Articles tagged "Preservation"

2022 American Transplant Congress
Evaluation of UW-Based Solutions Formulated to Be Anti-Apoptotic and Neuroprotective of Retinal Ganglion Cells (RGCs) Following Whole Eye Transplantation (WET) in a Rat Model
N. J. Khatter¹, Y. Wang¹, B. Li¹, C. R. Owens¹, A. H. Jani², C. A. Huang¹, R. W. Nickells³, A. A. Su¹, K. M. Washington¹
¹Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO, ²Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, ³Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI
*Purpose: As vascularized composite allotransplantation (VCA) of an intact optical system to restore vision requires overcoming RGC apoptosis caused by ischemia reperfusion injury, UW and…
2022 American Transplant Congress
Regulation of Cell Death During Cold Preservation of Marginal Human Kidneys
J. R. DiRito¹, G. Chickering¹, J. Langford¹, D. Stern¹, D. Qin², S. Hosgood³, M. Nicholson³, J. Pober⁴, E. Gavathiotis⁵, R. Kitsis⁵, G. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Albert Einstein College of Medicine, Bronx, NY, ³Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Immunology, Yale School of Medicine, New Haven, CT, ⁵Albert Einstein College of Medicine, Bronx, NM
*Purpose: Each year thousands of kidneys from marginal donors are discarded due to an increased sensitivity to injury during cold storage and consequently a high…
2022 American Transplant Congress
Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device
K. S. Hansen¹, R. Meier², J. Gardner¹
¹University of California San Francisco, San Francisco, CA, ²Division of Transplant Surgery, University of Maryland, San Francisco, CA
*Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
2022 American Transplant Congress
Novel Portable Hypothermic Cardiac Preservation Device Enhances Cardiac Viability and Function of the Isolated Porcine Hearts
K. Andrijauskaite, R. J. Veraza, R. P. Lopez, E. C. Cisneros, I. J. Jessop, M. D. Watt, L. Bunegin
Vascular Perfusion Solutions, Inc, San Antonio, TX
*Purpose: Cardiac heart transplantation is the gold standard for treating end-stage heart failure; however, the list of patients waiting for heart transplants continues to increase.…
2022 American Transplant Congress
Analysis of Tissue and Effluent Damage Associated Molecular Patterns Following Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage in Liver Transplantation
G. G. Panayotova, Y. Qin, S. Simonishvili, T. Ayorinde, F. Paterno, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera
Transplant Surgery, Rutgers New Jersey Medical School, Newark, NJ
*Purpose: Hypothermic Oxygenated Machine Perfusion (HMP-O2) results in decreased ischemia/reperfusion injury (IRI) after liver transplantation; however, the molecular pathways of protection are largely unexplored. In…
2022 American Transplant Congress
Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation
A. Rossi¹, S. Sedrakyan², F. Montali³, C. Aardena⁴, N. Abraham⁵, A. Barbas⁵, L. N. Byers⁶, C. Palles⁷, A. Asthana⁶, J. Robertson⁴, L. Perin², R. Senger⁴, B. Bussolati¹, G. Orlando⁸
¹Un. of Turin, Turin, Italy, ²Children Hospital, Los Angeles, CA, ³Un. of L'Aquila, L'Aquila, Italy, ⁴VA Tech, Blacksburg, VA, ⁵Duke, Durham, NC, ⁶WFIRM, Winston Salem, NC, ⁷University of Florida, Gainesville, FL, ⁸Wake Forest Baptist, Winston-Salem, NC
*Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
2022 American Transplant Congress
Donor Macrophage Depletion Improves Kidney Graft Function Despite Long Cold Ischemia
C. Jordan¹, A. Dangi², X. Luo¹
¹Duke University School of Medicine, Durham, NC, ²Medicine, Duke University, Durham, NC
*Purpose: Prolonged cold ischemia is a known risk factor for delayed graft function and poorer outcomes after kidney transplantation. Overcoming this obstacle is key to…
2022 American Transplant Congress
Organ Care System Use in Liver Transplantation Shifts Preservation-Reperfusion Injury in Time and Space
A. J. Demetris, M. A. Wood-Trageser, D. Lesniak, -. The PROTECT Investigators
Department of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Liver allograft ischemia-reperfusion injury (IRI) causes early allograft dysfunction (EAD). The TransMedics Organ Care System (OCS) PROTECT trial for liver transplantation (NCT02522871) revealed that…
2022 American Transplant Congress
Duration of Brain Death Does Not Impact Short Term Outcomes in Kidney Transplantation
A. M. Hawxby¹, R. Ketcham², J. P. Orlowski³, R. A. Squires², C. Hostetler²
¹Organ Recovery, LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK, ²LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK, ³LifeShare Transplant Donors Services, Oklahoma City, OK
*Purpose: In animal models, brain death has been shown to induce renal injury, primarily due to ischemia, inflammation, and alterations in hemodynamics. However, donor management…
2022 American Transplant Congress
Vitrification of Pancreatic Islets and Transplantation
J. S. Rao¹, L. Zhan¹, D. Tobolt¹, M. Q. Slama², N. Sethia¹, Z. Han¹, C. S. Dutcher¹, Q. Peterson², J. C. Bischof¹, E. B. Finger¹
¹University of Minnesota, Minneapolis, MN, ²Mayo Clinic, Rochester, MN
*Purpose: A limitation to potential cure for diabetes through islet transplantation is insufficient islet equivalence (IEQ) from a single donor to achieve insulin independence in…

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