ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preclinical trails"

  • 2019 American Transplant Congress

    The Role of CD47/SIRPα and CD47/TSP-1 Pathways in Pig-to-Baboon Kidney Transplantation Using hCD47 Transgenic Kidneys

    K. Takeuchi1, Y. Ariyoshi1, T. Pomposelli1, L. Boyd1, D. Ekanayake-Alper1, S. Arn1, R. Hawley1, D. Ayares2, M. Lorber3, M. Sykes1, D. Sachs1, R. Johnson4, K. Yamada1

    1CCTI/Surgery, Columbia University Medical Center, New York, NY, 2Revivicor Inc., Blacksburg, VA, 3Lung BioTechnology PBC, Silver Spring, MD, 4Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO

    *Purpose: We have recently reported that both CD80 upregulation and the degradation of SMPDL-3b on glomerular podocytes are involved in the development of post kidney…
  • 2019 American Transplant Congress

    Newly-Revealed Antibody Targets Lead to the Early Loss of Triple Knockout Pig Kidneys in a Pig to Baboon Model

    Y. Ariyoshi1, K. Takeuchi1, T. Pomposelli1, D. K. Ekanayake-Alper1, C. Schuetz1, H. Sahara1, L. Boyd1, E. Estime1, S. Arn1, D. Ayares2, M. Lorber3, M. Sykes1, D. Sachs1, K. Yamada1

    1CCTI/Surgery, Columbia University Medical Center, New York, NY, 2Revivicor Inc., Blacksburg, VA, 3Lung BioTechnology PBC, Silver Spring, MD

    *Purpose: We have achieved >6 months survival of a life-supporting kidney with a vascularized thymus (VT) in a pig-to-baboon model. While improved survival has been…
  • 2019 American Transplant Congress

    A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 is Safe and Immunogenic in Healthy Volunteers and Entering a Phase 2 Trial in Kidney Transplant Recipients

    C. N. Kotton1, M. Schwendinger2, G. Thiry3, B. De Vos4, F. De Boever5, G. Leroux-Roels6, A. Lilja7

    1Infectious Diseases Division, Boston, MA, 2Hookipa Biotech AG, Vienna, Austria, 3Hookipa Biotech GmbH, VIenna, Austria, 4Bejamad sprl/bvba, Beersel, Belgium, 5Centrum voor vaccinologie (CEVAC), Gdent, Belgium, 6Centrum voor vaccinologie (CEVAC), Gent, Belgium, 7Hookipa Biotech GmbH, Vienna, Austria

    *Purpose: Cytomegalovirus (CMV) is a significant pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and resistance. A safe and…
  • 2019 American Transplant Congress

    Complement Blockade in Kidney Recipients Prevents Delayed Graft Function and Antibody-Mediated Rejection in Non-Human Primates

    M. Eerhart1, J. Reyes1, C. Blanton1, J. Danobeitia1, P. Chlebeck1, L. Zitur1, J. Coonen1, S. Capuano1, A. D’Alessandro1, J. Torrealba2, W. Zhong1, Y. Yankol1, L. Fernandez1

    1University of Wisconsin, Madison, WI, 2UT Southwestern, Dallas, TX

    *Purpose: Ischemia-reperfusion injury (IRI) leading to inflammation, complement activation, cytokine release and acute kidney injury has been implicated in the mechanism for delayed graft function…
  • 2019 American Transplant Congress

    Achieving Robust Targeting of Antibody-Conjugated Nanoparticles Delivered during Ex Vivo Machine Perfusion of Human Kidneys

    J. R. DiRito1, S. Hosgood1, M. L. Nicholson1, G. Tietjen2

    1Surgery, University of Cambridge, Cambridge, United Kingdom, 2Surgery, Yale School of Medicine, New Haven, CT

    *Purpose: In this study we seek to improve targeted nanoparticle (NP) delivery during ex-vivo normothermic machine perfusion through fibrinolysis for more homogenous treatment of human…
  • 2019 American Transplant Congress

    Oral Preconditioning of Donors after Brain Death with Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation

    S. Abbasi Dezfouli1, M. Golriz1, O. Ghamarnejad1, E. Khajeh1, S. Mohammadi1, M. Nikdad1, A. Majlesara1, M. Sabagh1, P. Fathi1, S. Shafiei1, M. Kentar2, A. Younsi2, C. Eckert3, T. Poth3, A. Mehrabi1, A. Nickkholgh1

    1Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany, 2Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany, 3Department of Pathology, University of Heidelberg, Heidelberg, Germany

    *Purpose: The systemic inflammatory cascade triggered in donors after brain death (DBD) enhances the ischemia-reperfusion injury (IRI) after organ transplantation. Data regarding donor preconditioning with…
  • 2019 American Transplant Congress

    The Number of Donor-Specific IL-21 Producing Cells before and after Transplantation Predicts Kidney Graft Rejection

    N. M. van Besouw1, L. Yan1, R. de Kuiper1, M. Klepper1, D. Reijerkerk1, M. Dieterich1, D. L. Roelen2, F. H. Claas2, M. C. Clahsen-van Groningen3, D. A. Hesselink1, C. C. Baan1

    1Internal Medicine - Nephrology & Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, 2Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands, 3Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

    *Purpose: Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We…
  • 2018 American Transplant Congress

    Successful Patency in Blood Conduits for an Artificial Kidney Membrane with Biocompatible Coatings

    R. Forbes,1 E. Marsh,1 S. Karp,1 A. Buck,1 D. Colvin,1 P. Williams,1 B. Chaudhuri,2 S. Roy,2 W. Fissell.1

    1VUMC, Nashville; 2UCSF, San Francisco.

    BACKGROUND: An implantable artificial kidney may address the growing organ shortage and improve outcomes and quality of life for those with end stage renal disease.…
  • 2018 American Transplant Congress

    The Preclinical Application of the Tactile Discrimination Task in Rat Models

    S-.H. Wu,1,2 C-.J. Wen,1,2 J-.J. Huang,1,2,3 Y-.C. Pei,1,2,3 C-.H. Lin,1,2,4,5 H. Cheng,1 Z-.L. Peng,1,4,5 H-.I. Yang,6 F-.C. Wei.1,2,5

    1Center for Vascularized Composite Allotransplantation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Physical Medicine & Rehabilitation, Taoyuan Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Division of Trauma and Emergency Plastic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Division of Plastic Reconstructive Microsurgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 6Department of Electronic Engineering, National Taipei University of Technology, Taipei, Taiwan.

    Nerve reinnervation is an important issue in the field of vascularized composite allotransplantation (VCA). However, nowadays the effective treatment for enhancing the reinnervation after the…
  • 2018 American Transplant Congress

    Tomotherapy and Donor Hematopoietic Cells for Tolerance to Kidney Transplants in Rhesus Macaques

    D. Kaufman,1 L. Haynes,1 P. Hematti,1 W. Burlingham,1 L. Forest,2 J. Post,1 R. Redfield,1 L. Fernandez,1 A. D'Alessandro,1 J. Haynes,1 K. Jensen,3 S. Strober.3

    1Surgery, University of Wisconsin School of Medicine, Madison, WI; 2Surgical Sciences, University of Wisconsin School of Vet Med, Madison, WI; 3Medicine, Stanford University Medical School, Palo Alto, CA.

    The goal of this project was to develop a tolerance induction protocol for MHC 1-haplotype mismatched kidney transplants (txs) in a rhesus macaque model. The…
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