Articles tagged "Polyma virus"

2018 American Transplant Congress
HLA Mismatching and cPRA Do Not Affect BK Viremia and Nephropathy Risk in Kidney Transplantation: A Retrospective Analysis
B. Suleiman, S. Saleh, W. Hassan, K. Wang, A. Maibam, A. Karim, A. Hines, X. Mei, A. El-Husseini, M. Yaseen, V. Cornea, A. Castellanos, R. Gedaly, T. Waid.
Nephrology, University of Kentucky, Lexington, KY.
Introduction:Nephropathy from BK virus is a significant complication of kidney transplantation and occurs following a period of viremia. Patients who are HLA mismatched and more…
2018 American Transplant Congress
The Risk Factors of Acute Rejection in Patients with BK Nephropathy after the Reduction of Immunosuppression
C. Baek,¹ H. Kim,¹ W. Yang,¹ D. Han,² S-.K. Park.¹
¹Department of Internal Medicine, Division of Nephrology, Asan Medical Center, Seoul, Republic of Korea; ²Department of Surgery, Asan Medical Center, Seoul, Republic of Korea.
Background: BK nephropathy (BKN) affects graft function and increases the risk of graft failure. The reduction of immunosuppression is the main treatment for BKN. However,…
2018 American Transplant Congress
Multiplexed Immunofluorescence to Investigate the Immune Response to BK Virus in Pediatric Kidney Transplant Recipients
C. Fajardo,¹ P. Grimm,¹ N. Kambham,² G. Nolan,³ N. Samusik,³ J. Maltzman.³
¹Pediatrics, Stanford, Stanford, CA; ²Pathology, Stanford, Stanford, CA; ³Immunology, Stanford, Stanford, CA.
Background: BK virus-associated nephropathy (BKVN) is a significant complication in renal transplantation that leads to allograft dysfunction or failure. BKV is thought to reactivate as…
2018 American Transplant Congress
Medullary Tissue Sampling in Renal Allograft Biopsy is More Sensitive for Pathologic Diagnosis of PVN
D. Abdelwahab,¹ H. Khamash,¹ S. Kriegshauser,³ R. Heilman,¹ M. Smith.²
¹Nephrology and Transplant, Mayo Clinic, Phoenix; ²Pathology and Laboratory Medicine, Mayo Clinic, Phoenix; ³Radiology, Mayo Clinic, Phoenix.
Background Post-transplant polyoma virus nephropathy (PVN) prevalence is 1-10%. Definitive PVN diagnosis requires polyoma virus presence in infected cells, done with immunohistochemical staining for SV40…
2018 American Transplant Congress
Role of BK Virus-Specific T Cell Immune Monitoring for BK Virus-Associated Nephropathy in Kidney Transplant Recipients
J. Bruminhent,¹ S. Srisala,² C. Klinmalai,³ S. Pinsai,¹ S. Watcharananan,¹ S. Kantachuvessiri,⁵ S. Hongeng,⁴ N. Apiwattanakul.³
¹Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ²Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ³Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁴Division of Hematology and Oncology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ⁵Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: Reduced immunosuppression in a key therapy for BK virus (BKV)-associated nephropathy (BKVAN) in kidney transplant (KT) recipients. A study of immune monitoring against BKV…
2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
B. Adam,¹ S. Wagner,¹ J. Bräsen,² V. Bröcker,² V. D'Agati,³ C. Drachenberg,⁴ E. Farkash,⁵ A. Farris,⁶ L. Geldenhuys,⁷ A. Magil,⁸ V. Nickeleit,⁹ P. Randhawa,¹⁰ H. Regele,¹¹ M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Hannover Medical School, Hannover, Germany; ³Columbia University, New York; ⁴University of Maryland, College Park; ⁵University of Michigan, Ann Arbor; ⁶Emory University, Atlanta; ⁷Dalhousie University, Halifax, Canada; ⁸University of British Columbia, Vancouver, Canada; ⁹University of North Carolina, Chapel Hill; ¹⁰University of Pittsburgh, Pittsburgh; ¹¹Medical University of Vienna, Vienna, Austria.
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…
2018 American Transplant Congress
Association between Donor/Recipient BK Viral Serostatus and Risk of BK Viraemia Post-Transplantation
S. Chong,¹ C. Atkinson,² N. Banga,¹ M. Harber,¹ M. Reeves,² C. Magee.¹
¹Royal Free London NHS Foundation Trust, London, United Kingdom; ²Department of Virology, University College London, London, United Kingdom.
IntroductionThe development of BK viraemia, and subsequently, BK nephropathy is a potentially devastating event associated with kidney transplant loss. In contrast to other clinically important…
2018 American Transplant Congress
Diagnostic Value and Confounding Factors of Urinary Biomarkers in the Non-Invasive Screening of Renal Allograft Inflammation
A. Vermorel,¹ A. Devresse,¹ C. Tinel,^1,2 V. Sauvaget,² L. Morin,² L. Amrouche,^1,2 M. Rabant,^2,3 D. Anglicheau.^1,2
¹Renal Transplantation Unit, Necker-Enfants Malades Hospital, Paris, France; ²INSERM U1173, Institut Necker Enfants Malades, Paris, France; ³Pathology, Necker-Enfants Malades Hospital, Paris, France.
IntroductionThe value of urinary biomarkers has already been demonstrated in diagnosing acute rejection of the renal allograft, but confounding factors, which may interfere with their…
2018 American Transplant Congress
Prevalence, Risk Factors and Impact of BK Viremia on Kidney Transplantation: Single Center Experience
W. Hassan, A. El-Husseini, B. Suleiman, K. Wang, M. Yaseen, A. Maibam, A. Karim, A. Hines, A. Castellanos, V. Cornea, X. Mei, R. Gedaly, T. Waid.
Nephrology, University of Kentucky, Lexington, KY.
Introduction: BK viremia (BKV) is an emerging problem in renal transplantation. The risk factors and the impact of BKV on renal allograft and patient survival…
2018 American Transplant Congress
Viral-Specific Cytotoxic T-Cell (Viral-Tc) Responses in Highly-HLA-Sensitized Patients (HS) Maintained on Tacrolimus and Everolimus Post-HLAi Kidney Transplant
S. Ge,¹ M. Chu,¹ A. Karasyov,¹ D. Lovato,¹ J. Kahwaji,² A. Vo,¹ J. Choi,¹ S. Louie,¹ S. Jordan,¹ M. Toyoda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Kidney Transplantation, Kaiser Permanente Medical Center, Los Angeles, CA.
Introduction: Viral infections represent significant infectious complications post- kidney transplant which may be increased with desensitization. CMV, EBV and BKV infections are the most prevalent.…