Articles tagged "Polyma virus"

2019 American Transplant Congress
Deceased-Donor Acute Kidney Injury Associates with Less BK Viremia in Kidney Transplant Recipients
I. E. Hall, P. P. Reese, S. G. Mansour, S. Mohan, M. D. Doshi, Y. Jia, H. R. Thiessen-Philbrook, E. Akalin, M. N. Harhay, T. Muthukumar, B. Schröppel, P. Singh, F. L. Weng, J. S. Bromberg, C. R. Parikh
For the DDS Consortium, Baltimore, MD
*Purpose: BK viremia (BKV) and polyomavirus nephropathy are kidney transplant complications that contribute to morbidity and graft loss, and prior studies suggest they may be…
2019 American Transplant Congress
Prolonged Fluoroquinolone Prophylaxis to Prevent BK Viremia in Kidney Transplant Recipients
S. A. Muhsin¹, S. J. Ripley², M. L. Jacobs³, K. Safa¹, D. M. Wojciechowski¹
¹Nephrology Division, MGH, Boston, MA, ²Cancer Center, MGH, Boston, MA, ³Wake Forest University School of Medicine, Winston-Salem, NC
*Purpose: Prophylaxis for kidney transplant recipients has successfully lowered early incidence of infections such as CMV. However, there are no approved agents for the prevention…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA in Urine Identifies BKVN with Graft Injury in BK Viruria Kidney Transplant Recipients
G. Huang¹, X. Chen¹, S. Yang², W. Chen², P. Chen³, X. Hou⁴, T. Jiang⁵, H. Liu⁵, X. Li⁵, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of clinical laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁴Guangzhou KingMed Center for Clinical Laboratory Co.,Ltd., Guangzhou, China, ⁵Research and Development, AlloDx Biotech Co.Ltd., Suzhou, China
*Purpose: BK Polyomavirus nephropathy (BKVN) is an important cause of dysfunction and failure of renal transplants. Elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the…
2019 American Transplant Congress
Polyomavirus Genotypes In Renal Transplant Recipients In The United States
N. Khoury¹, C. Thongprayoon², N. Leeaphorn³, J. Bruminhent⁴, W. Cheungpasitporn⁵
¹Henry Ford Transplant Institute, Detroit, MI, ²Mayo Clinic, Rochester, MN, ³University of Missouri, Kansas, MO, ⁴Mahidol University, Bangkok, Thailand, ⁵University of Mississippi, Jackson, MS
*Purpose: BK Polyomavirus (BKV) subtypes and subgroups present uneven geographical distribution, suggesting a potential relationship with ethnicity. In the United States where there is a…
2019 American Transplant Congress
The Complexity of T Cell-Mediated Rejection Scenarios: Identifying BK in Biopsies with TCMR
P. F. Halloran and The INTERCOMEX Investigators¹, G. Gupta², J. Reeve³
¹University of Alberta, Edmonton AB, AB, Canada, ²Virginia Commonwealth University, Richmond, VA, ³Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: Some transplanted kidneys have concomitant T cell-mediated rejection (TCMR) and BK virus nephropathy (BK). The histologic diagnosis in BK sometimes overlooks the TCMR component,…
2019 American Transplant Congress
Cidofovir for BK Nephropathy Rescue Treatment: A Single Center Experience
J. Slatinska¹, E. Honsova², T. Rohal¹, A. Slavcev³, P. Hruba⁴, O. Viklicky¹
¹Nephrology, IKEM, Prague, Czech Republic, ²Pathology, IKEM, Prague, Czech Republic, ³Immunology, IKEM, Prague, Czech Republic, ⁴Transplant Laboratory, IKEM, Prague, Czech Republic
*Purpose: Cidofovir is a potentially nephrotoxic antiviral drug used primarily as a treatment for CMV retinitis however due to its potent antiviral effects has been…
2019 American Transplant Congress
Predictors of Response to Intravenous Immunoglobulin for Treatment of Polyoma Nephropathy
S. Sethi, A. Vo, A. Peng, R. Najjar, K. Lim, S. Jordan, E. Huang
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: BK nephropathy is an important cause of allograft dysfunction or loss. IVIg is hypothesized to be effective by providing passive immunity to BK virus…
2019 American Transplant Congress
Evaluation Of BK Polyomavirus Monitoring And Management In Kidney Transplant Recipients
M. Tomeczkowicz, S. Mondal, N. Sulejmani, B. Summers, T. Larson, A. Jantz
Henry Ford Hospital, Detroit, MI
*Purpose: BK polyomavirus (BKV) is an opportunistic infection that can lead to BKV nephropathy and premature graft loss within the first year post-transplant. The mainstay…
2019 American Transplant Congress
Increasing Net Immunosuppression after BK Viremia
L. Cotiguala, A. Masood, J. Park, A. Naik
University of Michigan, Ann Arbor, MI
*Purpose: BK viremia is associated with inferior kidney allograft outcomes. Typical treatment involves reduction in immunosuppression. However reduction in immunosuppression is also likely to lead…
2019 American Transplant Congress
Low Specific Gravity Of First Morning Urine Predicts Bkvn in Kidney Transplant Recipients With Bk Viruria
G. Huang¹, X. Chen¹, Z. Wang², Y. Nuertai², W. Chen³, S. Yang³, P. Chen⁴, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Clinical Medicine, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China, ³Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁴Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: BK Polyomavirus nephropathy (BKVN) is an important cause of dysfunction and failure of renal transplants. BKV usually infects urinary tract retrogradely. The collecting duct…