ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preservation solutions"

  • 2022 American Transplant Congress

    Impact of Total Parenteral Nutrition on Donor Kidneys During Oxygenated Preservation at 22ºC Ex Vivo

    P. Luke1, A. Jackson2, A. Ruthirakanthan2, S. Juriasingani2, M. Levine1, L. Jiang2, R. Patel2, M. Richard-Mohamed1, S. Forrest1, A. Sener1, R. N. Bhattacharjee1

    1London Health Sciences Centre, London, ON, Canada, 2Western University, London, ON, Canada

    *Purpose: Recent studies have shown that ex vivo preservation at 37 º C can reduce kidney injury compared to current clinical practice. However, to mitigate…
  • 2022 American Transplant Congress

    Regulation of Cell Death During Cold Preservation of Marginal Human Kidneys

    J. R. DiRito1, G. Chickering1, J. Langford1, D. Stern1, D. Qin2, S. Hosgood3, M. Nicholson3, J. Pober4, E. Gavathiotis5, R. Kitsis5, G. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Albert Einstein College of Medicine, Bronx, NY, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Immunology, Yale School of Medicine, New Haven, CT, 5Albert Einstein College of Medicine, Bronx, NM

    *Purpose: Each year thousands of kidneys from marginal donors are discarded due to an increased sensitivity to injury during cold storage and consequently a high…
  • 2022 American Transplant Congress

    Analysis of Antibiotic Resistance and Risk Level of Preservation Fluid Microorganisms in Kidney Transplant Recipients

    J. Li1, X. Su1, J. Han2, Y. Huang2, W. Wu1, M. Wei2, S. Yuan2, C. Wu1, J. Li1, L. Liu1, C. Wang1

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Sun Yat-sen University, Guangzhou, China

    *Purpose: As a solution for preserving kidney during procurement and transportation, preservation fluid (PF) is the main method to detect donor-derived infection. But there are…
  • 2022 American Transplant Congress

    Sigma-1 Receptor Agonists Are Protective in a Rat Model of Kidney Transplantation

    A. Hosszu1, T. Lakat1, A. Toth1, J. Hodrea1, L. Wagner2, A. J. Szabo1, A. Fekete1

    11st Department of Pediatrics, Semmelweis University, Budapest, Hungary, 2Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

    *Purpose: Kidney transplantation (Tx) is associated with better long-term outcomes and quality of life compared to dialysis, but the shortage in donor organs is serious…
  • 2022 American Transplant Congress

    Pretransplant microRNAs in Liver Perfusate Associate with Early Allograft Dysfunction

    E. Bardhi, E. Williams, J. McDaniels, T. Rousselle, V. Mas, D. Maluf

    University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Early allograft dysfunction (EAD) in liver transplantation (LT) is associated with poor long-term graft and patient survival. Prior to LT, while organs are stored…
  • 2021 American Transplant Congress

    The Harmful Effect of Retained Peripheral Cells During Flushing and Static Cold Storage in Rat Liver Normothermic Machine Perfusion

    O. Haque1, C. A. Pendexter2, J. F. Markmann2, K. Uygun2, H. Yeh2, S. N. Tessier2

    1Surgery, Beth Israel Deaconess Medical Center, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Retained donor blood in a liver graft can cause damage to resident cells that is exacerbated by static cold storage (SCS), leading to platelet…
  • 2021 American Transplant Congress

    Sigma-1 Receptor Agonists are Renoprotective in Experimental Kidney Transplantation

    A. Hosszu1, T. Lakat1, A. Toth1, D. Balogh1, J. Hodrea1, L. J. Wagner2, A. J. Szabo1, A. Fekete1

    11st Department of Pediatrics, Semmelweis University, Budapest, Hungary, 2Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

    *Purpose: Kidney transplantation (Tx) is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a…
  • 2021 American Transplant Congress

    Combined Liver and Lung Transplantation with Extended Normothermic Liver Preservation Using Transmedics Organ Care System (OCS)TM Liver: A Single Center Experience

    J. Konel1, M. Shamaa2, O. Shamaa2, A. Elsabbagh2, T. Kitajima2, T. Ivanics2, K. Delvecchio2, A. Mohamed2, S. Yeddula2, K. Collins2, A. Yoshida2, M. Abouljoud2, S. Nagai2, M. Rizzari2

    1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Transplant Institute, Detroit, MI

    *Purpose: Combined liver-lung transplantation (CLLT) is indicated in patients who cannot survive single-organ transplantation alone. Ex-situ normothermic machine perfusion (NMP) has been used to increase…
  • 2021 American Transplant Congress

    Feasibility of Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results

    L. I. Mazilescu1, P. Urbanellis1, J. S. Kim1, A. Konvalinka1, T. W. Reichman1, L. A. Robinson2, A. Ghanekar1, M. Selzner1

    1Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: Normothermic ex vivo kidney perfusion is a novel preservation technique with promising results in porcine models and initial clinical results in one European center.…
  • 2020 American Transplant Congress

    The Effect of Pulsatile Pump Perfusion on Hepatitis C Viremia and Transmission in Kidney Transplantation: A Prospective Pilot Study

    R. Forbes1, B. Concepcion1, D. Clapper2, B. Dubray1, A. Miller2, D. Shaffer1, K. Johnson2

    1Vanderbilt University Medical Center, Nashville, TN, 2Tennessee Donor Services, Nashville, TN

    *Purpose: With increasing utilization of hepatitis C (HCV) viremic donor organs for aviremic recipients, there may be a role for kidney pulsatile pump perfusion to…
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