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American Transplant Congress abstracts

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Articles tagged "Pharmacokinetics"

  • 2022 American Transplant Congress

    Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations Are Associated with the Stool Bacterial Microbiome

    P. A. Jacobson1, A. Saqr1, B. Carlson1, C. Staley2, A. Rashidi3, S. Holtan3, M. Al-Kofahi1, T. Kaiser2, M. MacMillan4, J. Young5, N. El Jurdi3, D. Weisdorf3, A. Khoruts6

    1Univ of MN, College of Pharmacy, Minneapolis, MN, 2Univ of MN, Dept of Surgery, Minneapolis, MN, 3Univ of MN, Divison of Heme/Onc Transplant, Minneapolis, MN, 4Univ of MN, Pediatric Heme/Onc Transplant, Minneapolis, MN, 5Univ of MN, Divison of Infectious Diseases, Minneapolis, MN, 6Univ of MN, Division of Gastroenterology, Hepatology and Nutrition, Minneapolis, MN

    *Purpose: Mycophenolate mofetil (MMF) is an important immunosuppressant used after allogeneic hematopoietic cell transplant (HCT). Blood concentrations of mycophenolic acid (MPA) are highly variable and…
  • 2022 American Transplant Congress

    Impact of Cyp 3a5 Genotype on Lcp Tacrolimus Dosing and Monitoring in Kidney Transplantation

    D. J. Taber, T. Carcella, N. Patel, F. Bartlett, A. Posadas, V. Rao, M. Casey, V. Rohan, D. Dubay, D. Taber

    Med Univ of South Carolina, Charleston, SC

    *Purpose: LCP Tacrolimus has a recommended de novo starting dose of 0.14 mg/kg/day in kidney transplantation (KTR). There is limited data on the influence of…
  • 2022 American Transplant Congress

    The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation

    K. Evans1, K. Beermann1, H. Lee2, M. Harris1, C. W. Frankel3, H. Berry1, H. Ali3

    1Pharmacy, Duke Health, Durham, NC, 2Biostatistics and Bioinformatics, Duke University, Durham, NC, 3Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC

    *Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…
  • 2022 American Transplant Congress

    Predicted Performance of Bayesian-Based Precision Dosing Software for Tacrolimus

    A. Seghezzo1, J. Kerr1, A. Gupta2, A. Ta2, L. Powell2, A. Feist3

    1University of California San Diego Health, San Diego, CA, 2PrecisePK, San Diego, CA, 3UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA

    *Purpose: Bayesian-based precision dosing software (BPDS) has been utilized for therapeutic drug monitoring to optimize medication use. However, BPDS for tacrolimus (TAC) is not routinely…
  • 2022 American Transplant Congress

    Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients

    R. Gordon1, K. Dewey1, R. Jariwala1, B. Yen1, J. Kukreja2, S. Hays2, J. Singer2, R. Florez1

    1Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA

    *Purpose: We hypothesized that crushed posaconazole delayed release (POSA DR) tablets can reach therapeutic levels in lung transplant recipients who are at risk for invasive…
  • 2021 American Transplant Congress

    Avoiding Tacrolimus Under- and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial

    M. I. Francke1, L. M. Andrews2, H. L. Le2, J. van de Wetering1, M. C. Clahsen-van Groningen3, T. van Gelder4, R. H. van Schaik5, B. van der Holt6, B. C. de Winter2, D. A. Hesselink1

    1Internal medicine, nephrology and transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 2Hospital Pharmacy, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Pathology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, 5Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 6Hematology, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Bodyweight-based tacrolimus dosing followed by therapeutic drug monitoring is standard clinical care after renal transplantation. However, after transplantation, a meagre 38% of patients is…
  • 2021 American Transplant Congress

    Evaluation of Empiric Extended-Release Tacrolimus Dosing in Adult Kidney Transplant Recipients

    C. Patel, S. Lee, D. M. Salerno, N. W. Lange, J. Hedvat

    Pharmacy, NewYork-Presbyterian Hospital, New York, NY

    *Purpose: Envarsus XR® (extended-release [XR] tacrolimus) is the standard of care tacrolimus formulation at our center for de novo maintenance immunosuppression in adult kidney transplant…
  • 2021 American Transplant Congress

    Quantifying the Interaction Between Posaconazole and Tacrolimus in Liver Transplant Recipients: A Practical Approach

    B. Lane1, U. Kaszubski1, A. Freeman1, B. Wise1, L. Hutchinson1, M. Janusek1, G. Therapondos2, H. Bohorquez3, S. Anders1

    1Pharmacy, Ochsner Medical Center, New Orleans, LA, 2Hepatology, Ochsner Medical Center, New Orleans, LA, 3Transplant Surgery, Ochsner Medical Center, New Orleans, LA

    *Purpose: The interaction between tacrolimus (FK) and posaconazole (POSA) is well documented, however the extent of this interaction and the practical management has yet to…
  • 2021 American Transplant Congress

    Therapeutic Enoxaparin Dosing in Lung Transplant Recipients

    S. Finder, M. Morrison, K. B. Harrison, S. A. Heeney

    Vanderbilt University Medical Center, Nashville, TN

    *Purpose: Enoxaparin 1 mg/kg subcutaneously every 12 hours for therapeutic anticoagulation is known to increase rates of supratherapeutic anti-Xa levels in lung transplant recipients (LTRs).…
  • 2021 American Transplant Congress

    Evaluate the Effect of Cresemba (isavuconazonium Sulfate) Capsule and Noxafil (posaconazole) Delayed Release Tablets on Tacrolimus Dose to Concentration (D/C) Ratios in Lung Transplant Recipients

    H. Sweiss1, E. Kincaide1, D. Levine2, R. Hall1

    1University Health, San Antonio, Department of Pharmacotherapy and Pharmacy Services, The University of Texas at Austin, Pharmacotherapy Division, College of Pharmacy, San Antonio, TX, 2University Health, San Antonio, University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: Evaluate the effect of Cresemba (isavuconazonium sulfate) capsule and Noxafil (posaconazole) delayed release tablet on tacrolimus dose to concentration (D/C) ratio in lung transplant.*Methods:…
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