Articles tagged "Pediatric"

2022 American Transplant Congress
Evaluation of Different Initial Tacrolimus Dosing Regimens in Pediatric Post-Liver Transplantation
A. F. Alghanem¹, A. Alsmari¹, H. Joharji²
¹Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia, ²Pharmaceutical Care, King Faisal Specialized Hospital and Research Center, Riyadh, Saudi Arabia
*Purpose: Tacrolimus is an immunosuppressant used in post-liver transplantation, has wide pharmacokinetic variability, particularly in pediatric patients. Therefore, this study aimed to evaluate different weight-based…
2022 American Transplant Congress
Transition Program for Young Adults with Solid Organ Transplant a Single Center Protocol
H. Y. Lee
Program for Pediatric Cardiomyopathy, Heart Failure, and Cardiac Transplantation, Columbia University Irving Medical Center, New York, NY
*Purpose: The transition process for young adult solid organ transplant patient is an important clinical milestone in a transplant patient's life. Evidenced based research demonstrates…
2022 American Transplant Congress
Effect of Schisandra Sphenanthera Extract on Pharmacokinetics of Tacrolimus in Pediatric Renal Transplant Recipients
J. Jiang¹, H. Zhang¹, X. Su¹, S. Wu¹, Y. Chen², W. Chen², J. Li², C. Wu², L. Yang², L. Liu², C. Wang²
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Wuzhi tablet (Schisandra sphenanthera extract) is a promising tacrolimus-sparing agent in adult renal transplant recipients, while its effect in pediatric recipients remains unclear. The…
2022 American Transplant Congress
Pre-Emptive Rituximab to Prevent Post Transplant Lymphoproliferative Disorder (PTLD) in Pediatric Kidney Transplant Recipients with EBV DNAemia: A Case Series from the Pediatric Nephrology Research Consortium (PNRC)
I. Ashoor¹, S. Ranabothu², S. Al-Akash³, A. Moudgil⁴, Y. Shi⁴, S. Kizilbash⁵, D. Puliyanda⁶, V. Dharnidharka⁷
¹LSU Health Sciences Center New Orleans, New Orleans, LA, ²Arkansas Children's Hospital, Little Rock, AR, ³Driscoll Children's Hospital, Corpus Christie, TX, ⁴Children's National Medical Center, Washington, DC, ⁵University of Minnesota Medical Center, Minneapolis, MN, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Washington University in St. Louis, St Louis, MO
*Purpose: The use of Rituximab (RTX) to prevent PTLD in patients with EBV DNAemia is an established strategy in hematopoietic stem cell transplants, but with…
2022 American Transplant Congress
Increased Waitlist Mortality in Pediatric Liver Transplant Candidates with Greater Distance from Transplant Center
C. X. Qin, T. Ishaque, S. M. Frey, A. B. Massie, A. M. Cameron, D. L. Segev, E. A. King
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Greater distance from transplant center in adult liver transplant (LT) candidates is associated with increased waitlist mortality. Pediatric LT candidates have higher waitlist mortality…
2022 American Transplant Congress
Data-Driven Clustering Distinguishes Infection from Rejection During Hospital Admissions Following Pediatric Lung Transplantation
C. D. Britto¹, D. Boyer², G. Visner³, G. Priebe⁴, L. Midyat³
¹Department of Pediatrics, Boston Children's Hospital, Boston, MA, ²Division of Pulmonary Medicine, Nationwide Children's Hospital, Ohio, MA, ³Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, ⁴Department of Anesthesiology, Critical Care and Pain Medicine, Division of Infectious Disease, Boston Children's Hospital, Boston, MA
*Purpose: When lung transplantation patients are admitted with respiratory symptoms, distinguishing between episodes of infection and rejection is central to determining immunosuppressive management.*Methods: Data comprising…
2022 American Transplant Congress
Baseline Trends in Tacrolimus Intrapatient Variability in Pediatric and Young Adult Kidney Transplant Recipients
K. Piburn¹, L. Maestretti², M. V. Patton², A. M. McGrath², O. S. Indridason³, A. Chaudhuri¹, P. Grimm¹, V. Sigurjonsdottir¹
¹Pediatric Nephrology, Stanford University, Palo Alto, CA, ²Pediatric Kidney Transplant, Lucile Packard Children's Hospital, Palo Alto, CA, ³Division of Nephrology, Landspitali – the National University Hospital of Iceland, Reykjavik, Iceland
*Purpose: High tacrolimus intrapatient variability (IPV) is a known risk factor for poor graft outcomes in kidney transplantation. Baseline trends in tacrolimus IPV have not…
2022 American Transplant Congress
Long Term Analysis of Pediatric En-Bloc Kidney Transplantation: A Single Center Experience
H. H. Patel¹, P. Di Cocco², J. Almario², A. Fratti², S. Akshelyan², E. Benedetti², I. Tzvetanov², M. Spaggiari²
¹University of Missouri-Kansas City School of Medicine, Kansas City, MO, ²University of Illinois at Chicago, Chicago, IL
*Purpose: Pediatric en-bloc kidney transplantations for adult recipients are uncommonly performed due to unique donor characteristics, the technical challenge of the operation, and potential surgical…
2022 American Transplant Congress
Non-HLA Antibodies to G Protein-Coupled Receptors and Allograft Survival in Pediatric Kidney Transplant Recipients: Short- and Long-Term Outcomes
M. Pearl¹, L. Chen¹, P. Weng¹, E. T. Chambers², E. F. Reed³
¹UCLA, Los Angeles, CA, ²Pediatrics, Duke University, Durham, NC, ³Univ of California LA, Los Angeles, CA
*Purpose: We have recently shown that the non-HLA antibodies to angiotensin II type 1 receptor (AT1R-Ab) and endothelin-1 type A receptor (ETAR-Ab) are prevalent and…
2022 American Transplant Congress
Outcomes in Pediatric Intestinal Retransplantation
E. J. Lee¹, G. Mazariegos¹, K. Soltys¹, G. Bond¹, A. Ganoza¹, J. Rudolph², S. Horslen², R. Sindhi¹, A. Khanna¹
¹Transplant Surgery, UPMC, Pittsburgh, PA, ²Division of Gastroenterology, Hepatology and Nutrition,, UPMC, Pittsburgh, PA
*Purpose: Historically, intestinal retransplantation (Re-ITx) has been associated with high morbidity and mortality.*Methods: Retrospective chart review of patients who underwent Re-ITx at our institution between…