- 2019 American Transplant Congress - Development and Validation of a Capillary Blood Mitra-Based Assay for the Quantitative Determination of Advagraf® Concentrations in Transplant Patients*Purpose: Therapeutic drug monitoring of tacrolimus (TAC) requires venepuncture blood samples taken by specialists, requiring patients to attend an outpatient clinic; this can be inconvenient…
- 2019 American Transplant Congress - The Comparative Safety and Efficacy of Direct Acting Oral Anticoagulants Relative to Warfarin Following Liver Transplantation- Mount Sinai Hospital, New York, NY *Purpose: This study describes the comparative safety and efficacy of direct acting oral anticoagulants (DOACs) relative to warfarin following liver transplantation, at a large academic…
- 2019 American Transplant Congress - Impact of Liver Recipient Genotype on Tacrolimus*Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…
- 2019 American Transplant Congress - A Clinical Pharmacogenetic Model to Predict the Efficacy of Sirolimus during the Early Administration in Renal Transplant Recipients- No.300 Guangzhou Road of Nanjing, Nanjing, China *Purpose: This study was to develop a clinical pharmacogenetic model to predict the efficacy of sirolimus during the early administration in renal transplant recipients. 70…
- 2018 American Transplant Congress - Association of CYP3A5*3*6*7 Metabolic Composites to Tacrolimus Pharmacokinetics in African American and Caucasian Renal Transplant RecipientsBackground: Interpatient variability in tacrolimus pharmacokinetics(PK) is due primarily to metabolism by cytochrome P-450 3A5(CYP3A5) isoenzymes. African Americans(AA) require higher tacrolimus doses to achieve comparable…
- 2018 American Transplant Congress - The Providers Can't Let Go! An Analysis of an RN Driven Tacrolimus Dose Adjustment ProtocolIntroduction: Tacrolimus (FK) dose adjustment is frequently performed by non-MD staff. Standard protocols to evaluate the ability of non-providers to maintain pts within a goal…
- 2018 American Transplant Congress - Institution-Based, Pharmacist-Managed Anticoagulation in Patients with a Left Ventricular Assist DeviceLong-term anticoagulation with warfarin is required for patients with left ventricular assist devices (LVADs). There is limited data of time in therapeutic range (TTR) in…
- 2018 American Transplant Congress - Single-Dose Pharmacokinetics and Pharmacodynamics of Belatacept in Adolescent Kidney Transplant RecipientsPurpose: To assess the pharmacokinetics (PK) and pharmacodynamic (PD) effect of a single dose of belatacept (bela) administered to adolescent kidney transplant recipients (KTR).Methods: In…
- 2018 American Transplant Congress - High Tacrolimus Variability is Associated with Worse Outcomes in Pediatric Renal Transplant Recipients- Montefiore Medical Center, Bronx, NY. Background: Subtherapeutic tacrolimus trough concentrations are associated with donor specific antibody (DSA), acute rejection and shortened graft survival. The role of intrapatient variability in tacrolimus…
- 2018 American Transplant Congress - The Effect of Tacrolimus Trough Level and Intrapatient Variability on the Transplant Outcomes in Kidney TransplantationBackground: Tacrolimus (TAC) is the mainstay of immunosuppression for kidney transplantation (KT). Although TAC has a narrow therapeutic index, appropriate trough concentrations of TAC have…
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