ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation"

  • 2022 American Transplant Congress

    Cold Pulsatile Perfusion of Donor Kidneys Varies Significantly by Procuring Organ Procurement Organization Indicating Both Over and Underutilization of This Preservation Method

    D. S. Keith, E. Lessmann

    Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL

    *Purpose: To assess the usage and variability cold pulsatile perfusion preservation in the United States based on procuring organ procurement organization (OPO).*Methods: All donors procured…
  • 2022 American Transplant Congress

    Deceased Donor Organ Flush with Similar Volumes of HTK and UW at a Single U.S. Organ Procurement Organization: Adult and Pediatric Data

    A. E. Mangus1, C. Kubal2, B. Ekser3, P. Mihaylov4, A. J. Lutz1, J. Fridell5, R. Mangus6

    1Indiana University Purdue University of Indianapolis, Indianapolis, IN, 2Indiana University Hospital, Indianapolis, IN, 3Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, 4Indiana Univ School of Medicine, Indianapolis, IN, 5Indiana University School of Medicine, Indianapolis, IN, 6Indiana University, Indianapolis, IN

    *Purpose: Histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solutions are the two primary solid-organ preservation solutions used in the United States (>95%), but flush volumes…
  • 2022 American Transplant Congress

    Cold Pulsatile Perfusion of Deceased Donor Kidneys Substantially Improves Kidney Utilization of Donors After Cardiac Death and Brain Dead Donors with KDPI Greater Than 60%

    D. S. Keith, E. Lessmann

    Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL

    *Purpose: To determine trends in usage of cold pulsatile kidney perfusion and its impact on organ utilization in the United States using the SRTR database.*Methods:…
  • 2022 American Transplant Congress

    Intraabdominal Hypertension in the Death by Neurologic Criteria Organ Donor

    C. Schardein1, M. Moncure2, S. Craft1, S. Sanders3

    1General Surgery, University of Missouri at Kansas City, Kansas City, MO, 2Trauma and Critical Care Surgery, University of Missouri at Kansas City, Kansas City, MO, 3MTN, Kansas City, MO

    *Purpose: This study attempts to identify the incidence of abdominal compartment syndrome (ACS) within the death by neurological criteria organ donor population, provide timely intervention,…
  • 2022 American Transplant Congress

    Early vs. Late Heparin Administration After Declaration of Death in DCD Donors Does Not Impact Short Term Outcomes in Kidney Transplantation

    A. M. Hawxby, R. Ketcham, R. Squires, J. P. Orlowski, H. Solomon, C. Hostetler

    Organ Recovery, LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK

    *Purpose: Kidneys from Donation after Cardiac Death (DCD) donors are well-known to have satisfactory outcomes post-transplant. In DCD donors, heparin is typically given immediately prior…
  • 2022 American Transplant Congress

    Perfusate Il-6 Levels During Liver Nmp Are Predictive For Hemodynamic Response And Catecholamine Demand After Reperfusion In The Recipient

    A. Weissenbacher1, S. Mathis2, B. Cardini1, C. Bogensperger1, G. Putzer2, L. Gasteiger2, T. Resch1, R. Oberhuber1, D. Öfner1, T. Hell3, J. Martini2, S. Schneeberger1

    1Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria, 2Department of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria, 3Department of Mathematics, Faculty of Mathematics, Computer Science and Physics, University of Innsbruck, Innsbruck, Austria

    *Purpose: Normothermic liver preservation (NMP) has become a clinical routine at several transplant centres. Reperfusion-syndrome occurs less often in recipients of NMP-livers compared to cold…
  • 2022 American Transplant Congress

    Xenogeneic Cross-Circulation Supports Ex Vivo Human Livers for 24 Hours

    W. K. Wu1, R. Ukita2, Y. J. Patel2, I. A. Ziogas3, M. Cortelli2, M. Mentz2, J. R. Talackine2, S. A. Francois2, N. L. Cardwell2, J. W. Stokes2, S. P. Alexopoulos3, M. Bacchetta2

    1Hepatobiliary Surgery and Liver Transplantation; Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, 2Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, 3Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN

    *Purpose: Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a…
  • 2021 American Transplant Congress

    Cross-Circulation for Extracorporeal Liver Support in a Swine Model

    W. K. Wu1, A. Tumen1, J. W. Stokes2, R. Ukita2, A. E. Hozain3, C. R. Flynn2, M. J. Lee3, J. R. Talackine2, N. L. Cardwell2, J. A. Reimer3, M. Pinezich3, C. Benson2, G. Vunjak-Novakovic3, S. P. Alexopoulos2, M. Bacchetta2

    1co-first authors, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Columbia University Medical Center, New York, NY

    *Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
  • 2021 American Transplant Congress

    Successful Long Term Survival of Vascularized Composite Allografts After Extended Preservation at Subzero Temperatures Using Bioinspired Next Generation Cryoprotectants

    M. Kline1, S. Fidder2, A. Callegari1, A. Matoso2, B. Oh2, K. Lombardo2, J. Etra2, D. Vasilic3, A. Childs1, R. Redett2, G. Brandacher2, X. Wei1

    1X-Therma Inc., Richmond, CA, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Erasmus MC, Rotterdam, Netherlands

    *Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for patients with devastating tissue defects. However, the field is constrained by short tolerable ischemia…
  • 2021 American Transplant Congress

    Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys

    J. R. DiRito1, G. Chickering2, J. T. Langford1, D. Stern1, S. Hosgood3, M. L. Nicholson3, E. Gavathiotis4, R. N. Kitsis5, M. Saltzman2, J. S. Pober6, G. T. Tietjen7

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, 5Surgery, Albert Einstein College of Medicine, Bronx, NY, 6Immunobiology, Yale University, New Haven, CT, 7Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT

    *Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
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