2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
1University Health Network, Toronto, ON, Canada; 2SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…2017 American Transplant Congress
Autologous Expanded Tregs and Porcine Hematopoietic Cells to Prolong Xenogeneic Pig Skin Graft Acceptance in Baboons.
Background: Mixed chimerism (MC) has been shown to induce tolerance to allogeneic organs and has shown promise for application to xenotransplants, although long-term tolerance has…2017 American Transplant Congress
Addition of hEPCR.hCD55.hTFPI.hCD47 Modulates Multi-Lineage Cell Sequestration and Coagulation Activation by GalTKO.hCD46 Transgenic Pig Livers Perfused Ex Vivo with Human Blood.
PurposeThe sequestration of multiple hematopoietic cell lineages and inappropriate coagulation cascade activation is associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate…2017 American Transplant Congress
Prolonged Survival with Co-Stimulatory Blockade Based Immunosuppression in Pig-to-Primate Liver Xenotransplantation.
Massachusetts General Hospital, Boston, MA
Background: Since the first attempt in 1968, survival following pig-to-baboon liver xenotransplantation (LXT) has been limited to <9-days due to a lethal coagulopathy. To improve…2017 American Transplant Congress
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…2017 American Transplant Congress
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…2017 American Transplant Congress
D-Dimer Level, in Association with Humoral Responses, Negatively Correlates with Survival of Porcine Islet Grafts in Nonhuman Primates with Immunosuppression.
Background: Several immunosuppression (IS) regimens achieve long-term graft survival in nonhuman primates (NHPs) after porcine islet transplantation (PITx), but their success rates vary. To understand…2017 American Transplant Congress
Transient High Dose Tacrolimus Allows Tolerance of a Vascularized Composite Allograft Tolerance Across a Full MHC Mismatch.
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD
Purpose: The achievement of tolerance in Vascularized composite allografts (VCA) could avoid the risks of immunosuppression in this setting. We investigated strategies for tolerance induction…2017 American Transplant Congress
A Swine for Human MHC Class I Swap: Implications for Xenotransplantation.
Background: Xenotransplantation is a potential supply-side solution to the growing need for life-saving transplantable organs, but it was not until the recent advances in genetic…2017 American Transplant Congress
Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocytes Viability and Albumin Secretion.
Aim: Acute liver failure carries a very high mortality and transplantation of encapsulated pig hepatocytes might temporarily compensate the metabolic functions until the dysfunctional liver…
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