2020 American Transplant Congress
The Changes of Transaminases, Lactate Dehydrogenase and pH Levels During Normothermic Liver Preservation Correlate with Early Allograft Dysfunction
*Purpose: Normothermic liver preservation (NMP) has become a clinically established tool to preserve livers in a near-physiological environment. Currently, decreasing lactate and physiological pH-levels are…2020 American Transplant Congress
Abdominal Multiorgan Retrieval from Pigs in a Slaughterhouse: A Reliable and Efficient Donation after Circulatory Death Model for Ex Vivo Organ Perfusion
Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom
*Purpose: Advances in organ perfusion technology have been driven by the increasing necessity to utilise organs from donors after circulatory death (DCD) and marginal donors.…2020 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage: Preliminary Clinical Experience from a Prospective, Multi-Center Randomized Controlled Trial
*Purpose: Hypothermic oxygenated machine perfusion (HMP-O2) is a novel liver preservation technique currently in clinical trials. It has the potential to mitigate ischemia/reperfusion injury, as…2020 American Transplant Congress
Consistent Prevention of Perioperative Cardiac Xenograft Dysfunction with Non-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…2020 American Transplant Congress
Using an Ex Vivo Blood-Free Model of Preservation and Reperfusion to Evaluate the Effects of Subnormothermic Perfusion with Hydrogen Sulfide on DCD Porcine Renal Grafts
*Purpose: The need for donor blood complicates the clinical translation of normothermic and subnormothermic perfusion for preservation and graft function evaluation. As such, hemoglobin-based oxygen…2020 American Transplant Congress
Impact of Liver Graft Preservation Methods on the Gut Microbiome and Metabolome
*Purpose: Normothermic ex-vivo liver perfusion (NEVLP) is a powerful platform for organ preservation and assessment. It induces metabolic reactivation that potentially helps clear accumulated toxic…2020 American Transplant Congress
Metabolism Reprogramming During Conventional versus Ischemia-Free Liver Transplantation
*Purpose: Our group has developed a novel transplant procedure called ischemia-free liver transplantation (IFLT), during which the liver can be procured, preserved and implanted without…2020 American Transplant Congress
First Experience with a New Storage Device for Cold Heart Preservation
Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
*Purpose: The standard technology for heart preservation for transplantation is cold static storange on ice. No temperature control is performed routinley and therefore lower or…2020 American Transplant Congress
Perfusion Regulated Organ Therapeutics with Enhanced Controlled Testing (PROTECT): Novel Human Model to Mitigate Ischemia-Reperfusion Injury in Liver Transplant
Saint Louis University, Saint Louis, MO
*Purpose: Despite a global organ shortage, there is almost a 10% discard rate of ‘marginal donor livers’ (MDL), deemed unsuitable for transplantation due to the…2020 American Transplant Congress
First U.S. DCD Heart Procured/Transplanted after Normothermic Regional Perfusion
*Purpose: We successfully planned, procured and transplanted a heart after a Donation After Cardiac Death (DCD) protocol with post-declaration implementation of in vivo cardiopulmonary bypass…
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