thriving therapy for patients with Chronic Pancreatitis and Type-1 Diabetes. Within the pancreas, the islets are surrounded by Extracellular Matrix…
2019 American Transplant Congress
Proteomics Reveals Molecular Window and Metabolism of Normothermically Perfused Human Kidneys
A. Weissenbacher¹, H. Huang², A. Thorne³, L. M. Lo Faro³, J. Hunter³, R. Ploeg³, C. C. Coussios⁴, P. J. Friend³, B. Kessler⁵
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department o Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ⁵Nuffield Department o Medicine, Target Discovery Instituteiscovery Institute, University of Oxford, Oxford, United Kingdom
*Purpose: We have shown that 24h normothermic kidney perfusion (NKP) with urine recirculation (URC) is superior to non URC for maintaining homeostasis previously. However, the…
2019 American Transplant Congress
Impact of an Intra-Abdominal Cooling Device during Open Kidney Transplantation in Pigs
A. Longchamp¹, R. P. Meier², N. Colucci³, A. Balaphas³, L. Orci³, A. Nastasi³, G. Longchamp¹, S. Moll⁴, A. Klauser⁵, F. Lazeyras⁵, M. Pascual⁶, J. Corpataux⁷, L. Bühler⁸
¹Department of Vascular Surgery, CHUV, Lausannne, Switzerland, ²Department of Surgery, University of California San Francisco, San Francisco, CA, ³Department of Surgery, HUG, Geneva, Switzerland, ⁴Department of Pathology, HUG, Geneva, Switzerland, ⁵Department of Radiology, HUG, Geneva, Switzerland, ⁶Department of Transplantation, CHUV, Lausannne, Switzerland, ⁷Department of Vascular Surgery, CHUV, Lausanne, Switzerland, ⁸Department of Surgery, CHUV, Lausannne, Switzerland
*Purpose: Renal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys.…
2019 American Transplant Congress
Cryopreservation Allows for Extended Graft Survival in a Rat Orthotopic Hind Limb Model
S. A. Fidder¹, B. Oh¹, F. Messner¹, G. Furtmueller¹, K. Helke², E. Greene³, Z. Chen³, L. Campbell³, G. Brandacher¹, K. Brockbank³
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department Of Comparative Medicine, Medical University of South Carolina, Charleston, SC, ³Tissue Testing Technologies LLC, Charleston, SC
*Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for devastating tissue defects. The growth of the field is restrained by the limited ischemia…
2019 American Transplant Congress
First Experience For Cold Storage Of Donor Hearts With Paragonix SherpaPak
L. Stastny¹, M. Kofler¹, D. Höfer¹, G. Pölzl², R. Breitkopf³, M. Grimm¹, H. Antretter¹, J. Dumfarth¹
¹Cardiac Surgery, Medical University Innsbruck, Innsbruck, Austria, ²Internal Medicine, Medical University Innsbruck, Innsbruck, Austria, ³Intensive Care Unit, Medical University Innsbruck, Innsbruck, Austria
*Purpose: Preservation of donor organs is a crucial component for the maintenance of viability after explantation. The current standard for transporting a donor organ includes…
2018 American Transplant Congress
Evaluation of a Marine OXYgen Carrier (Hemo2Life®) for Organ Preservation: First Use in Kidney Transplantation in Humans
Y. Le Meur,¹ E. Morellon,² M. Essig,³ A. Thierry,⁴ M. Buchler,⁵ S. Drouin,⁶ C. Deruelle,¹ L. Badet,² F. Pesteil,³ P-.O. Delpech,⁴ J-.M. Boutin,⁵ B. Barrou.⁶
¹Transplantation, University Hospital, Brest, France; ²Hopital Edouard Herriot, Lyon, France; ³University Hospital, Limoges, France; ⁴University Hospital, Poitiers, France; ⁵University Hospital, Tours, France; ⁶La Pitié Salpetrière, Paris, France.
Preventing ischemia/reperfusion injuries (IRIs) is a major issue in organ transplantation. At present, grafts are preserved at 4[deg]C in preservation solution in order to reduce…

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