Articles tagged "Pediatric"

2018 American Transplant Congress
T Cell Exhaustion Contributes to Operational Tolerance of Liver Allografts in Pediatric Liver Transplant Recipients
B. Ramaswami,¹ M. Marrari,² O. Yoshida,⁵ X. Guo,³ W. Hoffman,³ C. Bentlejewski,² D. Metes,¹ A. Demetris,^1,2 A. Zeevi,² A. Thomson,¹ G. Mazariegos,⁴ G. Chalasani.^1,3
¹Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ²Pathology, University of Pittsburgh, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA; ⁴Children's Hospital, University of Pittsburgh, Pittsburgh, PA; ⁵Gastroenterology, Ehime University Graduate School of Medicine, Toon-shi, Ehime-ken, Japan.
Operational tolerance in the absence of immunosuppression can be successfully attained in pediatric liver transplant recipients. Although DSA are observed in a proportion of operationally…
2018 American Transplant Congress
Renal Transplant Outcomes in Recipients Weighing 8-10 Kilograms
P. Singer, Y. Tseng, C. Sethna, L. Castellanos-Reyes, E. Molmenti, A. Fahmy, E. Grodstein, L. Teperman.
Pediatric Nephrology and Transplantation, Cohen Children's Medical Center, New Hyde Park, NY.
Background: Renal transplant is the optimal treatment for children with end-stage renal disease (ESRD). Most centers require a minimum weight of about 10 kg for…
2018 American Transplant Congress
Disparities in Re-Transplantation among Pediatric Renal Transplant Recipients with Graft Failure
M. Basu,¹ R. Patzer,¹ R. George.^1,2
¹Emory University School of Medicine, Atlanta, GA; ²Pediatric Nephrology, Children's Healthcare of Atlanta, Atlanta, GA.
Background: While gender and racial disparities in access to transplantation have been reported among pediatric patients, few studies have investigated if these disparities exist in…
2018 American Transplant Congress
Increasing Obesity Prevalence in the United States Pediatric End-Stage Renal Disease Population
B. Shelton,¹ P. MacLennan,¹ R. Reed,¹ M. Mustian,¹ D. McWilliams,¹ D. Sawinski,² J. Locke.¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL; ²Medicine, University of Pennsylvania, Philadelphia, PA.
Background: Obesity prevalence among children in the United States (US) is high, but the rate of increase has slowed over time. Among pediatric end-stage renal…
2018 American Transplant Congress
Wait Times for Pediatric Liver Transplantation and the Impact of PELD/MELD Exception
K. Khan,¹ C. Desai,² F. Thomas,¹ K. Alexander.¹
¹Transplant Institute, MedStar Georgetown University Hospital, Washington, DC; ²Surgery, University of North Carolina, Chapel Hill, NC.
Background:In order to even the playing field for patients without liver disease that nevertheless are in urgent need for a liver graft the United Network…
2018 American Transplant Congress
Building a Third-Party VST Bank from Scratch- The Cincinnati Experience
A. S. Nelson,¹ D. Heyenbruch,² X. Zhu,³ S. M. Davies,¹ C. Lutzko,³ C. Bollard,⁴ P. Hanley,⁴ T. Leemhuis,² L. Danziger-Isakov,⁵ M. S. Grimley.¹
¹Bone Marrow Transplant & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²Hoxworth Blood Center, Univeristy of Cincinnati, Cincinnati, OH; ³Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ⁴Proram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington, DC; ⁵Depatment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…
2018 American Transplant Congress
Worsening Racial/Ethnic Disparities in Pediatric Kidney Transplant Outcomes in the US
T. Purnell, X. Luo, L. Cooper, D. Crews, K. Covarrubias, A. Massie, D. Segev.
Johns Hopkins, Baltimore.
Purpose: We recently demonstrated narrowed racial/ethnic disparities in adult kidney transplant (KT) outcomes in the US. The goal of this study was to examine twenty-year…
2018 American Transplant Congress
Medication Adherence: Does Where You Live Matter?
S. Wadhwani,¹ S. Taylor,¹ C. Brokamp,¹ W. Guo,¹ E. Shemesh,² J. Bucuvalas.¹
¹Cincinnati Children's Hospital Medical Center, Cincinnati; ²Mount Sinai School of Medicine, New York.
Background & Objectives: Medication non-adherence remains problematic in pediatric liver transplant (LT)[mdash]estimates suggest that up to 53% of adolescents are non-adherent. We leveraged data from…
2018 American Transplant Congress
Long-Term Follow-Up of Pediatric Kidney Recipients Who Received Alemtuzumab Induction
D. Harriman, A. Chen, J. Rogers, R. Stratta, G. Orlando, A. South, J-.J. Lin, A. Farney.
Surgery, Pediatrics, Cardiovascular Sciences Center, Wake Forest Baptist Medical Center, Winston-Salem, NC.
Introduction: Experience with alemtuzumab (alem) depleting antibody induction has rarely been studied in the pediatric population, and reports that exist have limited follow-up. The purpose…
2018 American Transplant Congress
Utilization of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients by Era
M. Meyers,¹ J. Shults,¹ B. Laskin,¹ P. Porrett,² M. Levine,² P. Abt,² S. Amaral,^1,2 D. Goldberg.²
¹Children's Hospital of Philadelphia, Philadelphia; ²University of Pennsylvania, Philadelphia.
Purpose: Donors labeled Public Health Service Increased Risk (PHS-IR) continue to rise due to opioid abuse and expanding criteria defining 'increased-risk.' Many PHS-IR donors are…