Articles tagged "Pediatric"

2019 American Transplant Congress
Post-Transplant Lymphoproliferative Disorders in Pediatric Renal Transplant Recipients: Case Series of 5 Patients
M. E. Araujo¹, C. Metran¹, R. Cardoso¹, G. Araujo¹, T. De Paula¹, L. Cristofani², M. F. Pereira³, D. David⁴, A. Watanabe¹
¹Pediatric Nephrology, ICr HC FMUSP, São Paulo, Brazil, ²Pediatric Oncology, ICr HC FMUSP, São Paulo, Brazil, ³Pediatric Infectology, ICr HC FMUSP, São Paulo, Brazil, ⁴Anatomopathology, HC FMUSP, São Paulo, Brazil
*Purpose: Post-transplant Lymphoproliferative Disorders (PTLD) after solid organ transplantation is a complication of chronic immunosuppression (IS) and is generally associated with Epstein Barr virus (EBV)…
2019 American Transplant Congress
Pictogram Tool to Improve Medication Adherence in Heart Transplant Families with Limited English Proficiency and Low Health Literacy
A. C. Rothkopf¹, J. Chen², N. Jasiak-Panek³, K. Le³, A. Joong⁴, L. J. Addonizio¹
¹Pediatric Cardiology, Columbia University, New York, NY, ²Department of Pharmacy, Columbia University, New York, NY, ³Department of Pharmacy, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁴Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
*Purpose: Rejection in heart transplant recipients significantly limits long-term survival, impairs quality of life, and increases both direct and indirect costs of care. Preventing rejection…
2019 American Transplant Congress
Elevated Donor Derived Cell Free DNA (dd-cfDNA) Levels in the Presence of Donor Specific Antibodies (DSA) Are a Strong Predictor of Antibody Mediated Rejection (ABMR) in Pediatric Renal Transplant Recipients
D. Puliyanda¹, R. D. Swinford², H. Pizzo¹, J. Garrison¹, I. Kim¹, A. M. De Golovine², S. Jordan¹
¹Pediatric Nephrology, Cedars-Sinai Med Ctr, Los Angeles, CA, ²Pediatric Nephrology, UTHealth, Houston, TX
*Purpose: A renal biopsy, the gold standard for the diagnosis of antibody mediated rejection (ABMR) in transplant recipients, is invasive and may be associated with…
2019 American Transplant Congress
Impact of a Novel Digital Medicine Program on Adherence and Utilization in Pediatric Transplant Patients
S. Sullivan¹, K. N. Triplett¹, C. Sacks², M. Tran², D. M. Desai³
¹Solid Organ Transplant, Children's Medical Center, Dallas, Dallas, TX, ²Proteus Digital Health, Redwood City, CA, ³Transplant Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
*Purpose: Purpose: Optimal allograft function and long-term graft survival depends on many factors, including adherence to a complex medication regimen. Methods of measuring adherence are…
2019 American Transplant Congress
HLA-DR Upregulation in Pediatric Kidney Transplant Biopsies
O. Moussa, S. Self, E. Bruner, K. Twombley
Medical University of South Carolina, Charleston, SC
*Purpose: Renal tubular epithelial cells do not typically express human leukocyte antigen DR (HLA-DR). It’s expression has been associated with different types of tubular injury…
2019 American Transplant Congress
Development and Implementation of a Pediatric Transplant Consortium
K. Soltys¹, S. K. Rassmussen², J. Squires³, R. Sindhi¹, S. Pelletier², K. Brayman², M. Angelis⁴, T. Chin⁴, R. Teaster², J. Oberholzer², R. Gonzalez-Peralta⁵, B. Friedman⁴, D. Hupp⁶, M. Mendoza⁷, P. A. Eicker⁶, J. Middleton⁷, G. Mazariegos¹
¹Transplant Surgery, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Charles O. Strickler Transplant Center, University of Virginia, Charlottesville, VA, ³Hepatology, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁴AdventHealth Transplant Institute, Florida Hospital, Orlando, FL, ⁵AdventHealth for Children, Florida Hospital, Orlando, FL, ⁶Nursing, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁷Hepatology, University of Virginia, Charlottesville, VA
*Purpose: Access to pediatric liver transplant expertise varies nationally and variability in practice leads to potential suboptimal organ utilization and outcomes. A multi-institutional collaborative was…
2019 American Transplant Congress
Transition from Pediatric to Adult Care of Kidney Transplant Recipients: A Retrospective Analysis of a French Monocentric Cohort
M. Mazloum¹, M. Charbit², O. Aubert¹, D. Anglicheau¹, A. Scemla¹, R. Salomon², P. Krug², C. Legendre¹, R. Sberro-Soussan¹
¹Adult Nephrology and Renal Transplantation Department, Necker Hospital, Paris, France, ²Pediatric Nephrology and Renal Transplantation Department, Necker Hospital, Paris, France
*Purpose: Transition refers to the dynamic process in which the patient is oriented from pediatric to adult care. In the field of kidney transplantation, transition…
2019 American Transplant Congress
Tocilizumab for Refractory Antibody-Mediated Rejection in Pediatric Kidney Transplantation
A. Dokras, C. Butler, Q. Zhang, E. Reed, R. Ettenger, P. Weng, M. Pearl
University of California, Los Angeles, Los Angeles, CA
*Purpose: IL-6 blockade may play a role in reducing human leukocyte antigen donor specific antibodies (HLA DSA) production and stabilizing allograft function. We aimed to…
2019 American Transplant Congress
High Prevalence of Allergic Disorders but No Specific Immune Phenotype Pattern in Children Awaiting Transplantation
T. B. Kim¹, Y. Avitzur², L. Ionescu¹, U. Allen², S. Mital², B. Foster³, T. Blydt-Hansen⁴, L. Hamiwka⁵, P. Birk⁶, V. Phan⁷, S. Urschel¹
¹University of Alberta, Edmonton, AB, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³McGill University, Montreal, QC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵University of Calgary, Calgary, AB, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Université de Montréal, Montreal, QC, Canada
*Purpose: Allergic disorders (AD) occur more frequently in children after transplantation (Tx) compared to healthy children, reflecting an imbalance of the immune system in the…
2019 American Transplant Congress
Racial Disparities in Documentation of Non-Adherence and Its Relation to Rejection in Pediatric Kidney Transplant Recipients
T. Melanson, J. Hogan, K. Maroney, R. Patzer, R. George
Emory University, Atlanta, GA
*Purpose: Black patients have historically been disadvantaged throughout the transplant process. Many factors impact the success of kidney transplantation, but the need for strict adherence…