Articles tagged "Prediction models"

2018 American Transplant Congress
A Novel Score for Predicting Mortality and Graft Failure after Kidney Transplant
C. Parsons, F. Shamoun, S. Patel, S. Cha, R. Heilman, M. Keddis.
Mayo Clinic, Scottsdale.
Purpose:To develop a novel score for predicting mortality and graft failure after kidney transplant.Methods:We reviewed a cohort of 783 kidney transplant recipients and analyzed pertinent…
2018 American Transplant Congress
A Novel, Dose-Adjusted Tacrolimus Intrapatient Variability Model Identifies High-Risk Kidney Transplant Recipients Better Than Existing Methodologies
J. Kim, S. Wilson, Y. Song, J. Schwartz.
Astellas Pharma Global Development, Inc., Northbrook.
Intrapatient variability (IPV) of tacrolimus trough concentration (TTC) is a risk factor for inferior transplant outcomes. However, assessing IPV is problematic, relying on fixed dose…
2018 American Transplant Congress
The Predictive Power of MELD is Decreasing in the Era of Older, Sicker Patients
E. Godfrey,¹ J. Lai,² T. Miloh,³ N. Galvan,¹ R. Cotton,¹ C. O'Mahony,¹ J. Vierling,¹ N. Sussman,¹ A. Rana.¹
¹Department of Surgery, Baylor College of Medicine, Houston, TX; ²Department of Medicine, University of California, San Francisco, San Francisco, CA; ³Department of Pediatrics, Baylor College of Medicine, Houston, TX.
PurposeThe field of liver transplantation has shifted considerably in the MELD era. Liver allocation, immunosuppression, and etiologies of liver failure have changed over time, and…
2018 American Transplant Congress
Maximizing Utilization in Pancreas Transplantation: Phenotypic CharacteristicsDifferentiating Aggressive from Nonaggressive Transplant Centers
O. K. Serrano,¹ D. M. Vock,² T. B. Dunn,¹ R. Kandaswamy,¹ E. B. Finger.¹
¹Surgery, University of Minnesota, Minneapolis, MN; ²Biostatistics, University of Minnesota, Minneapolis, MN.
OBJECTIVE: Given the increasing shortage of deceased donor pancreas allografts and their declining acceptance rate, maximizing utilization requires a balance between donor selection and transplant…
2018 American Transplant Congress
Accepting a DCD Liver May Improve Patient Survival Compared to Waiting for a Non-DCD Liver
A. Wey,¹ N. Salkowski,¹ J. Lake,² W. Kim,³ B. Kasiske,¹ A. Israni,¹ J. Snyder.¹
¹Scientific Registry of Transplant Recipients, Minneapolis; ²Univ of Minnesota, Minneapolis; ³Stanford University, Palo Alto.
Only ~50% of liver candidates undergo deceased donor transplant; 17% die on the waiting list and 20% are removed from the list as too sick…
2018 American Transplant Congress
Estimation of Mortality on the Wait List
S. Asrani, L. Jennings, J. Trotter, G. Klintmalm.
Baylor University Medical Center, Dallas, TX.
Background: Since the introduction of MELD and MELDNa, the waitlist population has changed. Further, serum creatinine is a poor surrogate of renal dysfunction in patients…
2018 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
J. Assaker,¹ A. Srivastava,¹ J. Hurley,² B. Al Doujailan,¹ S. Eskandari,¹ C. Coticchia,² M. Mohamed,¹ S. Bentink,² V. Tadigotla,² L. Riella,¹ A. Chandraker,¹ J. Skog,² J. Azzi.¹
¹Transplantation Renal Center, BWH and BCH, Boston; ²Exosome Diagnostic Inc., Cambridge.
Kidney transplant rejection leads to short and long-term adverse clinical outcomes. Serum creatinine is a suboptimal late biomarker for rejection. Exosomes are nanometer-sized vesicles released…
2018 American Transplant Congress
Improving Prognostication amongst Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma: An International, 16-Center Study to Validate and Recalibrate HALTHCC
D. Firl,¹ K. Sasaki,¹ S. Kimura,² W. Dumronggittigule,³ A. Gorgen,⁴ J. Lerut,⁵ M. Rossi,⁶ U. Cillo,⁷ A. Viveiros,⁸ E. Tsochatzis,⁹ G. Otto,¹⁰ G. Ettorre,¹¹ G. Tisone,¹² M. Vivarelli,¹³ S. Agnes,¹⁴ J. Markmann,² T. Ikegami,¹⁵ T. Kaido,¹⁶ G. Sapisochin,⁴ V. Agopian,³ Q. Lai,^5,6 F. Aucejo.¹
¹CCF, Cleveland; ²MGH, Boston; ³UCLA, LA; ⁴UHN, Toronto, Canada; ⁵SLH, Louvain, Belgium; ⁶UH, Rome, Italy; ⁷UP, Padua, Italy; ⁸MUI, Innsbruck, Austria; ⁹UCL, London, United Kingdom; ¹⁰UM, Mainz, Germany; ¹¹SCH, Rome, Italy; ¹²TVU, Rome, Italy; ¹³AOU, Torrette Ancona, Italy; ¹⁴AGH, Rome, Italy; ¹⁵KU, Kyoto, Japan; ¹⁶KU, Kyushu, Japan.
Objective: Prognosticating outcomes in liver transplant (LT) for hepatocellular carcinoma (HCC) continues to challenge the field. Whereas adoption of the binary Milan Criteria (MC) generalized…
2018 American Transplant Congress
Elucidating Novel Signatures of Allograft Rejection through Cytometry by Time of Flight (CyTOF) in Kidney Transplant Recipients
S. Eskandari,¹ B. Al Dulaijan,¹ J. Assaker,¹ L. Riella,¹ A. Kurdi,² J. Azzi.¹
¹Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Mass cytometry by time-of-flight (CyTOF) permits the simultaneous assessment of over 40 functional and phenotypic parameters at the single-cell level. This novel tool holds tremendous…
2018 American Transplant Congress
The Utility of an Online Survival Calculator in Selecting Older Candidates for Kidney Transplantation
M. Shwetar, K. Abdel-Kader, B. Concepcion.
Vanderbilt University Medical Center, Nashville, TN.
Background: Older patients referred for kidney transplantation are medically complex. A posttransplant survival prediction model is publicly available online and may aid physicians in selecting…