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Articles tagged "Pediatric"

  • 2017 American Transplant Congress

    Refinement of an Old Faithful: A Standardized Flow Cytometry Approach to Measure Donor-Recipient Alloreactivity (a Pilot Study).

    A. Halpin,1 M. Sosniuk,1 S. Urschel,1 P. Campbell,2 I. Larsen,1 L. West.1

    1Pediatrics, Alberta Transplant Institute, Canadian National Transplant Reseach Program, University of Alberta, Edmonton, Canada; 2Lab Medicine and Pathology, University of Alberta, Edmonton, Canada

    Purpose: Donor-specific antibody (DSA) and antibody (Ab)-mediated rejection are challenges in long-term outcomes and limit re-transplantation. Sensitizing events such as homografts in surgical procedures, assist…
  • 2017 American Transplant Congress

    Rabbit Anti-Human Thymocyte Immunoglobulin (rATG) for Rescue Treatment of Chronic Antibody-Mediated Rejection (cAMR) After Pediatric Kidney Transplantation.

    L. Pape, T. Ahlenstiel-Grunow, J. Drube, M. Kreuzer, C. Lerch, N. Kanzelmeyer, S. Wente, I. Hennies, Y. Cihan.

    Pediatric Nephrology, Hannover Medical School, Hannover, Germany

    Background. Chronic antibody-mediated rejection (cAMR) is the leading cause of long-term graft loss after kidney transplantation. Treatment guidelines include rituximab, immunoadsorption, immunoglobulins and/or bortezomib, but…
  • 2016 American Transplant Congress

    The Use of Thromboelastography (TEG) in Preoperative Pediatric Liver Transplantation to Predict Postoperative Thrombotic Complications.

    K. Curiel,1 B. Wicklund,2 K. Gonzalez,1 W. Andrews,1 V. Fioravanti,1 R. Hendrickson.1

    1Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; 2Department of Hematology, Children's Mercy Hospital, Kansas City, MO.

    Introduction: Little data exists in the use of thromboelastography (TEG) in pediatric liver transplantation. In 2011 we implemented pre-transplant TEGs for patients listed for liver…
  • 2016 American Transplant Congress

    Barriers to Living Donor Kidney Transplant in the Pediatric Population.

    S. Taormina,1 M. Galloway,2 A. Jain.3

    1Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI; 2Department of Psychiatry and Behavioral Neurosciences and Department of Anesthesiology, Wayne State University School of Medicine, Detroit, MI; 3Division of Pediatric Nephrology and Hypertension, Wayne State University School of Medicine, Detroit, MI.

    Objective:A shift from living donor transplants to deceased donor transplants has been noted nationwide and is more prominent at some centers than others. Our objective…
  • 2016 American Transplant Congress

    Outcome of Partial Reconstruction of Multiple Hepatic Arteries in Pediatric Living Donor Liver Transplantation Using Left Lateral Section Grafts.

    K. Lee, K. Kim, S. Kim, J. Lee, J. Lee, N. Lee, C. Cho, S. Lee, G. Choi, C. Kwon, J.-W. Joh, S.-K. Lee.

    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

    In pediatric end-stage liver disease patients, the use of partial liver grafts from adult living donors has been increasing for liver transplantation due to a…
  • 2016 American Transplant Congress

    Pediatric Heart Transplantation Across a Positive Cross-Match Is Associated with High Rates of AMR but No Difference in Short Term Graft Loss, Dysfunction and Death (CTOTC-04 study).

    S. Webber,1 L. Addonizio,2 E. Blume,3 A. Dipchand,4 R. Shaddy,5 B. Feingold,6 C. Canter,7 D. Hsu,8 W. Mahle,9 A. Zeevi,6 K. Much,10 D. Ikle,10 H. Diop,11 J. Odim, MD, PhD, for CTOTC-04 Investigators.11

    1Vanderbilt, Nashville; 2Columbia Univ., NYC; 3Boston Children's, Boston; 4Sick Kids, Toronto, Canada; 5CHOP, Philadelphia; 6CHP of UPMC, Pittsburgh; 7Washington Univ., St. Louis; 8Children's Hospital, Montefiore, NYC; 9CHOA, Atlanta; 10Rho, Chapel Hill; 11NIAID/NIH, Bethesda.

    Sensitization is common in pediatric heart transplant (HT) candidates. Waitlist mortality is high if a prospective -ve CDC-crossmatch (XM) is required, but HT across a…
  • 2016 American Transplant Congress

    High-Risk Age Window for Graft Loss in Pediatric Lung and Heart Transplant Recipients.

    B. Orandi, X. Luo, K. Van Arendonk, R. Higgins, D. Segev.

    Johns Hopkins University, Baltimore.

    Late adolescence and early adulthood is a high-risk age window for pediatric kidney graft loss, though not for pediatric liver graft loss. It is unknown…
  • 2016 American Transplant Congress

    Graft Survival of Steroid-Avoidance Protocols in Pediatric Kidney Transplantation[mdash]A Propensity Score Analysis.

    E. Nehus,1 Y. Wang,2 B. Lu,3 C. Liu,2 M. Macaluso,2 M.-O. Kim.2

    1Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 2Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 3Division of Biostatistics, The Ohio State University, Columbus, OH.

    Purpose: This study investigated whether steroid avoidance-protocols adversely influence allograft survival among pediatric kidney transplant recipients at high levels of immunologic risk.Methods: A retrospective cohort…
  • 2016 American Transplant Congress

    Initial Evaluation of Use of NAT in Assignment of CMV and EBV Infection Status in Children Awaiting Solid Organ Transplant.

    C. Burton, Y. Tong, J. Preiksaitis.

    Medicine, University of Alberta, Edmonton, Canada.

    Purpose: The presence of passive antibodies, transfusion-acquired or maternal in infants, can make serologic determination of pre-transplant CMV and EBV status in children unreliable. We…
  • 2016 American Transplant Congress

    Ideal Outcome After Liver Transplantation: An Exploratory Study Using Machine Learning Analyses to Leverage Long-Term Registry Data from Studies in Pediatric Liver Transplantation (SPLIT).

    E. Hsu,1 M. Shaffer,1,2 R. Anand,3 V. Ng,4 J. Bucuvalas.5

    1University of Washington School of Medicine, Seattle, WA; 2Children's Core for Biomedical Statistics, Center for Clinical and Translational Research, Seattle Children's Hospital, Seattle, WA; 3The EMMES Corporation, Rockville, MD; 4The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada; 5Cincinnati Children's Hospital and Medical Center, Cincinnati, OH.

    We analyzed the Studies in Pediatric Liver Transplantation (SPLIT) registry dataset using heat map and random forests analyses (RFA) to determine if ideal outcome (IO)…
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