Articles tagged "Polyma virus"

2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
D. Dadhania,¹ P. Burnham,² J. Lee,¹ C. Snopkowski,¹ C. Li,¹ S. Albakry,¹ H. Yang,¹ T. Muthukumar,¹ I. De Vlaminck,² M. Suthanthiran.¹
¹Transplantation Medicine-Nephrology, Weill Cornell Medicine, NY, NY; ²Biomedical Engineering, Cornell University, Ithaca, NY.
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…
2018 American Transplant Congress
Treatment of BK Viremia: Single-Center Experience
A. Karim, A. Hines, K. Wang, S. Saleh, B. Suleiman, W. Hassan, A. Maibam, M. Yaseen, A. Castellanos, V. Cornea, X. Mei, R. Gedaly, T. Waid, A. El-Husseini.
Nephrology, University of Kentucky, Lexington, KY.
INTRODUCTION:BK viremia (BKV) and BK virus nephropathy (BKVN) is recognized as an emerging problem in renal transplant recipients. Only reduction of immunosuppressants had shown efficacy…
2018 American Transplant Congress
Clinical Significance of BK Virus-Specific ELISPOT Assay in Kidney Transplant Recipients
J. Chang,^1,2 H. Bae,³ K. Park,³ H. Lee,³ B. Choi,^1,2 C. Park,^1,2 C. Yang,^1,2 Y. Kim,^1,2 E-.J. Oh,^1,4 B. Chung.^1,2
¹Transplant Research Center, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ³Department of Biomedical Science, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ⁴Department of Laboratory Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
This study aimed to investigate whether BK virus (BKV)-specific T-cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BKV…
2018 American Transplant Congress
Early Association of Low Doses of Tacrolimus and a mTOR Inhibitor in BK Polyomavirus Infection in Kidney Transplant Recipients
V. Lopez,¹ T. Vazquez,¹ C. Jironda,¹ M. Cabello,¹ E. Sola,¹ M. Leon,² E. Marques,¹ D. Hernandez.¹
¹Nephrology, Hospital Regional Malaga, Malaga, Spain; ²Pathology, Hospital Regional Malaga, Malaga, Spain.
Introduction: BK polyomavirus (BKV) replication can be detected in up to 60% of kidney transplant recipients, with an incidence of nephropathy of 5-10%, leading to…
2018 American Transplant Congress
Rejection and Graft Loss in Patients with BK Viremia after Simultaneous Pancreas and Kidney Transplant
D. Keys, S. Riad, V. Vakil, S. Jackson, D. Berglund, A. Matas, R. Kandaswamy.
University of Minnesota, Minneapolis, MN.
Background: BK virus is a recognized cause of kidney allograft dysfunction. The treatment of BK is immunosuppression reduction. This reduction in patients with a simultaneous…
2018 American Transplant Congress
Incidence of Rejection and Antibody Formation after Immunosuppression Reduction in Patients with Biopsy Proven Polyomavirus Nephropathy
M. Kleman, R. Detwiler, H. Singh, V. Nickeleit.
University of North Carolina, Chapel Hill, NC.
The purpose of this study is to determine the incidence of rejection and donor specific antibody (DSA) formation after immunosuppression reduction in patients with biopsy…
2018 American Transplant Congress
CMV and BKV Infections after Kidney Transplantation: Combined Tacrolimus/everolimus Strategy Using Antithymocyte Globulin Induction
T. Jouve,^1,4 R. Germi,^2,4 B. Janbon,¹ G. Fiard,^3,4 P. Malvezzi,¹ L. Rostaing.^1,4
¹Nephrology, Dialysis, Apheresis, Transplantation Unit, Grenoble University Hospital, Grenoble, France; ²Virology Unit, Grenoble University Hospital, Grenoble, France; ³Urology Unit, Grenoble University Hospital, Grenoble, France; ⁴Medical Sciences, Grenoble University, Grenoble, France.
Cytomegalovirus (CMV) and BK Virus (BKV) infections are frequent complications after kidney transplantation. A combined regimen of calcineurin inhibitor (CNI) and mTOR inhibitors (mTORi) reduces…
2018 American Transplant Congress
Impact of Age and Race on BK Viremia among Kidney Transplant Recipients
S. Mehta,^1,3 N. Ali,^1,3 B. Lonze,^2,3 A. Stachel.³
¹Medicine, New York University School of Medicine, New York, NY; ²Surgery, New York University School of Medicine, New York, NY; ³NYU Langone Health, New York, NY.
Background: Older age has been described as a potential risk factor for BK virus infection after kidney transplantation. The purpose of this study is to…
2018 American Transplant Congress
Y-Adapter Mediated Next Gen Sequencing of BKPyV from Archived FFPE Tissue
E. Harake,¹ W. Wu,² J. Opp,² E. Farkash.¹
¹Pathology, Michigan Medicine, Ann Arbor; ²Michigan Medicine, Ann Arbor.
Background: In a subset of renal transplant recipients with urothelial carcinoma, tumor cells show universal expression of BK Polyomavirus (BKPyV) proteins, a hallmark of oncoviruses.…
2018 American Transplant Congress
Increased Gene Expression of TGF-b in Renal Transplant Patients with Polyomavirus BK Viremia
W. Yin.
SURGERY, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia I, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
Objective: We aimed to investigate the roles of cytokines during polyomavirus BK (BKV) reactivation in renal transplant patients.Materials and Methods: Fortyeight renal allograft recipients were…