ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preclinical trails"

  • 2018 American Transplant Congress

    Immunomodulation of Alloantibody Responses

    C. Schuetz, M. Climov, A. Paril, Z. Wang, A. Andrews Roy, N. Navarro Alvarez, A. Matar, D. Sachs, R. Duran-Struuck, C. Huang.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    We have shown that i.v. exposure to MHC-mismatched donor PBMC using a novel, mild conditioning protocol results in B-cell tolerance with transient T-cell unresponsiveness. Here…
  • 2017 American Transplant Congress

    Dual Targeting of Costimulation and Proteasome to Desensitize and Prolong Graft Survival of Sensitized Nonhuman Primates.

    J. Kwun,1 C. Burghuber,1 M. Manook,1 B. Ezekian,1 J. Park,1,2 K. Freishlag,1 J. Yoon,1 N. Iwakoshi,3 A. Farris,4 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Surgery, Samsung Medical Center, Seoul, Korea; 3Surgery, Emory Transplant Center, Atlanta, GA; 4Pathology, Emory University, Atlanta, GA

    [Background] Pre-formed donor-specific anti-HLA antibodies (DSA) from prior transplantation, transfusion, or pregnancy affects a significant portion (35%) of patients awaiting a kidney transplant. Highly sensitized…
  • 2017 American Transplant Congress

    Induction of Proliferative Responses in B Cell and Plasma Cell Populations Following Proteasome Inhibitor Desensitization Treatment in Rhesus Macacques and Humans.

    J. Driscoll,1 S. Knechtle,2 J. Kwun,2 S. Tremblay,1 N. Salomonis,3 S. Potter,3 B. Aronow,3 M. Manook,2 R. Alloway,1 H. Singh,3 E. Woodle.1

    1U of Cincinnati, Cincinnati; 2Duke, Durham; 3Cincinnati Childrens, Cincinnati

    Proteasome inhibitor (PI)-based desensitization (DS) in humans has demonstrated variable reduction in HLA antibody levels that is often associated with variable rebound following treatment cessation.The…
  • 2017 American Transplant Congress

    Combination αCD28+αCD40 Costimulation Blockade Attenuates Acute and Chronic Rejection in Non-Human Primates.

    N. O'Neill, T. Zhang, W. Sun, G. Braileanu, X. Cheng, I. Tatarov, W. Hassanein, A. Azimzadeh, R. Pierson.

    University of Maryland School of Medicine, Baltimore, MD

    Purpose: Monotherapy using αCD28 or αCD40 antibodies significantly prolongs graft survival but does not induce tolerance in non-human primates (NHP). Here, we evaluate the relative…
  • 2017 American Transplant Congress

    Does Blockade of ICOS/ICOS-L Pathway Act Synergistically with αCD40 Costimulation Pathway Blockade?

    N. O'Neill, T. Zhang, X. Cheng, W. Sun, G. Braileanu, I. Tatarov, W. Hassanein, A. Azimzadeh, R. Pierson.

    University of Maryland School of Medicine, Baltimore, MD

    Purpose: Inducible costimulator (ICOS) on T cells enhances basic T cell responses to foreign antigen, and increased ICOS expression is detected in association with pathogenic…
  • 2016 American Transplant Congress

    Radiosensitive Cell Population Prolongs Graft Survival of Vascularized Composite Allografts in Non-Human Primates.

    M. Uluer, J. Woodall, W. Hassanein, U. Drhu, B. Bojovic, A. Nam, S. Bartlett, R. Barth.

    University of Maryland School of Medicine, Baltimore, MD.

    Background: Vascularized composite allografts (VCA) containing vascularized bone marrow (VBM) prolong graft survival. To help elucidate this protective immunomodulatory effect, we irradiated donor facial VCA…
  • 2016 American Transplant Congress

    Ex Vivo Expansion and Functional Characterization of Human Alloantigen-Specific Regulatory T Cells.

    J. Mathew,1 S. McEwen,1 I. Konieczna,1 X. Huang,1 J. He,1 R. Kornbluth,2 J. Miller,1 L. Gallon,1 J. Leventhal.1

    1Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; 2Multimeric Biotherapeutics, Inc, La Jolla, CA.

    Purpose: Regulatory T cells (Tregs) have been associated with clinical transplant tolerance and they have been shown to prolong graft survival in animal models without…
  • 2015 American Transplant Congress

    CD28-Directed Therapy Prolongs Survival in a Non-Human Primate Kidney Transplant Model

    L. Higginbotham,1 D. Mathews,1 C. Breeden,1 W. Wakwe,1 C. Larsen,1 S. Nadler,2 A. Adams.1

    1Emory Transplant Center, Emory University School of Medicine, Atlanta; 2Bristol-Myers Squibb, Princeton.

    Introduction. Costimulation blockade using belatacept has the potential to improve long-term renal function and reduce cardiovascular risk by avoiding calcineurin inhibitors, yet higher rates and…
  • 2015 American Transplant Congress

    Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft

    S. Ville,1 N. Poirier,1,2 B. Vanhove,1,2 G. Blancho.1

    1INSERM, UMR1064, ITUN, Nantes, France; 2Effimune SAS, Nantes, France.

    B7 molecules on antigen-presenting cells interact with CD28 and CTLA4 on T lymphocytes to control TCR-mediated signals. Whereas it is highly efficient to block T…
  • 2015 American Transplant Congress

    Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival

    J. Kwun, C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, S. Knechtle.

    Surgery, Emory Transplant Center, Atlanta, GA.

    [Background] Preformed donor specific antibody (DSA) due to prior sensitization affects a significant population of transplant patients, portending a poorer prognosis in short- and long-term…
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