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American Transplant Congress abstracts

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Articles tagged "Pediatric"

  • 2022 American Transplant Congress

    Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health

    M. Rao1, M. Amouzgar1, J. T. Harden1, M. Lapasaran1, A. Trickey1, B. Armstrong2, J. Odim3, T. Debnam3, C. Esquivel1, S. C. Bendall1, O. Martinez1, S. M. Krams1

    1Stanford University, Palo Alto, CA, 2Rho, Durham, NC, 3National Institutes of Health, Bethesda, MD

    *Purpose: Solid organ transplant is lifesaving for children with end-stage heart, liver, or kidney disease. Protection of the transplanted organ from rejection requires long-standing immunosuppression.…
  • 2022 American Transplant Congress

    Why and How We Do Native Nephrectomy in Low Weight Pediatric Kidney Transplantation Patients

    N. Celik1, B. Akyollu1, E. Arpali1, N. Akinci2, I. Bilge2, B. Kocak1

    1Division of Organ Transplantation, Koc University Hospital, Istanbul, Turkey, 2Division of Pediatric Nephrology, Koc University Hospital, Istanbul, Turkey

    *Purpose: There is no consensus about optimal timing for native nephrectomy according to the primary indication of kidney transplantation (KTx) especially in pediatric population and…
  • 2022 American Transplant Congress

    Disruption of B Cell Population is Associated with Increased Infections in Pediatric Transplant Recipients

    B. Geng, L. Loop, C. Anterasian, D. Mortazavi, J. Kitsen, C. Collins, K. Newton, E. Ingulli

    Pediatrics, UCSD Rady Children's, San Diego, CA

    *Purpose: Solid-organ transplant recipients are placed on long-term immunosuppression, preventing graft rejection but increasing the risk of infection. Pediatric transplant recipients are at increased risk…
  • 2022 American Transplant Congress

    Surveillance of Donor-Derived Cell-Free DNA Throughout Treatment of Acute Rejection in Pediatric Renal Transplant Recipients

    K. A. Klein1, E. L. Kincaide1, M. Fei2, A. M. Bell2, M. Y. Arar3, D. Ranch3

    1Pharmacotherapy Education and Research Center, UT Health San Antonio, San Antonio, TX, 2CareDx, Inc., Brisbane, CA, 3Long School of Medicine, UT Health San Antonio, San Antonio, TX

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a dynamic plasma biomarker for allograft rejection with limited data in pediatric renal transplant recipients and few reports describing…
  • 2022 American Transplant Congress

    Pediatric Acute Liver Failure: Patient Factors Associated with Higher Mortality

    J. Ascher Bartlett1, C. Weaver1, S. Barhouma2, L. Houshmand2, B. Rocque2, K. Etesami2, R. Kohli1, J. Emamaullee2

    1Children's Hospital Los Angeles, Los Angeles, CA, 2University of Southern California, Los Angeles, CA

    *Purpose: Pediatric acute liver failure (PALF) is characterized by sudden onset deteriorating liver function, progressive coagulopathy, and hepatic encephalopathy in previously healthy children. The clinical…
  • 2022 American Transplant Congress

    Utility of Urinary CTGF as a Biomarker of Progressive Allograft Dysfunction in Pediatric Renal Transplant Recipients

    L. Sheward1, J. Wedel1, N. Rodig1, A. Kho1, T. Blydt-Hansen2, R. B. Mannon3, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2BC Children's Hospital, Vancouver, BC, Canada, 3University of Nebraska Medical Center, Omaha, NE

    *Purpose: Previous reports from a number of studies indicate that renal allograft recipients who have inflammatory infiltrates within areas of interstitial fibrosis with tubular atrophy…
  • 2022 American Transplant Congress

    Utility of Four-Point Mycophenolate Mofetil Testing in a Pediatric Kidney Transplant Population

    S. Sadiq, P. Brakeman, J. Brennan, E. Black

    Pediatric Nephrology, UCSF, San Francisco, CA

    *Purpose: While there is randomized, multicenter data in adults that area under the time concentration curve (AUC) measurements for Mycophenolate Mofetil (MMF) can direct dosing…
  • 2022 American Transplant Congress

    Abnormal B Cell Profile Associated with Inadequate Antibody Response to MRNA SARS-COV-2 Vaccine Can Be Overcome with a Third Vaccine Dose in Adolescent Kidney Transplant Recipients

    C. Crane, E. Phebus, L. Loop, C. Anterasian, B. Geng, E. Ingulli

    Pediatrics, UCSD Rady Children's, San Diego, CA

    *Purpose: mRNA SARS-CoV-2 vaccines are highly efficacious in the general population but have shown a diminished response in immunosuppressed adolescent kidney allograft recipients. We investigated…
  • 2022 American Transplant Congress

    Impact of Arterial Reconstruction Technique on Hepatic Arterial Thrombosis in a Decade of Pediatric Liver Transplantation

    A. M. Delman1, Z. Farooqi1, E. Schepers1, A. Bondoc2, G. Tiao2, B. Mullapudi2

    1Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, 2Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    *Purpose: Hepatic artery thrombosis (HAT) is a morbid and potentially fatal complication following pediatric liver transplantation (PLT). Previous registry studies have identified preoperative characteristics associated…
  • 2022 American Transplant Congress

    A Cost Effectiveness Analysis of Adherence Promotion Strategies to Improve Rejection Rates in Adolescent Kidney Transplant Patients

    C. Varnell1, K. Rich1, A. Modi1, D. Hooper1, M. Eckman2

    1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati School of Medicine, Cincinnati, OH

    *Purpose: In adolescents with a kidney transplant, non-adherence increases the risk of graft loss. Adherence promotion interventions improve adherence and rejection rates, but perceived cost…
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