ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation"

  • 2022 American Transplant Congress

    Regulation of Cell Death During Cold Preservation of Marginal Human Kidneys

    J. R. DiRito1, G. Chickering1, J. Langford1, D. Stern1, D. Qin2, S. Hosgood3, M. Nicholson3, J. Pober4, E. Gavathiotis5, R. Kitsis5, G. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Albert Einstein College of Medicine, Bronx, NY, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Immunology, Yale School of Medicine, New Haven, CT, 5Albert Einstein College of Medicine, Bronx, NM

    *Purpose: Each year thousands of kidneys from marginal donors are discarded due to an increased sensitivity to injury during cold storage and consequently a high…
  • 2022 American Transplant Congress

    Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device

    K. S. Hansen1, R. Meier2, J. Gardner1

    1University of California San Francisco, San Francisco, CA, 2Division of Transplant Surgery, University of Maryland, San Francisco, CA

    *Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
  • 2022 American Transplant Congress

    Novel Portable Hypothermic Cardiac Preservation Device Enhances Cardiac Viability and Function of the Isolated Porcine Hearts

    K. Andrijauskaite, R. J. Veraza, R. P. Lopez, E. C. Cisneros, I. J. Jessop, M. D. Watt, L. Bunegin

    Vascular Perfusion Solutions, Inc, San Antonio, TX

    *Purpose: Cardiac heart transplantation is the gold standard for treating end-stage heart failure; however, the list of patients waiting for heart transplants continues to increase.…
  • 2022 American Transplant Congress

    Analysis of Tissue and Effluent Damage Associated Molecular Patterns Following Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage in Liver Transplantation

    G. G. Panayotova, Y. Qin, S. Simonishvili, T. Ayorinde, F. Paterno, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera

    Transplant Surgery, Rutgers New Jersey Medical School, Newark, NJ

    *Purpose: Hypothermic Oxygenated Machine Perfusion (HMP-O2) results in decreased ischemia/reperfusion injury (IRI) after liver transplantation; however, the molecular pathways of protection are largely unexplored. In…
  • 2022 American Transplant Congress

    Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation

    A. Rossi1, S. Sedrakyan2, F. Montali3, C. Aardena4, N. Abraham5, A. Barbas5, L. N. Byers6, C. Palles7, A. Asthana6, J. Robertson4, L. Perin2, R. Senger4, B. Bussolati1, G. Orlando8

    1Un. of Turin, Turin, Italy, 2Children Hospital, Los Angeles, CA, 3Un. of L'Aquila, L'Aquila, Italy, 4VA Tech, Blacksburg, VA, 5Duke, Durham, NC, 6WFIRM, Winston Salem, NC, 7University of Florida, Gainesville, FL, 8Wake Forest Baptist, Winston-Salem, NC

    *Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
  • 2022 American Transplant Congress

    Donor Macrophage Depletion Improves Kidney Graft Function Despite Long Cold Ischemia

    C. Jordan1, A. Dangi2, X. Luo1

    1Duke University School of Medicine, Durham, NC, 2Medicine, Duke University, Durham, NC

    *Purpose: Prolonged cold ischemia is a known risk factor for delayed graft function and poorer outcomes after kidney transplantation. Overcoming this obstacle is key to…
  • 2022 American Transplant Congress

    Organ Care System Use in Liver Transplantation Shifts Preservation-Reperfusion Injury in Time and Space

    A. J. Demetris, M. A. Wood-Trageser, D. Lesniak, -. The PROTECT Investigators

    Department of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Liver allograft ischemia-reperfusion injury (IRI) causes early allograft dysfunction (EAD). The TransMedics Organ Care System (OCS) PROTECT trial for liver transplantation (NCT02522871) revealed that…
  • 2021 American Transplant Congress

    Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma

    E. Chichelnitskiy1, B. Wiegmann2, N. Ledwoch1, F. Ius2, F. Wandrer1, J. Kühne1, K. Beushausen1, J. Keil1, S. V. Rojas2, W. Sommer2, C. Kühn2, I. Tudorache2, M. Avsar2, A. Haverich2, G. Warnecke2, C. S. Falk1

    1MHH, Institute of Transplant Immunology, Hannover, Germany, 2MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany

    *Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…
  • 2021 American Transplant Congress

    Combined Liver and Lung Transplantation with Extended Normothermic Liver Preservation Using Transmedics Organ Care System (OCS)TM Liver: A Single Center Experience

    J. Konel1, M. Shamaa2, O. Shamaa2, A. Elsabbagh2, T. Kitajima2, T. Ivanics2, K. Delvecchio2, A. Mohamed2, S. Yeddula2, K. Collins2, A. Yoshida2, M. Abouljoud2, S. Nagai2, M. Rizzari2

    1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Transplant Institute, Detroit, MI

    *Purpose: Combined liver-lung transplantation (CLLT) is indicated in patients who cannot survive single-organ transplantation alone. Ex-situ normothermic machine perfusion (NMP) has been used to increase…
  • 2021 American Transplant Congress

    Mitigating the Adverse Impact of Broader Kidney Sharing with Hospital-based Machine Perfusion

    Y. Yushkov, B. R. Schleich, T. Carrea, V. Wadhera, M. J. Goldstein

    Hackensack University Medical Center, Hackensack, NJ

    *Purpose: The new UNOS kidney allocation changes effective December 2020 will be removing the geographic limits of donation service areas (DSA) and UNOS regions favoring…
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