Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Background: Renal transplant is the optimal treatment for children with end-stage renal disease (ESRD). Most centers require a minimum weight of about 10 kg for transplantation. However, this may result in months of additional wait time, with prolonged associated risk.
Objective:We compared the outcomes of children weighing between 8 to 10kg at time of transplant to those weighing 10 to 13 kg to assess the risk associated with low-weight transplantation.
Methods: A retrospective analysis of transplants between January 2000-March 2014 was conducted using the UNOS database. Baseline characteristics and transplant outcomes of children 8-10 kg were compared to those 10-13 kg. Baseline characteristics were compared using t-test for continuous variables and X2 for categorical variables. Outcomes were evaluated using X2 and Cox regression. Outcome variables were delayed graft function, acute rejection at 6 months and 1 year, and graft failure at 1 and 5 years.
Results: Of 1049 children, 245 (23%) were under 10kg and 804 (77%) were 10-13 kg. There were no significant differences in gender, race, donor source (living or deceased), or underlying disease (glomerular/systemic vs. structural).
There was no significant difference in frequency of delayed function, thrombosis, acute rejection or graft failure at 1 and 5 years between the groups.
|≥8kg to <10kg(%)||≥10g to <13kg(%)||p-value|
|Acute rejection by 6 mos.||4.5||6.6||0.36|
|Acute rejection by 1 yr||6.9||8.5||0.67|
|Graft failure by 1 yr||6.9||4.6||0.15|
|Graft failure by 5 yrs||11.8||9.0||0.19|
In regression analysis, no significant differences in 1 and 5 year rates of graft failure were identified between the weight groups when controlled for age, height, gender, race, donor source, pre-transplant dialysis and cause of renal failure.
|HR [95% CI]||p-value|
|Graft failure by 1 yr||1.26 [0.58,2.70]||0.56|
|Graft failure by 5 yrs||1.40[0.82, 2.40]||0.22|
Conclusion: There was no significant difference in measured outcomes between children who received kidney transplants at 8 to <10 kg compared to children 10-13kg.
CITATION INFORMATION: Singer P., Tseng Y., Sethna C., Castellanos-Reyes L., Molmenti E., Fahmy A., Grodstein E., Teperman L. Renal Transplant Outcomes in Recipients Weighing 8-10 Kilograms Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Singer P, Tseng Y, Sethna C, Castellanos-Reyes L, Molmenti E, Fahmy A, Grodstein E, Teperman L. Renal Transplant Outcomes in Recipients Weighing 8-10 Kilograms [abstract]. https://atcmeetingabstracts.com/abstract/renal-transplant-outcomes-in-recipients-weighing-8-10-kilograms/. Accessed July 10, 2020.
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