Articles tagged "Preservation"

2020 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage: Preliminary Clinical Experience from a Prospective, Multi-Center Randomized Controlled Trial
G. G. Panayotova¹, R. Quillin III², F. Paterno¹, K. Lunsford¹, M. A. McCarty¹, A. Bailey², G. Dikdan¹, J. Rosado¹, S. Shah², J. V. Guarrera¹
¹Transplant and HPB Surgery, Rutgers NJMS, Newark, NJ, ²Division of Transplantation, University of Cincinnati, Cincinnati, OH
*Purpose: Hypothermic oxygenated machine perfusion (HMP-O2) is a novel liver preservation technique currently in clinical trials. It has the potential to mitigate ischemia/reperfusion injury, as…
2020 American Transplant Congress
Consistent Prevention of Perioperative Cardiac Xenograft Dysfunction with Non-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, P. Odonkor¹, A. Tabatabai¹, A. Bhutta¹, E. Strauss¹, B. Williams¹, D. Ayares², M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
Using an Ex Vivo Blood-Free Model of Preservation and Reperfusion to Evaluate the Effects of Subnormothermic Perfusion with Hydrogen Sulfide on DCD Porcine Renal Grafts
S. Juriasingani¹, A. Ruthirakanthan¹, M. Richard-Mohamed², M. Zhang¹, M. Levine¹, E. Sogutdelen¹, M. Mandurah¹, A. Sener¹
¹University of Western Ontario, London, ON, Canada, ²London Health Sciences Centre, London, ON, Canada
*Purpose: The need for donor blood complicates the clinical translation of normothermic and subnormothermic perfusion for preservation and graft function evaluation. As such, hemoglobin-based oxygen…
2020 American Transplant Congress
Impact of Liver Graft Preservation Methods on the Gut Microbiome and Metabolome
G. A. Cresci¹, N. Sangwan², A. Simioni³, Q. Liu³, C. Quintini³
¹Pediatric Gastroenterology and Inflammation & Immunity, Cleveland Clinic, Cleveland, OH, ²Lerner Research Institute, Cleveland Clinic, Cleveland, OH, ³Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Normothermic ex-vivo liver perfusion (NEVLP) is a powerful platform for organ preservation and assessment. It induces metabolic reactivation that potentially helps clear accumulated toxic…
2020 American Transplant Congress
Metabolism Reprogramming During Conventional versus Ischemia-Free Liver Transplantation
Z. Guo¹, Z. Zhang¹, N. Gao¹, H. Zhang², X. He¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: Our group has developed a novel transplant procedure called ischemia-free liver transplantation (IFLT), during which the liver can be procured, preserved and implanted without…
2020 American Transplant Congress
First Experience with a New Storage Device for Cold Heart Preservation
A. Zuckermann, J. Gökler, P. Kaiser, E. Ceran, N. Neuber, P. Angleitner, G. Laufer, A. Aliabadi-Zuckermann
Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
*Purpose: The standard technology for heart preservation for transplantation is cold static storange on ice. No temperature control is performed routinley and therefore lower or…
2020 American Transplant Congress
Perfusion Regulated Organ Therapeutics with Enhanced Controlled Testing (PROTECT): Novel Human Model to Mitigate Ischemia-Reperfusion Injury in Liver Transplant
M. Nazzal, E. Madsen, M. Nguyen, A. Welu, H. Madnawat, C. Manithody, C. Denton, D. Blackall, D. Carpenter, J. Teckman, C. Varma, A. Jain
Saint Louis University, Saint Louis, MO
*Purpose: Despite a global organ shortage, there is almost a 10% discard rate of ‘marginal donor livers’ (MDL), deemed unsuitable for transplantation due to the…
2020 American Transplant Congress
First U.S. DCD Heart Procured/Transplanted after Normothermic Regional Perfusion
A. L. Friedman¹, Z. N. Kon², D. E. Smith², B. Sullivan³, J. Carillo², N. Moazami²
¹LiveOnNY, New York, NY, ²Cardiothoracic Surgery, NYU Langone Transplant Institute, New York, NY, ³NYU Langone Transplant Institute, New York, NY
*Purpose: We successfully planned, procured and transplanted a heart after a Donation After Cardiac Death (DCD) protocol with post-declaration implementation of in vivo cardiopulmonary bypass…
2020 American Transplant Congress
Making History, Saving Lives: One OPOs Experience Making History by Being the First in the Nation to Successfully Allocate Seven Organs for Transplant from a Donation after Circulatory Death (DCD) Donor
J. B. Nave, A. J. Boyer, C. A. Hostetler, C. C. Muse, R. A. Squires, J. P. Orlowski
LifeShare Transplant Donors Services, Oklahoma City, OK
*Purpose: At the time of this recovery, our OPO’s percentage of DCD donors was 41%. Continuing to maximize the gift successfully by increasing the percentage…
2020 American Transplant Congress
The Impact of Deceased Donor Maintenance on the Incidence of Delayed Kidney Allograft Function
S. Costa¹, F. Barroso¹, C. Oliveira¹, E. Daher¹, P. Fernandes¹, L. Andrade², R. Esmeraldo³, T. Sandes-Freitas¹
¹Universidade Federal do Ceará, Fortaleza, Brazil, ²Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, Brazil, ³Hospital Geral de Fortaleza, Fortaleza, Brazil
*Purpose: To evaluate the risk factors for delayed graft function (DGF) in a Brazilian cohort with high DGF incidence, focusing on variables reflecting donor maintenance.*Methods:…

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