ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Preclinical trails"

  • 2022 American Transplant Congress

    Life Supporting Orthotopic Cardiac Xenotransplantation Using Multiple Human Gene Expressing Pigs in Non Human Primates

    A. K. Singh1, C. Goerlich1, T. Zhang1, I. Tatarov1, P. Odonkor1, E. Strauss1, B. Williams1, B. Lewis1, A. Hershfeld1, F. Sentz1, D. Ayares2, D. Kaczorowski1, B. Griffith1, M. Mohiuddin1

    1Department of Surgery, University of Maryland, Baltimore, MD, 2Revivicor Inc, Blacksburg, WV

    *Purpose: Cardiac xenotransplantation (CXTx) is proposed as an alternate treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically engineered (GE) pig…
  • 2022 American Transplant Congress

    Long-Term Rejection Free Renal Allograft Survival with Fc-Modified Anti-cd154 Antibody Monotherapy in Nonhuman Primates

    G. Lassiter, T. Hirose, A. D’Attilio, T. Kawai

    MGH Center for Transplantation Sciences, Boston, MA

    *Purpose: Belatacept is currently the only FDA approved costimulatory blockade (CB) used as an alternative to calcineurin inhibitors in kidney transplantation. However, it has been…
  • 2022 American Transplant Congress

    Leveraging Car T Cells To Achieve Desensitization And Enable Transplantation

    V. BHOJ

    UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

    *Purpose: Pre-existing allo-antibodies (allo-Abs), that preclude transplant due to the risk of hyperacute rejection, lead to prolonged wait times and high mortality rates. Current desensitization…
  • 2022 American Transplant Congress

    Tolerance of Allogeneic Kidneys with Durable (>200 Days) Multilineage Chimerism and Bone Marrow Engraftment in Cynomolgus Macaques

    Y. Tomori1, Y. Hisadome1, D. Eisenson1, K. Takeuchi1, K. Okubo1, C. Huang2, D. Sachs1, M. Sykes1, K. Yamada1

    1CCTI/Surgery and Medicine, Columbia University, New York, NY, 2University of Colorado Denver, Aurora, CO

    *Purpose: We have previously reported that a regimen including anti-CD3 immunotoxin, 45 days of cyclosporine, and pre-transplant total body irradiation (TBI) promoted tolerance of kidney…
  • 2021 American Transplant Congress

    Combined CD11b/CD40 Blockade is Superior to CD40 Blockade Alone in Prolonging Survival in Pig-to-Nonhuman Primate Renal Xenotransplantation

    D. A. Faber1, B. Lovasik1, A. Matar1, C. Breeden1, S. Kim1, A. Adams2

    1Surgery, Emory University School of Medicine, Atlanta, GA, 2Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Blockade of the CD40/CD154 pathway is highly effective in preventing rejection in pig-to-nonhuman primate (NHP) xenotransplantation models. Clinical translation of anti-CD154 mAbs, however, has…
  • 2021 American Transplant Congress

    Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model

    M. Manook1, W. Flores2, R. Schmitz1, Z. Fitch1, J. Yoon1, Y. Bae1, B. I. Shaw1, M. Harnois3, S. Permar3, A. Kirk1, D. Magnani2, J. Kwun1, S. Knechtle1

    1Duke Transplant Center, Duke University Medical Center, Durham, NC, 2Massbiologics, University of Massachusetts Medical School, Boston, MA, 3Human Vaccine Institute, Duke University Medical Center, Durham, NC

    *Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…
  • 2021 American Transplant Congress

    Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches

    M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle

    Duke Transplant Center, Duke University Medical Center, Durham, NC

    *Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
  • 2021 American Transplant Congress

    Complement Blockade Improves Renal Xenograft Survival in Primates in the Absence of Transgenic Complement Regulatory Proteins

    D. A. Faber1, B. Lovasik1, A. Matar1, C. Breeden1, A. B. Farris2, M. Tector3, A. Tector3, A. Adams4

    1Surgery, Emory University School of Medicine, Atlanta, GA, 2Pathology, Emory University School of Medicine, Atlanta, GA, 3Surgery, University of Miami, Miami, FL, 4Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Complement activation is a major contributor to xenograft rejection. To minimize xenograft injury, complement suppression via insertion of human complement-regulatory transgenes into the donor…
  • 2021 American Transplant Congress

    Sampling Renal Biopsies in Pre-Clinical Research for Comprehensive Assessment

    C. M. Edwards1, C. Albert2, D. Stern1, J. Langford1, W. Day2, J. R. DiRito1, W. M. Saltzman2, M. Kashgarian3, J. S. Pober4, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale School of Medicine, New Haven, CT, 3Pathology, Yale School of Medicine, New Haven, CT, 4Immunobiology, Yale School of Medicine, New Haven, CT

    *Purpose: Previous literature has demonstrated that single biopsies are not representative of a whole kidney in clinical assessments. In this study we aimed to design…
  • 2021 American Transplant Congress

    Clazakizumab (clz, Anti-il-6 Antibody) Treatment Affects Il-6/il-6r Signaling by Increasing Soluble Gp130 (sgp130) in Hla-sensitized Kidney Transplant Patients (hs Ktx Pts) Treated for Chronic Antibody-mediated Rejection (cabmr)

    B. Shin, S. Ge, A. Jimenez, N. Ammerman, A. Vo, R. Zhang, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Cerritos, CA

    *Purpose: IL-6 is a pro-inflammatory cytokine responsible for chronic vascular inflammation and a promising target for cABMR modulation. IL-6/sIL-6R complex initiates more pathogenic trans-signaling pathways…
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