Articles tagged "Polyma virus"

2018 American Transplant Congress
Viral-Specific Cytotoxic T-Cell (Viral-Tc) Responses in Highly-HLA-Sensitized Patients (HS) Maintained on Tacrolimus and Everolimus Post-HLAi Kidney Transplant
S. Ge,¹ M. Chu,¹ A. Karasyov,¹ D. Lovato,¹ J. Kahwaji,² A. Vo,¹ J. Choi,¹ S. Louie,¹ S. Jordan,¹ M. Toyoda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Kidney Transplantation, Kaiser Permanente Medical Center, Los Angeles, CA.
Introduction: Viral infections represent significant infectious complications post- kidney transplant which may be increased with desensitization. CMV, EBV and BKV infections are the most prevalent.…
2018 American Transplant Congress
JC Virus-Associated Nephropathy in Renal Transplant Recipient
G. Huang,¹ M. Wang,² X. Chen,¹ S-.C. Yang,³ L. Chen.¹
¹Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Sun Yat-sen University, Guangzhou, China; ³Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: JC virus (JCV) inflection is more common than BK virus (BKV) in general population. But in kidney transplants, polyomavirus nephropathy (PVAN) is primarily caused…
2018 American Transplant Congress
Comparison of Recipients with Early and Late Presenting Polyomavirus Nephropathy (PVN) with Regard to Histological Findings and Graft Survival: What is the Influence of CD4/CD8 Ratio on the Presenting Time of PVN
B. Ozdemir,¹ S. Ayva,¹ A. Terzi,¹ A. Ok Atilgan,¹ E. Akcay,¹ E. Ayvazoglu Soy,² F. Ozdemir,³ M. Haberal.²
¹Pathology, Baskent University, Ankara, Turkey; ²Transplantation, Baskent University, Ankara, Turkey; ³Nephrology, Baskent University, Ankara, Turkey.
Introduction: PVN is a common complication occurring around 12 mo after renal transplant (RT). We aimed to explore the differences between early and late-onset PVN…
2018 American Transplant Congress
Long-Term Prognosis of BK Virus Associated Nephropathy in Kidney Transplant Recipients
W. Park,^1,3 S. Yeo,¹ S. Kang,^1,3 H. Park,¹ K. Jin,^1,3 S. Park,^1,3 M. Choe,^2,3 S. Han.^1,3
¹Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea; ²Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea; ³Keimyung University Kidney Institute, Daegu, Republic of Korea.
Background: BK virus-associated nephropathy (BKVAN) is an important risk factor that results in an allograft loss in kidney transplant recipients (KTRs). The short-term prognosis of…
2018 American Transplant Congress
Origin and Pattern of Human Polyomaviruses Replication after Kidney Transplantation: A Prospective Study
E. Favi,¹ S. Delbue,² C. Colico,¹ P. Ferrante,² S. Villani,² I. Perna,² N. Mondoni,² A. Giussani,¹ L. Clementoni,¹ P. Messa,³ M. Ferraresso.¹
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; ³Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy.
Background. Human Polyomaviruses (HPyVs) are able to establish latent infection in the kidney of the host. Immunosuppression is recognized risk factor for HPyVs reactivation. Besides…
2018 American Transplant Congress
Characteristics of Polyomavirus Nephropathy in Renal Transplant Recipient in China: 10 Year Experience
G. Huang, X. Chen, L. Chen.
Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Till now regular BKV screening after kidney transplantation is not performed in many transplant centers in China. As several noninvasive methods were available in…
2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
D. Dadhania,¹ P. Burnham,² J. Lee,¹ C. Snopkowski,¹ C. Li,¹ S. Albakry,¹ H. Yang,¹ T. Muthukumar,¹ I. De Vlaminck,² M. Suthanthiran.¹
¹Transplantation Medicine-Nephrology, Weill Cornell Medicine, NY, NY; ²Biomedical Engineering, Cornell University, Ithaca, NY.
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…
2018 American Transplant Congress
Treatment of BK Viremia: Single-Center Experience
A. Karim, A. Hines, K. Wang, S. Saleh, B. Suleiman, W. Hassan, A. Maibam, M. Yaseen, A. Castellanos, V. Cornea, X. Mei, R. Gedaly, T. Waid, A. El-Husseini.
Nephrology, University of Kentucky, Lexington, KY.
INTRODUCTION:BK viremia (BKV) and BK virus nephropathy (BKVN) is recognized as an emerging problem in renal transplant recipients. Only reduction of immunosuppressants had shown efficacy…
2018 American Transplant Congress
Clinical Significance of BK Virus-Specific ELISPOT Assay in Kidney Transplant Recipients
J. Chang,^1,2 H. Bae,³ K. Park,³ H. Lee,³ B. Choi,^1,2 C. Park,^1,2 C. Yang,^1,2 Y. Kim,^1,2 E-.J. Oh,^1,4 B. Chung.^1,2
¹Transplant Research Center, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ³Department of Biomedical Science, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ⁴Department of Laboratory Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
This study aimed to investigate whether BK virus (BKV)-specific T-cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BKV…
2018 American Transplant Congress
Early Association of Low Doses of Tacrolimus and a mTOR Inhibitor in BK Polyomavirus Infection in Kidney Transplant Recipients
V. Lopez,¹ T. Vazquez,¹ C. Jironda,¹ M. Cabello,¹ E. Sola,¹ M. Leon,² E. Marques,¹ D. Hernandez.¹
¹Nephrology, Hospital Regional Malaga, Malaga, Spain; ²Pathology, Hospital Regional Malaga, Malaga, Spain.
Introduction: BK polyomavirus (BKV) replication can be detected in up to 60% of kidney transplant recipients, with an incidence of nephropathy of 5-10%, leading to…