Articles tagged "Prediction models"

2015 American Transplant Congress
Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus
P. Chhabra,¹ A. Spano,² D. Bowers,¹ M. Wu,² L. Langman,¹ M. Timko,² K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Biology, University of Virginia, Charlottesville, VA.
Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…
2015 American Transplant Congress
Association Between the Timed Up and Go Test and Waitlisting for Kidney Transplantation
M. Chiles,¹ K. Foley,¹ R. Crew,¹ G. Dube,¹ H. Morris,¹ S. Patel,² J. Camacho,² D. Cohen,¹ L. Ratner,² S. Mohan.¹
¹Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY; ²Department of Surgery, Columbia University College of Physicians & Surgeons, New York, NY.
Introduction: The Timed Up and Go Test (TUGT) is a test of balance, mobility and functional capacity. Longer times on the TUGT are associated with…
2015 American Transplant Congress
The Donor Risk Index Does Not Accurately Classify Patients With or Without Graft Failure
E. Franco,¹ T. Athanasios,² N. Kemmer,³ L. Leone,¹ A. Alsina,¹ B. Djulbegovic.²
¹Surgery, TGMG/USF Morsani College of Medicine, Tampa, FL; ²Internal Medicine, Morsani College of Medicine, USF, Morsani College of Medicine, Tampa, FL; ³Hepatology, TGMG/USF Morsani College of Medicine, Tampa, FL.
In liver transplantation assessing risk of donor is paramount to graft survival. The donor risk index (DRI) was introduced as a predictor of graft failure…
2015 American Transplant Congress
Phenotypic Personalized Medicine: Mechanism-Independent Convergence Into Target Serum Tacrolimus Levels for Optimized Liver Transplant Immunosuppression
A. Zarrinpar,¹ A. Silva,² D.-K. Lee,³ N. Datta,¹ C.-M. Ho,² D. Ho.³
¹Surgery-Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA; ²Mechanical Engineering, UCLA, Los Angeles, CA; ³Bioengineering, and Oral Biology and Medicine, UCLA, Los Angeles, CA.
PURPOSE:Immunosuppressive drugs such as tacrolimus have narrow therapeutic ranges and their dosing variability necessitates intensive drug monitoring. This study aimed to use Feedback System Control…
2015 American Transplant Congress
The Potential Use of the Plasma Biomarker CXCL9 (MIG), Interleukin 2 Receptor alpha (IL2Rα) and SCGF-b as Predictors of Renal Graft Rejection
C. Blume,¹ S. Michael,² N. Christine,³ H. Hermann,⁴ F. Christine.³
¹Technical Chemistry, Leibniz University, Hannover, Germany; ²Musculo Sceletal Reserach, University of Wuerzburg, Wuerzburg, Germany; ³Transplant Immunology, Medical School Hannover, Hannover, Germany; ⁴Dept. Nephrology, Medical School Hannover, Hannover, Germany.
Background: Early detection of rejection in kidney transplantation is crucial, and predictive plasma biomarkers are highly desirable as non-invasive tests.Methods: From a cohort of 120…
2015 American Transplant Congress
The Impact of Critical Illness and Pre-Transplant Hospitalization on Cost of Liver Transplantation
S. Knechtle, L. Brummett, S. Perez.
Surgery, Emory University School of Medicine, Atlanta, GA.
In order to understand the cost impact of hospitalization and ICU admission immediately prior to liver transplantation (LT), we obtained all hospital costs associated with…
2015 American Transplant Congress
Prediction of Acute Antibody Mediated Rejection in Antibody Incompatible Renal Transplantation Using Machine Learning for Wide Data
T. Shaikhina,¹ N. Khovanova,¹ S. Daga,^1,3 N. Krishnan,² D. Lowe,³ D. Mitchell,¹ D. Briggs,² R. Higgins.³
¹University of Warwick, Coventry, United Kingdom; ²NHS Blood and Transplant, Birmingham, United Kingdom; ³University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.
The dynamic field of renal transplantation is characterised by limited access to data, the high cost of equipment and underlying complexity of immunological responses to…
2015 American Transplant Congress
MELD Velocity – An Early Predictor of Increased Mortality Risk
D. Ladner,¹ K. Skibba,² J. Kang,¹ B. Ho,¹ A. Kho,¹ L. Kulik,¹ A. Daud,¹ M. Abecassis,¹ A. Skaro.¹
¹Northwestern University, Chicago, IL; ²Rosalind Franklin University of Medicine and Science, Chicago, IL.
INTRODUCTION: MELD is a satisfactory predictor of 3-month mortality in patients with cirrhosis. However, sub-populations of patients at increased hazard of mortality, but not well…
2015 American Transplant Congress
Multicenter Study to Develop a Novel Prediction Index for Hepatocellular Carcinoma (HCC) Recurrence After Liver Transplant (LT)
N. Mehta,¹ J. Heimbach,² D. Harnois,³ J. Dodge,¹ J. Burns,³ D. Lee,³ W. Sanchez,² J. Roberts,¹ F. Yao.¹
¹UCSF, San Francisco, CA; ²Mayo Clinic, Rochester, MN; ³Mayo Clinic, Jacksonville, FL.
Several factors have been associated with a high risk of recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT), but no reliable risk score has…
2015 American Transplant Congress
External Validation of Clinical Prediction Models of Patient and Graft Survival in a Canadian Cohort of Kidney Transplant Recipients
S. Singh,^1,2 D. Naimark,^1,2,3 J. Victor,² J. Kim.^1,2,4,5
¹Division of Nephrology, Department of Medicine, University of Toronto, Toronto, ON, Canada; ²Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; ³Division of Nephrology, Sunnybrook Health Sciences Center, Toronto, ON, Canada; ⁴Division of Nephrology and the Kidney Transplant Program, University Health Network, Toronto, ON, Canada; ⁵Division of Nephrology and the Renal Transplant Program, St. Michael's Hospital, Toronto, ON, Canada.
Background: Several clinical prediction models (CPM) of patient and graft survival in kidney transplant recipients have been developed as tools to assist physicians in identifying…