2020 American Transplant Congress
Perfusion Regulated Organ Therapeutics with Enhanced Controlled Testing (PROTECT): Novel Human Model to Mitigate Ischemia-Reperfusion Injury in Liver Transplant
Saint Louis University, Saint Louis, MO
*Purpose: Despite a global organ shortage, there is almost a 10% discard rate of ‘marginal donor livers’ (MDL), deemed unsuitable for transplantation due to the…2020 American Transplant Congress
First U.S. DCD Heart Procured/Transplanted after Normothermic Regional Perfusion
*Purpose: We successfully planned, procured and transplanted a heart after a Donation After Cardiac Death (DCD) protocol with post-declaration implementation of in vivo cardiopulmonary bypass…2019 American Transplant Congress
Unsuccessful Resuscitative Thoracotomy Patients Are Potential Kidney Donors
1University of Colorado Hospital, Aurora, CO, 2Denver Health Medical Center, Denver, CO
*Purpose: Renal transplantation remains the most effective therapy in patients with end-stage renal disease, offering exceptional survival benefits and quality of life improvement. However, a…2019 American Transplant Congress
Redox State of HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation
1Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, 2Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor of acute and chronic graft rejection in orthotopic liver transplantation (OLT) involving a complex interplay between…2019 American Transplant Congress
Partial Freezing: Subzero Whole Liver Preservation In The Presence Of Ice
*Purpose: We aim to develop a protocol to bank organs for several days, enabling global organ matching and potentially the utilization of organs unusable with…2019 American Transplant Congress
Normothermic Regional Perfusion of Kidneys: A Single Non-Retrieval Centre Experience
Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom
*Purpose: With the aim of safely expanding the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional (NRP) perfusion…2019 American Transplant Congress
Combined Thoracic-Liver Transplants Using Normothermic Machine Perfusion for Liver Preservation: A Case Series
Henry Ford Transplant Institute, Detroit, MI
*Purpose: There is minimal data describing combined thoracic-liver transplants (tx) with normothermic machine perfusion (NMP) used for liver preservation as the thoracic tx is done.…2019 American Transplant Congress
Brief Normothermic Machine Perfusion is Superior to Cold Storage Alone – A Paired Discarded Human Kidney Analysis
1Westmead Hospital, Sydney, Australia, 2Westmead Institute for Medical Research, Sydney, Australia
*Purpose: The use of marginal has increased due to ongoing donor shortages. These kidneys have higher rates of graft discard after procurement, and also have…2019 American Transplant Congress
CEACAM1 – p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human
1UCLA, Los Angeles, CA, 2City of Hope, Duarte, CA
*Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolism, its role in orthotopic liver transplantation (OLT) is unknown. A recent…2019 American Transplant Congress
Patient Perspectives of Informed Consent for Deceased Donor Organ Intervention Research
*Purpose: Interventions on deceased donors or their organs hold promise for increasing the quantity and quality of organs for transplantation by minimizing organ injury and…
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