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Articles tagged "Prediction models"

  • 2015 American Transplant Congress

    A Relative Survival Model to Compare the Risk of Mortality in Patients Awaiting Kidney Transplantation Versus Already Transplanted Patients

    M. Lorent,1,2 K. Trébern-Launay,2,1 C. Legendre,4 H. Kreis,4 G. Mourad,5 V. Garrigue,5 L. Rostaing,6 N. Kamar,6 M. Kessler,7 M. Ladrière,7 E. Morelon,8 F. Buron,8 M. Giral,2,3 Y. Foucher.1,2

    1EA 4275 - SPHERE bioStatistics, Pharmacoepidemiology and Human Sciences Research, Nantes University, Nantes, France; 2Institut de Transplantation, Urologie, Néphrologie (ITUN), Inserm U1064, CHU de Nantes, Nantes, France; 3CIC Biotherapy, CHU Nantes, Nantes, France; 4Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, APHP Paris, Paris, France; 5Service de Néphrologie-Transplantation, Hôpital Lapeyronie, Montpellier, France; 6Service de Néphrologie, HTA, Dialyse et Transplantation d'Organes, CHU Rangueil, Toulouse, France; 7Service de Transplantation Rénale, CHU Brabois, Nancy, France; 8Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France.

    Introduction: It would be useful for physicians in some specific cases to identify whom patients could not benefit of kidney transplantations.Patients and method: To answer…
  • 2015 American Transplant Congress

    Kidney Allocation Tool of the Future: The Estimated Post-Transplant Survival (EPTS) Score

    M. Moss, M. Gillespie, T. Sparkes, B. Ravichandran, R. Ugarte, A. Haririan.

    University of Maryland, Baltimore.

    Background:Beginning December 2014, a new kidney transplant allocation system will be used. A component of this system is the Estimated Post-Transplant Survival (EPTS) score, which…
  • 2015 American Transplant Congress

    Predicting Obstructive Coronary Artery Disease in Asymptomatic Renal Patients Undergoing Renal Transplantation

    D.-A. Moutzouris, C. Baker, A. Malaweera, M. Willicombe, R. Corbett, N. Duncan, J. Galliford, A. McLean, D. Taube.

    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom.

    Almost 50% of asymptomatic patients with End Stage Renal Disease (ESRD) are reported to have significant flow-limiting coronary artery disease (CAD). Our practice involves a…
  • 2015 American Transplant Congress

    Hospital Characteristics Mediate Variation in Cirrhosis Mortality in Transplant and Non-Transplant Facilities

    A. Mathur,1 A. Chakrabarti,2 K. Sheetz,2 J. Mellinger,3 M. Volk,3 N. Katariya,1 A. Singer,1 W. Hewitt,1 K. Reddy,1 A. Moss.1

    1Surgery, Mayo Clinic Arizona, Phoenix, AZ; 2Surgery, University of Michigan, Ann Arbor, MI; 3Medicine, University of Michigan, Ann Arbor, MI.

    Hospitals vary significantly in cirrhosis mortality. We aimed to determine whether hospital structural characteristics mediate this effect.Methods: We used 2009 data from the HCUP Nationwide…
  • 2015 American Transplant Congress

    Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus

    P. Chhabra,1 A. Spano,2 D. Bowers,1 M. Wu,2 L. Langman,1 M. Timko,2 K. Brayman.1

    1Department of Surgery, University of Virginia, Charlottesville, VA; 2Department of Biology, University of Virginia, Charlottesville, VA.

    Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…
  • 2015 American Transplant Congress

    Association Between the Timed Up and Go Test and Waitlisting for Kidney Transplantation

    M. Chiles,1 K. Foley,1 R. Crew,1 G. Dube,1 H. Morris,1 S. Patel,2 J. Camacho,2 D. Cohen,1 L. Ratner,2 S. Mohan.1

    1Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY; 2Department of Surgery, Columbia University College of Physicians & Surgeons, New York, NY.

    Introduction: The Timed Up and Go Test (TUGT) is a test of balance, mobility and functional capacity. Longer times on the TUGT are associated with…
  • 2015 American Transplant Congress

    The Donor Risk Index Does Not Accurately Classify Patients With or Without Graft Failure

    E. Franco,1 T. Athanasios,2 N. Kemmer,3 L. Leone,1 A. Alsina,1 B. Djulbegovic.2

    1Surgery, TGMG/USF Morsani College of Medicine, Tampa, FL; 2Internal Medicine, Morsani College of Medicine, USF, Morsani College of Medicine, Tampa, FL; 3Hepatology, TGMG/USF Morsani College of Medicine, Tampa, FL.

    In liver transplantation assessing risk of donor is paramount to graft survival. The donor risk index (DRI) was introduced as a predictor of graft failure…
  • 2015 American Transplant Congress

    Phenotypic Personalized Medicine: Mechanism-Independent Convergence Into Target Serum Tacrolimus Levels for Optimized Liver Transplant Immunosuppression

    A. Zarrinpar,1 A. Silva,2 D.-K. Lee,3 N. Datta,1 C.-M. Ho,2 D. Ho.3

    1Surgery-Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA; 2Mechanical Engineering, UCLA, Los Angeles, CA; 3Bioengineering, and Oral Biology and Medicine, UCLA, Los Angeles, CA.

    PURPOSE:Immunosuppressive drugs such as tacrolimus have narrow therapeutic ranges and their dosing variability necessitates intensive drug monitoring. This study aimed to use Feedback System Control…
  • 2015 American Transplant Congress

    The Potential Use of the Plasma Biomarker CXCL9 (MIG), Interleukin 2 Receptor alpha (IL2Rα) and SCGF-b as Predictors of Renal Graft Rejection

    C. Blume,1 S. Michael,2 N. Christine,3 H. Hermann,4 F. Christine.3

    1Technical Chemistry, Leibniz University, Hannover, Germany; 2Musculo Sceletal Reserach, University of Wuerzburg, Wuerzburg, Germany; 3Transplant Immunology, Medical School Hannover, Hannover, Germany; 4Dept. Nephrology, Medical School Hannover, Hannover, Germany.

    Background: Early detection of rejection in kidney transplantation is crucial, and predictive plasma biomarkers are highly desirable as non-invasive tests.Methods: From a cohort of 120…
  • 2015 American Transplant Congress

    The Impact of Critical Illness and Pre-Transplant Hospitalization on Cost of Liver Transplantation

    S. Knechtle, L. Brummett, S. Perez.

    Surgery, Emory University School of Medicine, Atlanta, GA.

    In order to understand the cost impact of hospitalization and ICU admission immediately prior to liver transplantation (LT), we obtained all hospital costs associated with…
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