ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation"

  • 2016 American Transplant Congress

    Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.

    J. Kox,1 C. Moers,2 D. Monbaliu,3 A. Strelniece,4 J.-W. Treckmann,5 I. Jochmans,3 H. Leuvenink,2 L. van Heurn,1 J. Pirenne,3 A. Paul,5 R. Ploeg.2,6

    1Dept. of Surgery, Maastricht University Medical Center, Maastricht, Netherlands; 2Dept. of Surgery, University Medical Center Groningen, Groningen, Netherlands; 3Abdominal Transplant Surgery, University Hospital Leuven, Leuven, Belgium; 4Eurotransplant, Leiden, Netherlands; 5General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; 6Oxford Transplant Centre, Oxford, United Kingdom.

    IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…
  • 2016 American Transplant Congress

    Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation.

    M. Khan,1 H. El-Hennawy,1 J. Rogers,1 A. Farney,1 G. Orlando,1 A. Reeves-Daniel,2 A. Palanisamy,2 R. Stratta.1

    1Surgery, Wake Forest, Winston-Salem, NC; 2Internal Medicine, Wake Forest, Winston-Salem, NC.

    Proposed changes in pancreas transplant (PT) allocation may improve organ sharing but increase cold ischemia time (CIT). Methods: We performed a single center, retrospective study…
  • 2016 American Transplant Congress

    Ex Vivo Perfusion of Porcine Forelimbs to Prolong Allowable Ischemia Time.

    N. Krezdorn,1 M. Kueckelhaus,2 A. Dermietzel,2 M. Alhefzi,1 M. Aycart,1 S. Fischer,3 T.-S. Win,1 H. Kiwanuka,1 E. Bueno,1 B. Pomahac.1

    1Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Department of Plastic Surgery, Burn Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Bochum, Germany; 3Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany.

    PurposeSuccessful replantation in patients suffering from traumatic amputation of one or more extremities is limited by the muscle ischemia time of 4-6h, which also holds…
  • 2015 American Transplant Congress

    Hypothermic Machine Perfusion Improves the Quality of Marginal Donor Pancreata

    M. Leemkuil,1 M. Engelse,2 R. Ploeg,3 E. de Koning,2 C. Krikke,1 H. Leuvenink.1

    1Surgery, University Medical Center Groningen, Groningen, Netherlands; 2Nephrology, Leiden University Medical Center, Leiden, Netherlands; 3Transplant Biology, Oxford Transplant Center, Oxford, United Kingdom.

    Introduction. Pancreas or islet transplantation is considered the most effective treatment for patients with type 1 diabetes mellitus. Due to the persistent organ shortage, pancreata…
  • 2015 American Transplant Congress

    Lifor Organ Preservation Solution Protects Pulmonary Microvasculature in a Rat Model of Ex Vivo Lung Perfusion and Transplantation

    T. Okamoto,1,3 A. Yasuda,1,2 D. Mathisen,1,3 H. Ott.1,3

    1Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA; 2Department of Anesthesiology, Massachuetts General Hospital, Boston, MA; 3Department of Surgery, Massachuetts General Hospital, Boston, MA.

    A. Ex Vivo Lung Perfusion (EVLP) has emerged as an innovative method for lung preservation. Microvascular dysfunction and breakdown of endothelial barrier during EVLP are…
  • 2015 American Transplant Congress

    Impact of Machine Perfusion After Long Static Cold Storage On Delayed Graft Function Incidence and Duration and Time to Hospital Discharge

    A. Matos,1 M. Borrelli, Jr.,1 L. Moura Requiao,1 M. Nogueira, Jr.,1 L. Pertusier,1 G. Clarizia,1 P. Ongaro,1 S. Ximenes,1 M. Durao, Jr.,1,2 A. Pacheco-Silva.1,2

    1Transplantation, Hospital Israelita Albert Einstein, Sao Paulo, Brazil; 2Medicine/Nephrology, Escola Paulista de Medicina, UNIFESP, Sao Paulo, Brazil.

    Our transplant center is not involved in organ harvesting and usually we receive a kidney for transplant with more then 20 hours of static cold…
  • 2015 American Transplant Congress

    European ELITA ELTR Multicenter Survey On the Management of Bile Duct During Liver Procurement, Preservation and Transplantation

    N. Meurisse,1 D. Monbaliu,1 P. Muiesan,2 A. Pascher,3 M. Oliverius,4 G. Berlakovich,5 R. Adam,6 I. Senesael,1 J. Pirenne.1

    1Abdominal Transplant Surgery Department, University of Leuven, Leuven, Belgium; 2Liver Unit, University of Birmingham, Birmingham, United Kingdom; 3Department of Visceral & Transplantation Surgery, Humboldt University, Berlin, Germany; 4Transplant Surgery Department, IKEM Prague, Prague, Czech Republic; 5Department of Transplant Surgery, Medical University of Vienna, Vienna, Austria; 6Centre Hépato-Biliaire, University Paris Sud, Paris, France.

    Background: Surgical donor/preservation/recipient factors may play a role in the development of biliary strictures. Only scarce data are described on what is the best practice…
  • 2015 American Transplant Congress

    In House Oxygen Persufflation of Cold Stored Livers Versus Simple Cold Storage in Extended Criteria Liver Grafts: Results of a Randomized Controlled Clinical Trial

    A. Gallinat,1 A. Paul,1 D. Hoyer,1 C. Klein,1 S. Swoboda,1 C. Ose,2 Z. Mathe,1 J. Treckmann,1 T. Minor.3

    1Dept. of General-, Viszeral- und Transplantation Surgery, University Hospital Essen, Essen, Germany; 2Institute of Computer Science in Medicine, Biostatistics and Epidemiology, University Hospital Essen, Essen, Germany; 3Surgical Research Div., Universiy Clinic Surgery, Bonn, Germany.

    Two hours of end-ischemic oxygen persufflation of cold stored porcine livers regenerates cellular energy dependent pathways and improves survival after transplantation. The present trial evaluated…
  • 2015 American Transplant Congress

    Correlation Between Level of Biomarkers Measured in Perfusate of Machine-Preserved ECD/DCD Kidneys and Post-Transplant Graft Function

    E. Ablorsu,1 S. Zouwail,2 P. Laftsidis,1 B. Cook,1 L. Szabo.1

    1Cardiff Transplant Unit, University Hospital for Wales, Cardiff, United Kingdom; 2The Medical Biochemistry and Immunology Department, University Hospital for Wales, Cardiff, United Kingdom.

    Background:DCD and ECD kidneys are associated with higher risk of failure compare to SCD kidneys. Therefore we see increasing need to identify sensitive tool to…
  • 2015 American Transplant Congress

    Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia

    D. Aufhauser, Jr.,1 Z. Wang,1 S. Cheraghlou,1 T. Bhatti,2 W. Hancock,2,3 M. Levine.1,4

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA; 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; 3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; 4Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.

    Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
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