Articles tagged "Polyma virus"

2019 American Transplant Congress
BK Virus Infection among Kidney Transplant Recipients with High Immunological Risk and Strong Immunosupression
G. Ledesma, M. O. Lopez, G. Carreño, M. J. Santana, M. A. Vaca, E. Gonzalez, C. Jimenez
Nephrology, Hospital Universitario La Paz, Madrid, Spain
*Purpose: BK virus infection represents one of the main viral infections within the first year after kidney transplantation, closely linked to the degree of immunosupresion.…
2019 American Transplant Congress
The Utility of Donor and Recipient BK Virus Antibody Testing Prior to Renal Transplantation in Risk Assessment for Developing BK Viremia
N. Donmez, S. I. Al-Akash
Driscoll Children's Hospital, Corpus Christi, TX
*Purpose: The correlation between donor (DON) and recipient (REC) BKV antibody (AB) titers and BK viremia in renal transplant (RTx) has not been well-studied in…
2019 American Transplant Congress
Characteristics of Patients with Early vs Late BK Viremia after Kidney Transplantation
S. Rehman¹, J. Pryor², A. Olyaei³, M. Stack¹, D. Norman¹, J. Lockridge¹
¹Medicine/Nephrology, Oregon Health and Science University, Portland, OR, ²Oregon Health and Science University, Portland, OR, ³Pharmacy, Oregon Health and Science University, Portland, OR
*Purpose: To describe the characteristics of patients presenting with late BK viremia (>1 year after transplant) and compare to early BK viremia*Methods: This study was…
2019 American Transplant Congress
Immunosuppression Reduction after Diagnosis of Sustained BK Viremia and the Risk of Allograft Rejection, Allograft Loss and Mortality
F. A. Al Dhufairi¹, M. Shokoohi², A. M. Jevnikar¹, A. A. House¹, D. Kumar³, S. M. Hosseini-Moghaddam¹
¹Department of Medicine, Western University, London Health Sciences Centre, London, ON, Canada, ²Epidemiology and Biostatistics, Western University, London, ON, Canada, ³Department of Medicine, University Of Toronto, University Health Network, Toronto, ON, Canada
*Purpose: BK viremia increases the risk of allograft loss after renal transplantation. Current guidelines recommend immunosuppression reduction (IsR) after the diagnosis of BK viremia. The…
2019 American Transplant Congress
BK Virus Infection Disparity between Black and Other Races; Do Not Blame the Mycophenolic Acid
N. Raj¹, R. Spong¹, S. Jackson², V. Vakil¹, D. Keys¹, E. Finger³, S. Riad¹
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Disparities in kidney transplant outcomes between black recipients and others continue to exist. We sought to examine the impact of race and the differential…
2019 American Transplant Congress
Predictive Factors for BKV Nephropathy in Renal Transplant Recipients with BK Viruria
I. Alshaer, M. Bottomley, S. Mehta, J. Galante, I. Roberts, E. Sharples
Renal, Oxford University Hospitals, Oxford, United Kingdom
*Purpose: Polyoma infection due to BK virus remains an important cause of allograft failure following renal transplantation.Intensive monitoring of urine and serum for BK virus…
2019 American Transplant Congress
Genome-Wide Profiling of BK Polyomavirus Integration in Urothelial Carcinoma of Kidney Transplant Recipients Reveals a Potential Microhomology or Nonhomologous End Joining Mediated Integration Mechanism
Y. Jin¹, Y. Zhou¹, W. Deng¹, R. Lee², Y. Liu¹, M. Blute³, R. Liu¹, N. Elias⁴, F. Fu¹, B. Guan¹, J. Geng¹, J. Ma⁵, J. Zhou⁵, N. Liu⁵, C. Wu⁶, Y. Miao¹
¹Nanfang Hospital, Southern Medical University, Guangdzhou, China, ²Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Departments of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Mygenostics Co., Beijing, China, ⁶Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: Chronic BK polyomavirus (BKV) infection is recognized as a potential oncogenic factor of urothelial carcinoma (UC) in renal transplant recipients. Besides, a positive correlation…
2019 American Transplant Congress
Incidence, Risk Factors, Outcomes and Clinical Management of BK Viremia in the Modern Era of Kidney Transplantation
J. Kim
Toronto General Hospital, Toronto, ON, Canada
*Purpose: BK viremia is endemic among kidney transplant recipients (KTR). Previous work has not compared the incidence, risk factors, and outcomes of any vs. clinically…
2019 American Transplant Congress
Effects of IVIG Therapy and FcγR Polymorphisms on BK Virus Nephropathy in Kidney Transplant Recipients
D. I. Min¹, Y. Chang², T. Shah³
¹Western Univ of Health Sciences, Los Angeles, CA, ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ³St. Vincent Medical Center, Los Angeles, CA
*Purpose: BK Virus Nephropathy (BKVN) is a major complication in kidney transplant patients. Although standard treatment for BKVN is immunosuppression reduction and/or using leflunomide, studies…
2019 American Transplant Congress
Tandem Mass Tags Based Liquid Chromatography/ Mass Spectrometry Analysis of Quantitative Proteomic Changes in Renal Allograft Biopsies with Polyomavirus BK Nephropathy
F. Fang, P. Liu, L. Song, Y. Zhao, G. Zeng, G. Tseng, K. Xiao, P. Randhawa
University of Pittsburgh, Pittsburgh, PA
*Purpose: Transcriptomics analyses have not generated reliable means to distinguish T-cell mediated rejection (TCMR) from BK virus nephropathy (BKVN). Proteomics-based approaches deserve further exploration since…