2018 American Transplant Congress
Y-Adapter Mediated Next Gen Sequencing of BKPyV from Archived FFPE Tissue
1Pathology, Michigan Medicine, Ann Arbor; 2Michigan Medicine, Ann Arbor.
Background: In a subset of renal transplant recipients with urothelial carcinoma, tumor cells show universal expression of BK Polyomavirus (BKPyV) proteins, a hallmark of oncoviruses.…2018 American Transplant Congress
Increased Gene Expression of TGF-b in Renal Transplant Patients with Polyomavirus BK Viremia
Objective: We aimed to investigate the roles of cytokines during polyomavirus BK (BKV) reactivation in renal transplant patients.Materials and Methods: Fortyeight renal allograft recipients were…2018 American Transplant Congress
Kidney Transplant Patients with Polycystic Kidney Disease Have a Lower Risk of Post-Transplant BK Infection Compared to Other Causes of ESRD
University of Wisconsin Madison, Madison, WI.
Purpose: Polyomavirus-associated nephropathy is associated with high rates of allograft loss among kidney transplant patients. Whether the cause of native end-stage renal disease (ESRD) impacts…2018 American Transplant Congress
Induction Therapy with Low-Dose Rituximab Could Be a Risk Factor of BKV Associated Nephropathy in Kidney Transplant Recipients
1Nephrology, Hirosaki University, Hirosaki, Japan; 2Urology, Hirosaki University, Hirosaki, Japan.
Background.In kidney transplant recipients, BK polyoma virus (BKV) infection is common and serious complication that could lead to graft loss. Previous studies reported that 30-40%…2018 American Transplant Congress
Incidence of BK Viraemia and BK Virus Associated Nephropathy with Standard vs. Augmented Immunosuppression
Renal Transplant, University Hospitals of Coventry and Warwickshire, Coventry, United Kingdom.
Introduction:It has been long established that over-immunosuppressed state leads to BK virus reactivation. BK viraemia (BKV) can progress to BK virus associated nephropathy (BKVAN) which…2018 American Transplant Congress
Ciprofloxacin for BK Viremia Prophylaxis in Kidney Transplant Recipients: Results of a Prospective, Randomized Controlled Trial
Houston Methodist Hospital, Houston, TX.
Fluoroquinolone (FQ) antibiotics have in vitro activity against BK virus, with several reports indicating they may reduce the risk of BK infection in kidney transplant…2018 American Transplant Congress
Higher Concordance in the Incidence of DGF and Post-Transplant BKV Infection among Recipients Receiving Mate Kidneys from the Same Deceased Donor: A Paired Deceased Donor Kidney Transplant Analysis
Background: This study was undertaken to explore the degree to which donor variables impact rates of DGF, post-transplant CMV and BKV infections using a paired…2018 American Transplant Congress
Mycophenolic Acid Reduces BK Polyomavirus Replication in an In Vitro Model of Renal Tubular Epithelial Cells Infection
Background. BK virus (BKV) nephropathy is an important cause of allograft failure after kidney transplant. Immunosuppression is a recognized risk factor for BKV replication but…2018 American Transplant Congress
Aggressive Immunosuppression Minimization Shortens BK Viremia, Does Not Improve Outcome, but Increases the Risk of De Novo Donor Specific Antibodies in Kidney Recipients
Background: Immunosuppression (IS) minimization is the gold-standard treatment of BK virus (BKV) viremia in kidney transplant recipients (KTRs). However, the optimal approach to IS reduction…2018 American Transplant Congress
Prospective Study of Switching from Tacrolimus to Low-Dose Cyclosporine A Preserving Allograft Function in BK Virus-Associated Nephropathy
Background: Tacrolimus(Tac) -mycophenolic acid compared to cyclosporine is an independent risk factor for BK virus-associated nephropathy (BKVAN). Cyclosporine A (CsA) can inhibit BKV replication in…
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