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Articles tagged "Prediction models"

  • 2017 American Transplant Congress

    Prediction of Evolution Toward Brain Death in Acute Neurocritical Patients Identified as Potential Organ Donors.

    G. Xu, P. Xu, Z. Guo, X. He.

    Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, Ecuador; Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

    Objective: Reliable prediction of brain death (BD) is of specific interest for organ donation after brain death(DBD). We sought to establish a score based on…
  • 2017 American Transplant Congress

    Decision Tree Analysis of Renal Transplantation Recipients Outcomes: A Single Center Data Mining in the Big Data Era.

    J. Zhou,1 Y. Shen,2 R. Wang,1 H. Huang,1 J. Wu,1 J. Chen.1

    1Kidney Disease Center, the First Affiliated Hospital, Zhejiang University, Hangzhou, China; 2Department of Epidemiology, College of Medicine, Zhejiang University, Hangzhou, China

    Background This is the era of big data and it may help manage clinical practice better. Decision tree analysis is a useful data mining tool…
  • 2017 American Transplant Congress

    Insulin Therapy in Pancreas Donors as a Predictor of Subsequent Transplant Outcome.

    I. Shapey,1 H. Khambalia,2 A. Summers,2 T. Augustine,2 M. Rutter,1 D. van Dellen.1

    1Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, United Kingdom; 2Department of Renal and Pancreas Transplantation, Central Manchester University Hospitals, Manchester, United Kingdom

    Introduction: Brain stem death causes high levels of systemic catecholamines and inflammation affecting all organs. These changes, and the routine use of high-dose corticosteroids in…
  • 2017 American Transplant Congress

    The Association of Donor Vasoactive Drugs with Pancreas Transplant Graft Survival.

    I. Shapey,1 P. Yianoullou,2 A. Summers,2 T. Augustine,2 M. Rutter,1 D. van Dellen.2

    1Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, United Kingdom; 2Department of Renal and Pancreas Transplantation, Central Manchester University Hospitals, Manchester, United Kingdom

    Introduction: Vasoactive drugs (VaD) are commonly used to correct abnormal haemodynamics of organ donors in Intensive Care Units (ICU). VaDs can differentially affect insulin secretion…
  • 2017 American Transplant Congress

    Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.

    P. Saravanan,1 J. Gu,1 X. Wang,1 P. Nguyen,1 G. Yoshimatsu,1 M. Lawrence,1 B. Naziruddin.2

    1Baylor Scott and White Research Institute, Dallas, TX; 2Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…
  • 2017 American Transplant Congress

    A Novel, Dose-Adjusted Tacrolimus Trough Concentration (TTC) Model for Prediction and Variance Estimation.

    J. Kim,1 S. Wilson,1 N. Undre,2 S. Fei,1 R. Kristy,1 J. Schwartz.1

    1Astellas Pharma Global Development, Inc., Northbrook, IL; 2Astellas Pharma Global Development, Inc., Chertsey, United Kingdom

    Given that a high tacrolimus (tac) intrapatient variability (IPV) increases the risk for a poor kidney transplant (tx) outcome, some experts advocate routine IPV monitoring…
  • 2017 American Transplant Congress

    A Novel 3-Dimensional Culture System Enables In Vitro Study of Human Bone Marrow Plasma Cells.

    J. Driscoll,1 S. Tremblay,2 S. Knechtle,3 E. Woodle.2

    1Medicine, Univ Cincinnati, Cincinnati, OH; 2Surgery, Univ Cincinnati, Cincinnati, OH; 3Transplant, Duke Univ, Durham, NC

    Purpose: Historically, in vitro study of human plasma cells (PCs) has been greatly limited by their short survival (48-72 hrs). Therefore, systems that maintain viability…
  • 2017 American Transplant Congress

    Shared Decision Aid to Decipher Long-Term Treatment Risks for End Stage Renal Disease Patients.

    J. Gander, A. Manatunga, K. Jacob Arriola, S. Pastan, R. Patzer.

    Emory University, Atlanta, GA

    Kidney transplantation is the preferred treatment for end stage renal disease (ESRD) compared to dialysis. The incidence of ESRD continues to increase while the gap…
  • 2017 American Transplant Congress

    Composite Prognostic Score Improves Clinical Benefit in Kidney Recipients Receiving Standard of Care Therapy for Antibody-Mediated Rejection.

    D. Viglietti, A. Loupy, O. Aubert, E. Pillebout, C. Legendre, D. Glotz, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France

    There is a marked heterogeneity in AMR patients' prognosis after SOC treatment including plasma exchange (PE) and intravenous immunoglobulins (IVIG). We investigated whether the use…
  • 2017 American Transplant Congress

    Risk Prediction Models for Living Donor Kidney Transplantation to Predict Donor and Recipient Mortality and Graft Loss.

    M. Haller,1 G. Mjøen,2 H. Holdaas,3 G. Heinze,4 R. Oberbauer.5

    1Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Vienna, Austria; 2Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway; 3Department of Medicine, Medical University of Vienna, Vienna, Austria

    The purpose of this study was to develop linked risk prediction models for potential donors for and their respective recipients of a kidney transplantation at…
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