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Articles tagged "Prediction models"

  • 2017 American Transplant Congress

    A Novel 3-Dimensional Culture System Enables In Vitro Study of Human Bone Marrow Plasma Cells.

    J. Driscoll,1 S. Tremblay,2 S. Knechtle,3 E. Woodle.2

    1Medicine, Univ Cincinnati, Cincinnati, OH; 2Surgery, Univ Cincinnati, Cincinnati, OH; 3Transplant, Duke Univ, Durham, NC

    Purpose: Historically, in vitro study of human plasma cells (PCs) has been greatly limited by their short survival (48-72 hrs). Therefore, systems that maintain viability…
  • 2017 American Transplant Congress

    Shared Decision Aid to Decipher Long-Term Treatment Risks for End Stage Renal Disease Patients.

    J. Gander, A. Manatunga, K. Jacob Arriola, S. Pastan, R. Patzer.

    Emory University, Atlanta, GA

    Kidney transplantation is the preferred treatment for end stage renal disease (ESRD) compared to dialysis. The incidence of ESRD continues to increase while the gap…
  • 2017 American Transplant Congress

    Composite Prognostic Score Improves Clinical Benefit in Kidney Recipients Receiving Standard of Care Therapy for Antibody-Mediated Rejection.

    D. Viglietti, A. Loupy, O. Aubert, E. Pillebout, C. Legendre, D. Glotz, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France

    There is a marked heterogeneity in AMR patients' prognosis after SOC treatment including plasma exchange (PE) and intravenous immunoglobulins (IVIG). We investigated whether the use…
  • 2017 American Transplant Congress

    Risk Prediction Models for Living Donor Kidney Transplantation to Predict Donor and Recipient Mortality and Graft Loss.

    M. Haller,1 G. Mjøen,2 H. Holdaas,3 G. Heinze,4 R. Oberbauer.5

    1Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Vienna, Austria; 2Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway; 3Department of Medicine, Medical University of Vienna, Vienna, Austria

    The purpose of this study was to develop linked risk prediction models for potential donors for and their respective recipients of a kidney transplantation at…
  • 2017 American Transplant Congress

    How Much Is a Kidney Worth? Comparing Kidney Transplant Strategies in Liver Transplant Candidates.

    X. Cheng,1 W. Kim,2 J. Tan,1 J. Goldhaber-Fiebert.3

    1Div Nephrology, ; 2Div Gastroenterology & Hepatology, ; 3Ctr Health Policy, Stanford U, Palo Alto

    The number of simultaneous liver-kidney (SLK) transplants for renal failure complicating end-stage liver disease (ESLD) is rising. The Organ Procurement and Transplant Network (OPTN) will…
  • 2017 American Transplant Congress

    Screening and Referral of High Risk Liver Transplant Recipients to a Transitional Care Coordination (TCC) Program to Reduce Hospital Readmissions.

    A. Masoumi,1 J. Krzyzewski,1 T. Stern,1 N. Schluterman,2 D. Bruno,2 J. Bromberg,2 R. Barth,2 S. Hanish.2

    1University of Maryland Medical Center, Baltimore, MD; 2University of Maryland School of Medicine, Baltimore, MD

    Introduction One-fifth of Medicare patients are readmitted to the hospital. The readmission rate among liver transplant recipients at a large tertiary academic medical center in…
  • 2017 American Transplant Congress

    Maximizing the Potential of Treg-Based Therapies for Transplant Rejection via Computational Immune-Modeling: Effect of Dose, Timing, and Distribution.

    G. Raimondi,1 A. Arun,1 O. Dorabiala,2 J. Arciero.3

    1Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; 2Mathematics, Pennsylvania State University, Philadelphia; 3Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis

    Purpose. Regulatory T cells (Treg), endogenous regulators of the immune system, have a significant therapeutic potential for prevention of transplant rejection. Experimental evidences however, indicate…
  • 2017 American Transplant Congress

    A Markov Model for Transplant & Renal Outcomes After Liver & Simultaneous Liver-Kidney Transplants.

    X. Cheng,1 W. Kim,2 J. Tan,1 J. Goldhaber-Fiebert.3

    1Div Nephrology, Stanford U, Palo Alto; 2Div Gastroenterology & Hepatology, Stanford U, Palo Alto; 3Ctr Health Policy, Stanford U, Palo Alto

    The Organ Procurement and Transplant Network (OPTN) will implement a set of clinical criteria for simultaneous liver-kidney (SLK) transplant eligibility. Our aim is to build…
  • 2017 American Transplant Congress

    A Multidimensional Prognostic Score and Nomogram to Predict Kidney Transplant Survival: The Integrative Box (iBox) System.

    A. Loupy,1 O. Aubert,1 B. Orandi,2 A. Jackson,2 M. Naesens,3 N. Kamar,1 O. Thaunat,1 E. Morelon,1 M. Delahousse,1 D. Viglietti,1 D. Glotz,1 C. Legendre,1 X. Jouven,1 R. Montgomery,2 M. Stegall,4 D. Segev,2 C. Lefaucheur.1

    1Paris Translational Research Center for Organ Transplantation, Paris, France; 2Johns-Hopkins, Baltimore; 3Leuven University, Leuven, Belgium; 4Mayo Clinic, Rochester

    The transplant field currently lacks of robust risk stratification models leading to major problems for clinical care, clinical trials, and medical progress. The goal of…
  • 2017 American Transplant Congress

    Improved Outcome of Kidney Transplants by Donor Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes.

    O. Staeck,1 M. Niemann,4 F. Halleck,1 D. Khadzhynov,1 C. Schönemann,2 P. Reinke,1 E. Spierings,3 K. Budde,1 N. Lachmann.2

    1Nephrology, Charité Universitaetsmedizin, Berlin, Germany; 2HLA Laboratory, Charité Universitaetsmedizin, Berlin, Germany; 3Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands; 4PIRCHE, Berlin, Germany

    Introduction: De novo donor-specific HLA antibodies (dnDSA) are recognized as a risk factor for graft loss. Determinants of DSA specificity are generated via the indirect…
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