Articles tagged "Preservation"

2021 American Transplant Congress
Impact of Machine Perfusion of the Heart on Abdominal Organ Procurement from Donation After Cardiac Death Donors
C. Feizpour, C. Hwang, A. Shubin, J. Shah, L. DeGregoria, S. Hanish, P. Vagefi, M. MacConmara
Department of Surgery, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Superior preservation with normothermic machine perfusion devices has been demonstrated in thoracic and abdominal allografts, especially DCD donation, where clinical utilization of DCD hearts…
2021 American Transplant Congress
Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial
J. Markmann¹, M. Abouljoud², M. Ghobrial³, C. Bhati⁴, S. Pelletier⁵, J. Magliocca⁶, T. Pruett⁷, A. Lu⁸, M. Rizzari⁹, S. Ottmann¹⁰, T. Klair¹¹, C. Eymard¹², G. Roll¹³, G. Reyes¹⁴, S. Black¹⁵, S. Florman¹⁶, S. Mirani¹⁷, C. Marsh¹⁸, G. Schnickel¹⁹, M. Kinkhabwala²⁰, A. Demetris²¹, H. Yeh²², P. Vagefi²³, M. MacConmara²³
¹MGH, Boston, MA, ²Henry Ford, Detroit, MI, ³Houston Methodist, Houston, TX, ⁴Virginia Commonwealth, Richmond, VA, ⁵UVA, Charlottesville, VA, ⁶Emory, Atlanta, GA, ⁷U. Minnesota, Minneapolis, MN, ⁸Tampa General, Tampa, FL, ⁹Henry Ford, Detriot, MI, ¹⁰Johns Hopkins, Baltimore, MD, ¹¹University of Texas HSC, San Antonio, TX, ¹²University of Tennessee HSC, Memphis, TN, ¹³UCSF, San Francisco, CA, ¹⁴U. Washington, Seattle, WA, ¹⁵Ohio State, Columbus, OH, ¹⁶Mt. Sinai, New York, NY, ¹⁷U. Nebraska, Omaha, NE, ¹⁸Scripps Clinic, San Diego, CA, ¹⁹U. San Diego, San Diego, CA, ²⁰Montefiore, New York, MA, ²¹UPMC, Pittsburgh, PA, ²²Massachusetts General Hospital, Boston, MA, ²³UT Southwestern, Dallas, TX
*Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
2020 American Transplant Congress
Metabolism Reprogramming During Conventional versus Ischemia-Free Liver Transplantation
Z. Guo¹, Z. Zhang¹, N. Gao¹, H. Zhang², X. He¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: Our group has developed a novel transplant procedure called ischemia-free liver transplantation (IFLT), during which the liver can be procured, preserved and implanted without…
2020 American Transplant Congress
First Experience with a New Storage Device for Cold Heart Preservation
A. Zuckermann, J. Gökler, P. Kaiser, E. Ceran, N. Neuber, P. Angleitner, G. Laufer, A. Aliabadi-Zuckermann
Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
*Purpose: The standard technology for heart preservation for transplantation is cold static storange on ice. No temperature control is performed routinley and therefore lower or…
2020 American Transplant Congress
Perfusion Regulated Organ Therapeutics with Enhanced Controlled Testing (PROTECT): Novel Human Model to Mitigate Ischemia-Reperfusion Injury in Liver Transplant
M. Nazzal, E. Madsen, M. Nguyen, A. Welu, H. Madnawat, C. Manithody, C. Denton, D. Blackall, D. Carpenter, J. Teckman, C. Varma, A. Jain
Saint Louis University, Saint Louis, MO
*Purpose: Despite a global organ shortage, there is almost a 10% discard rate of ‘marginal donor livers’ (MDL), deemed unsuitable for transplantation due to the…
2020 American Transplant Congress
First U.S. DCD Heart Procured/Transplanted after Normothermic Regional Perfusion
A. L. Friedman¹, Z. N. Kon², D. E. Smith², B. Sullivan³, J. Carillo², N. Moazami²
¹LiveOnNY, New York, NY, ²Cardiothoracic Surgery, NYU Langone Transplant Institute, New York, NY, ³NYU Langone Transplant Institute, New York, NY
*Purpose: We successfully planned, procured and transplanted a heart after a Donation After Cardiac Death (DCD) protocol with post-declaration implementation of in vivo cardiopulmonary bypass…
2020 American Transplant Congress
Making History, Saving Lives: One OPOs Experience Making History by Being the First in the Nation to Successfully Allocate Seven Organs for Transplant from a Donation after Circulatory Death (DCD) Donor
J. B. Nave, A. J. Boyer, C. A. Hostetler, C. C. Muse, R. A. Squires, J. P. Orlowski
LifeShare Transplant Donors Services, Oklahoma City, OK
*Purpose: At the time of this recovery, our OPO’s percentage of DCD donors was 41%. Continuing to maximize the gift successfully by increasing the percentage…
2020 American Transplant Congress
The Impact of Deceased Donor Maintenance on the Incidence of Delayed Kidney Allograft Function
S. Costa¹, F. Barroso¹, C. Oliveira¹, E. Daher¹, P. Fernandes¹, L. Andrade², R. Esmeraldo³, T. Sandes-Freitas¹
¹Universidade Federal do Ceará, Fortaleza, Brazil, ²Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, Brazil, ³Hospital Geral de Fortaleza, Fortaleza, Brazil
*Purpose: To evaluate the risk factors for delayed graft function (DGF) in a Brazilian cohort with high DGF incidence, focusing on variables reflecting donor maintenance.*Methods:…
2020 American Transplant Congress
The Scenario of Delayed Graft Function in Brazil
T. V. Sandes-Freitas¹, M. Mazzali², R. Manfro³, H. Tedesco-Silva⁴, L. Andrade⁵, V. Garcia⁶, E. Davi-Neto⁷, R. Esmeraldo⁸, C. Oliveira⁹, E. Lasmar¹⁰, R. Madeira¹¹, G. Ferreira¹², G. Meira¹³, F. Cavalcanti¹⁴, A. Bignelli¹⁵, D. Carvalho¹⁶, D. Pedroso¹⁷, L. Deboni¹⁸, A. Silva e Filho¹⁹, A. Vicari³, M. Sousa², .. on behalf of 'DGF multicêntrico' group²⁰
¹Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, Brazil, ²HC/UNICAMP, Campinas, Brazil, ³HCPA/UFRGS, Porto Alegre, Brazil, ⁴Hospital do Rim, São Paulo, Brazil, ⁵HC-Botucatu/UNESP, Botucatu, Brazil, ⁶Santa Casa de Porto Alegre, Porto Alegre, Brazil, ⁷HC/FMUSP, São Paulo, Brazil, ⁸H. Geral de Fortaleza, Fortaleza, Brazil, ⁹HUWC/UFC, Fortaleza, Brazil, ¹⁰H. Universitário São José, Belo Horizonte, Brazil, ¹¹H. Felício Rocho, Belo Horizonte, Brazil, ¹²Santa Casa de Juiz de Fora, Juiz de Fora, Brazil, ¹³Santa Casa de Montes Claros, Montes Claros, Brazil, ¹⁴Real Hospital Português, Recife, Brazil, ¹⁵H. Universitário Cajuru, Curitiba, Brazil, ¹⁶H. São Francisco na Providencia de Deus, Rio de Janeiro, Brazil, ¹⁷H. Santa Isabel, Blumenau, Brazil, ¹⁸H. Municipal São José, Joinville, Brazil, ¹⁹H. Israelita Albert Einstein, São Paulo, Brazil, ²⁰ABTO, São Paulo, Brazil
*Purpose: Unicenter Brazilian studies reported high incidences (50-70%) of delayed graft function (DGF). This is a multicenter Brazilian study aimed to evaluate the incidence, the…
2020 American Transplant Congress
In-Depth Assessment of Ischemia/Reperfusion Injury in a Murine Model of Hindlimb Transplantation
F. Messner¹, K. Kadono², Y. Guo¹, B. Oh¹, J. Kupiec-Weglinski², G. Brandacher¹
¹Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Surgery, Division of Liver and Pancreas Transplantation, University of California, Los Angeles, Los Angeles, CA
*Purpose: Static cold storage (SCS) still represents the gold standard for organ and tissue preservation in transplantation. Ischemia/reperfusion injury (IRI) that occurs due to the…